Cemre Manav: To Live or Not To Live: Bacterial Survival Mechanisms

PhD defence, Friday 5 October 2018. M. Cemre Manav.

2018.10.05 | Lisbeth Heilesen

Cemre Manav

During her PhD studies, M. Cemre Manav has worked on bacterial persistence and antibiotic resistance. Antibiotic-resistant bacteria is the main cause of antibiotic failure due to overuse and/or misuse of antibiotics. For instance, methicillin-resistant bacteria is the cause of post-operation hospital infections.

Each time the patient takes antibiotics, they trigger certain stress responses in the bacterial cells. During the course where the antibiotic is effective, the sensitive bacterial population dies. However, the resistant bit survives and sort of hides until the stressful conditions are switched back to normal. Once the antibiotic loses its activity, the bacterial cells revert from being resistant back to normal growing cells and keep existing in the host. In her PhD research, Cemre has sought information about how the bacteria can activate such stress responses in order to stay alive and how they can go back to normal growth again. She has used X-ray crystallography and electron microscopy techniques to study the enzymes responsible for triggering such protective mechanisms at a molecular level.

The PhD degree was completed at the Department of Molecular Biology and Genetics Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Friday 5 October 2018 at 13.15
Place: Building 1593, Room 012, the iNANO Auditorium, iNANO House, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C.
Title of PhD thesis: Structural and Functional Studies of Bacterial Stress Response Mechanisms
Contact information: M. Cemre Manav, e-mail: cemremnv@mbg.au.dk, tel.: +45 6143 7495
Members of the assessment committee:
Chargé de Cours définitif Abel Garcia-Pino, Institut de biologie et de médecine moléculaires (IBMM), Université Libre de Bruxelles, Belgium
Professor Michael Gajhede, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark
Associate Professor Charlotte Rohde Knudsen, Department of Molecular Biology and Genetics, Aarhus University (chair)
Main supervisor:
Associate Professor Ditlev Egeskov Brodersen, Department of Molecular Biology and Genetics, Aarhus University
Language: The PhD thesis will be defended in English

The defense is public.
The PhD thesis is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520 and 1521, 8000 Aarhus C.

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