The human genome produces enormous amounts of RNA molecules and many RNA species are not functionally characterized. During his studies, Jan Herudek researched how these RNAs behave upon inactivation of the RNA degradation machinery. By applying newly developed method for genome editing, Jan manipulated genes encoding proteins involved in RNA metabolism. This manipulation leads to a very fast inactivation of the RNA degradation machinery and thus to new findings how RNA molecules function in human cells.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Tuesday 25 October 2016 at 13.15
Place: Building 1532, room 116, Auditorium G1, Department of Mathematics, Aarhus University, Ny Munkegade 118, 8000 Aarhus C
Title of dissertation: Characterizing the transcriptome upon depletion of RNA processing factors
Contact information: Jan Herudek, e-mail: herudek@mbg.au.dk
Members of the assessment committee:
Directeur de recherche CNRS (DR2) Antonin Morillon, Unit of Dynamics of genetic Information, Institut Curie, Paris, France
Professor Anders Henrik Lund, Lund Group, Biotech Research and Innovation Centre (BRIC), Copenhagen University, Denmark
Associate professor Søren Borg, Department of Molecular Biology and Genetics, Aarhus University (chair)
Main supervisor:
Professor Torben Heick Jensen, Department of Molecular Biology and Genetics, Aarhus University
Language: The PhD dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.