Danish researchers and Israeli biopharmaceutical company collaborate to develop anti-cancer drugs


News

The RedHill team assembled in Denmark. From left to right: Terry F. Plasse (MD, Medical Director, ReHill Biopharma), Danielle T. Abramson (Ph.D., Director, Intellectual Property and Research, RedHill Biopharma), Mark L. Levitt, (MD, Ph.D., Medical Director, Oncology, RedHill Biopharma), Emil Oldenburg (M.Sc., Scientific Assistant, Aarhus University), Christine R. Schar (Ph.D., Postdoctoral Fellow, Aarhus University) and Jan K. Jensen (Ph.D., Project Manager, Aarhus University).

2017.03.23 | Grant

Danish researchers and Israeli biopharmaceutical company collaborate to develop anti-cancer drugs

The Israeli Biopharmaceutical company RedHill Biopharma Ltd. (NASDAQ: RDHL) (Tel-Aviv Stock Exchange: RDHL) has extended its collaboration with researchers at Aarhus University in order to develop a potentially promising drug candidate for cancer treatment. The drug candidate is based on a protease inhibitor molecule - an area the Danish…

Model for monitoring and repairing damaged DNA (left figure). The crystal structure of the DNA control protein Rad26 that is responsible for bringing the Rad3 kinase to damaged DNA and starting repair signalling (right figure).

2017.03.20 | Research

Structural knowledge of the DNA repair complex

New Danish research provides mechanistic insight into how DNA is monitored and repaired if damage occurs. The results may eventually help to improve the treatment of certain types of cancer, as the DNA repair complex provides a mechanism for cancer cells to resist chemotherapy.

Model for RNA fate decisions: Early during its production by PolII, the CBC-bound cap of the emerging RNA is contacted by ‘productive’ (PHAX) and ‘destructive’ (ZC3H18) factors. These proteins form mutually exclusive complexes with the CBC until a ‘decision point’ (e.g. a terminator) is encountered by PolII, after which RNA fate is determined by stable interaction with either PHAX or ZC3H18.

2017.03.15 | Research

Sorting RNA for production or decay

Our genomes are promiscuously transcribed into RNA. How cells manage to sort this massive genomic output into functional and non-functional material has remained enigmatic. New research describes protein interactions involved in such RNA fate determination.

Adult zebrafish in the zebrafish facility at the Department of Molecular Biology and Genetics, Aarhus University, Denmark. Zebrafish in the wild are found in northeastern India, Bangladesh and Nepal in standing and slow flowing water in ditches, rice fields and ponds. The Latin name Danio reportedly comes from the word Dhani, which is Bengali for "from the rice fields." Photo: Lisbeth Heilesen.
The zebrafish facility at the Department of Molecular Biology and Genetics, Aarhus University, Denmark. Zebrafish take up less space on the shelves than mice. Photo: Kasper Kjær-Sørensen. Click photos for enlargement.
Zebrafish embryos are transparent. Here is a 24-hour old embryo as it appears in an ordinary light microscope. In addition to external structures such as yolk sac, head and eye, you can also see the brain, the inner ear and the V-shaped somites, which are the precursors of the V-shaped skeletal muscle. Photo: Kasper Kjær-Sørensen.
A 72-hour old transgenic embryo with green fluorescent protein (GFP) in the endothelial cells lining blood and lymphatic vessels. All vessels are clearly highlighted in the living body. Note that due to the high density of vessels surrounding the gills, the underside of the head appears overexposed in the image. Photo: Kasper Kjær-Sørensen.
Microinjection in newly fertilized embryos. The depicted embryos are about 30 minutes old. The first cell being formed can be seen at the bottom of the embryo near the top of the image. Photo: Kasper Kjær-Sørensen.

2017.03.03 | Research

The zebrafish is an important animal model

Humans and zebrafish have more in common than you would think. Therefore, zebrafish are used more and more, for example, to study the function of genes, to create animal models for human diseases and to develop new human drugs.

Events

Mon 27 Mar
10:15-11:00 | Aud I (1514-213), Institut for Kemi
Seminar: Helen E. Blackwell: Synthetic ligands for the interception of bacterial communication: New languages, new outcomes
Tue 28 Mar
12:15-14:00 | Science Park, Conference room, 3130-303
Qualifying exam: Investigation of membrane protein interactions by HDX-MS and Cryo-EM
Lars Sørensen
Thu 30 Mar
13:00-15:00 | Universitetshospital Skejby: AUH lokale 33, indgang D3
MSc exam ("specialeforsvar"): Mitochondrial Dysfunction in Chronic Fatigue Syndrome
Ulla Heltborg Kristensen
Thu 30 Mar
13:15-15:15 | 1590-213, iNano House, Gustav Wieds Vej 14
Qualifying exam: Molecular basis of parkinson's disease: The fate of cytotoxic oligomers under cell-like conditions
Anne Louise Hemdrup

PhD defences

Jens Kvist Madsen

2017.02.24 | Talent development

Jens Kvist Madsen: Protein-surfactant interactions in industrial applications

PhD defence, Friday, 24 February 2017. Jens Kvist Madsen.

Hans Christian Høiberg

2017.02.21 | Talent development

Hans Christian Høiberg: Nucleic acids nanodrugs - are we there yet?

PhD defence, Tuesday, 21 February 2017, Hans Christian Høiberg

Career day for students at MBG

The Department of Molecular Biology and Genetics invites all students at the department to a career day on

Friday 5 May 2017 at 14:00-ca. 16:30

at the Department of Mathematics, 1533-103, Aud. E

The speakers are all former Master students from the department representing different career paths. The event will include descriptions of the path their jobs, examples of everyday job situations and tasks, and how they use their education in their respective jobs.

More information - and registration (in Danish)

UK

Project day for Bachelor and Master student

The Department of Molecular Biology and Genetics holds a "Project Day" where researchers from the department will present projects for Bachelor and Master students on:

  • Wednesday 24 May 2017 at 14-16

in the old canteen at pavillion by the Science Park, Gustav Wieds Vej 10 (building 3140).

Seminar series at MBG