During his PhD studies, Hans Christian Høiberg has sought to exploit the predictable and programmable folding of nucleic acids to advance nucleic acid nanotechnology towards therapeutic application. Multiple avenues towards this goal have been explored; one, using a complex DNA origami structures to compare binding energies of biological binders. Two, applying a 3D RNA origami structure to selectively knock down a target reporter gene in cancer cells. And, three, using an RNA modifying enzyme to add a chemical handle to in vitro transcribed RNA allowing for subsequent chemical modification.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Tuesday, 21 February 2017 at 13.15
Place: Building 1593, room 012, the Lecture Theatre, iNANO House, Gustav Wieds Vej 14, Aarhus University, 8000 Aarhus C.
Title of dissertation: Towards Nucleic Acid Nanoparticles for Targeted Drug Delivery
Contact Info: Hans Christian Høiberg, e-mail: hchoeiberg@inano.dk, tel.: +45 2224 4133
Members of the assessment committee:
PhD, DSc, Professor Janusz Bujnicki, Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland
Professor MSO Henrik Nielsen, Cellular and Molecular Medicine, University of Copenhagen
Professor Jan Skov Pedersen (chair), iNANO and Department of Chemistry, Aarhus University
Main supervisor:
Professor Jørgen Kjems, iNANO and Department of Molecular Biology and Genetics, Aarhus University
Language: The PhD dissertation will be defended in English

The defense is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.