DKK 30 million for high-tech electron microscopes for research in molecular cell biology



News

Professor Gregers Rom Andersen (left), Cryo-EM Facility Manager Thomas Boesen and Professor Poul Nissen in front of the Titan-Krios flagship microscope at Aarhus University (photo: Lisbeth Heilesen).

2018.11.08 | Grant

DKK 30 million for high-tech electron microscopes for research in molecular cell biology

The Minister for Higher Education and Science has approved funding for three new research infrastructures, of which DKK 30.76 million goes to EMBION – a research infrastructure for cryo-electron microscopy (cryo-EM) on biological materials.

Each individual domain antibody neutralizes a subset of influenza virus subtypes. However, when the domains are fused in to a multi-domain antibody the protein is able to neutralize a broad number of influenza virus subtypes. Figure: Nick Stub Laursen.
A llama was immunized with an influenza vaccine and an HA protein. Domain antibodies that neutralizes influenza virus were isolated and combined into a multi-domain antibody (MdAb). The MdAb gene was inserted into an adeno-associated virus (AAV) that was administered to mice for local expression of the MdAb, which protected the mice from subsequent infection with influenza virus. Atomic structures of influenza virus HA in complex with different domain antibodies. The trimeric HA molecule is shown in gray and the domain antibodies colored in blue, magenta, green and red. Figure: Nick Stub Laursen.

2018.11.02 | Research

Researches develop new protein for prevention of influenza virus infection

An international research team has developed a new protein drug which has the potential to be used for protection against all types of influenza infection. By delivering the drug as a DNA vector it may also function as a universal influenza vaccine.

Researchers are using New Breeding Techniques to improve crop yield and quality. The knowledge they create will be put to practical use in collaboration with the industry. Photo: Colourbox

2018.11.11 | Grant

Modern breeding technology can increase Denmark’s share of the market

Methods that are being developed in a new research project can strengthen Denmark’s competitive edge on the international market for crop seeds.

Structural representation of the crystal structure of the protein kinase RSK2 (grey surface) in complex with the drug dimethyl fumarate (yellow spheres). The light blue spheres represent water molecules bound to the protein structure that are also revealed from the crystal structure. The structure was determined at 1.9 Å resolution and the atomic coordinates are available in the protein data bank with access code 5O1S: www.rcsb.org/structure/5O1S
Model of DMF inhibition. Schematic figure of the activation loop transition between inactive and activated state of the C-terminal kinase domain (consisting of the ATP binding domain and the helix bundle domain). DMF targets an allosteric site and blocks kinase activation, and vice versa. Figure: Jacob Lauwring Andersen

2018.10.31 | Research

New insight into the mechanism of the drug against sclerosis and psoriasis

A multidisciplinary research team at Aarhus University has provided fundamental new insight into the mechanism of the medical drug dimethyl fumarate, which is the active component of important treatments for multiple sclerosis and psoriasis. The results contribute to the development of new strategies for drug discovery.

Events

Thu 22 Nov
13:15-15:15 | Building 1593, room 012, the Lecture Theatre, iNANO House
PhD defence: Veronica Liv Andersen: Tailor-made medicine from self-assembled biomolecules
Fri 23 Nov
14:00-15:00 | The lecture hall in the AIAS building: Building 1632, room 201
Information meeting with the Lundbeck Foundation
Anyone interested can come and hear more about the foundation’s strategy, new action plan and the associated new programmes.
Tue 27 Nov
13:00-15:00 | Meeting room 2, AU Conference Center, Frederik Nielsens Vej 4
Master's thesis defence: Kasper Sjödin Kristensen: Differential Lotus japonicus responses to compatible and semicompatible rhizobia
Supervisor: Stig Uggerhøj Andersen

PhD defences

Veronica Liv Andersen
Schematic representation of the proposed multifunctional nanostructure. The system consists of four modules carrying either multiple identical or different functional molecules, for instance a polymer for prolonging the circulation time in the blood stream, a targeting ligand for binding to specific disease-related receptors, an imaging agent for diagnostics and a bioactive drug.

2018.11.22 | PhD defense

Veronica Liv Andersen: Tailor-made medicine from self-assembled biomolecules

PhD defence, Thursday, 22 November 2018. Veronica Liv Andersen.

Rasmus Peter Thomsen
Examples of two DNA nanostructures used to engineer lipid bilayers and proteins, respectively.

2018.11.14 | PhD defense

Rasmus Peter Thomsen: Use of DNA nanotechnology to control molecular systems

PhD defense, Wednesday, 14 November 2018. Rasmus Peter Thomsen.