All cells are in need of a constant supply of phosphate to do vital processes such as DNA synthesis and glucose metabolism. The phosphate transporters PiT1 and PiT2 have been found to be important not only as suppliers of phosphate to the cell but also as regulators of phosphate independent processes.

Through her studies, Iben Boutrup Kongsfelt has studied the effect of overexpression of PiT1 and PiT2 on cell proliferation, metabolism, bone cell differentiation, and ectopic calcification. These results contribute with new insight into both phosphate dependent and phoshpate independent functions of the phosphate transporters PiT1 and PiT2 in very different processes in different cell types.

The PhD degree was completed at the Institute of Molecular Biology and Genetics, Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Wednesday 31 August 2016 at 13.00
Place: Building 1253, room 211, Auditorium 2, (Merete Barker Auditoriet , Søauditorierne), Aarhus University, Bartholins Allé 3, 8000 Aarhus C
Title of dissertation: Insight into new roles of the type III phosphate transporters as regulators of cell proliferation, energy metabolism, and osteoblastic differentiation
Contact information: Iben Boutrup Kongsfelt, e-mail: ibenbk@mbg.au.dk, tel.: +45 22564909
Members of the assessment committee:
Group leader, PhD Vicky MacRae, The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Scotland UK
Associate Professor Marie Kveiborg, Section of Molecular Pathology, BRIC, University of Copenhagen
Professor Claus Oxvig (chair), Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Associate Professor Lene Pedersen, Department of Molecular Biology and Genetics - Molecular Cell and Developmental Biology, Aarhus University
Language: The PhD dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.