Nadia Sukusu Nielsen: Investigation of the Disease Mechanisms of TGFBI-linked Corneal Dystrophies

PhD defence, Wednesday 4 April 2018, Nadia Sukusu Nielsen.

2018.04.04 | Lisbeth Heilesen

Nadia Sukusu Nielsen

Transforming growth factor beta-induced (TGFBI)-linked corneal dystrophies is a group of inherited diseases characterized by protein aggregation in the cornea leading to invalidating loss of vision or blindness. The protein TGFBIp is the main constituent of the protein aggregates. Nadia Sukusu Nielsen studied the involvement of proteases in TGFBIp aggregation and found that the serine protease HtrA1 is implicated in the disease progression. In addition, she investigated the natural function of TGFBIp and determined its three-dimensional structure. These findings might contribute to future drug development.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Wednesday 4 April 2018 at 10:15
Place: 1593-012, iNANO auditorium, Aarhus University, 8000 Aarhus C.
Title of PhD thesis: Transforming growth factor β-induced protein - A study of structure, function, and proteolytic processing in relation to corneal dystrophies
Contact information: Nadia Sukusu Nielsen, e-mail:, tel.: +45 28382464
Members of the assessment committee:
Professor Goran Petrovski, Institute of Clinical Medicine, University of Oslo, Norway
Professor Michael Toft Overgaard, Department of Chemistry and Bioscience, Aalborg University
Professor Jørgen Kjems (chair), iNANO and Department of  Molecular Biology and Genetics, Aarhus University
Main supervisor:
Professor Jan J. Enghild, iNANO and Department of  Molecular Biology and Genetics, Aarhus University
Assistant Professor Ebbe Toftgaard Poulsen, Department of  Molecular Biology and Genetics, Aarhus University
Language: The PhD thesis will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST,
Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C. 

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