The end of ’Pump Fiction’


Förster resonance energy transfer (FRET) combines laser light and ultra-sensitive cameras that send signals into an individual molecule. This signal spreads to the other colour molecule on the pump, which begins to transmit light of another colour. The group focuses on the relationship between the different colours, which is registered in a specially built light microscope. These measurements provide information about the pump’s movements. (Photo: Mateusz Dyla)
Illustrated here is the timeline for the pump function, which is now revealed in high time resolution. The curve shows the relationship between the measured fluorescent colours emitted from dyes bound to the pump. At left, the pump is open towards the interior of the cell and has bound calcium ions and absorbed the ATP molecule – in other words, it is ‘charged’. The next step is the new, key result: in the red field, the pump is in the previously unknown closed state, where it has enclosed the ions to be sent out of the cell. The final stage illustrated shows that the pump has opened and released calcium ions into the surroundings. From here, it cannot return to the highlighted state. (Illustration: Daniel Terry/Dyla)

2017.11.09 | Research

The end of ‘Pump Fiction’

Our cells are capable of moving energy and material around to the places where they are required, and ensuring that the body works properly. But how do the cells do this in real time from the perspective of the individual molecule? A Danish research team has succeeded in revealing basic insights into this previously unknown world by carrying out…

2017.10.11 | Research

Molecular Velcro helps to assemble functional nuclear pore complexes

An international research team now explains how one of the largest molecular machineries - the nuclear pore complex – is being assembled using natively unfolded FG-repeats as molecular Velcro.

2017.10.12 | Research

Why do physicists blur their images before showing them to biologists?

How can cartoon images aid in understanding bacterial biological processes? How did Hollywood contribute to quantum physics? How do aesthetics, art, and design influence scientific visualization and vice versa? These are just some of the questions that a new book raises. Bjørn Panyella Pedersen, Ebbe Sloth Andersen and Ditte Høyer Engholm from…

2017.10.02 | Research

Llama-derived nanobodies as a new tool in solving crystal structure

Aarhus University scientists have developed miniature antibodies (nanobodies) that can be labelled on certain amino acids. This provides a direct route for solving new X-ray crystal structures of protein complexes important for gaining mechanistic understanding of cellular processes, which is important in the development of drugs.


Mon 20 Nov
09:15-10:00 | Dept. of Mathematics Aud G (1532-116)
MBG Focus Talk: Peter Refsing Andersen: Hacking gene expression: active heterochromatin in genetic arms races
Mon 20 Nov
13:00-15:00 | Sal O1, Undervisningshuset, Ultuna, Uppsala, Sweden
PhD defence: Berihu Gebremedhin Welderufael: Breeding for Recoverability – a Novel Approach to Improve Genetics of Udder Health in Dairy Cows
PhD defence, Monday 20 November 2017, Berihu Gebremedhin Welderufael.
Tue 21 Nov
13:00-14:30 | iNANO Auditorium
ERC Workshop at Science and Technology: Professor Carlos M. Duarte
This workshop gives insight and insider knowledge of ERC grant applications and the system behind. You also have the opportunity of an exclusive 1:1 session with professor Duarte regarding your ERC application.
Thu 23 Nov
10:15-11:00 | Lecture room of building 1110 (1110-223)
Infection and Immunity seminar: Mireia Pelegrin: Vaccine-like effect of antiviral monoclonal antibodies: converting immunotherapies from passive to active