During her studies, Kinga Winczura researched the proteins engaged in human RNA metabolism. All RNAs are subjected to various maturation events in order to become functional molecules. By applying extensive biochemical and functional approaches, Kinga showed how one of the proteins, called ZC3H18, contributes to the processes of RNA production and degradation.

The new research findings also contribute to the broader understanding of how gene expression is regulated.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Thursday 1 September 2016 at 14.00.
Place: Building 1253, room 317 (William Scharff – Lakeside Lecture Theatres), Aarhus University, Bartholins Allé 3, 8000 Aarhus C


Title of dissertation: Interaction profiling of human RNP complexes identifies ZC3H18 at the interface of RNA production and destruction decisions
Contact information: Kinga Winczura, e-mail: kinwin@mbg.au.dk
Members of the assessment committee:
Associate Professor Jan Christiansen, Department of Biology, Center for Computational and Applied Transcriptomics, University of Copenhagen, Copenhagen, Denmark
Dr. Markus Landthaler, Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
Associate Professor Anni Hangaard Andersen (chair), Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Professor Torben Heick Jensen, Department of Molecular Biology and Genetics, Aarhus University
Co-supervisor:
Dr. John LaCava, Laboratory of Cellular and Structural Biology, Rockefeller University, USA
Language: The PhD dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.