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The research group behind the identification of new unique cornea proteins. Back row from left: Ebbe Toftgaard Poulsen, Thomas F. Dyrlund, Jan J. Enghild. Front road: Camilla Lund Nikolajsen, Ida B Thøgersen and Carsten Scavenius. Henrik Vorum also participated in the studies. (Photo: Lisbeth Heilesen).
Figure left: Number of overlapping proteins identified in the three layers of the human cornea. A total of 3250 unique proteins were identified, 2737 in the epithelial, 1679 in the stromal and 880 in the endothelial layer. Right: Number of overlapping proteins quantified in the three layers of the human cornea. A total of 771 proteins were quantified, 634 in the epithelial, 342 in the stromal and 140 in the endothelial layer.
Diseased cornea with protein deposits.

2012.06.29 | Public / media, Department of Molecular Biology and Genetics

Identification of new unique cornea proteins

With the identification and quantification of a large number of cornea proteins, a research group at Aarhus University has taken a big step closer to characterising the protein profile required to maintain corneal homeostasis (balance). This information may be used for exploring the basic molecular mechanisms involved in corneal health and…

Figure. Structural analysis of 12ADT=Asp binding to SERCA pump. (a) 12ADT=Asp bound to SERCA pump (blue) demonstrating predominant binding of TG pharmacophore (yellow space filling) to the transmembrane domain with extension of the Asp moiety (green) into the space between the ?-helices making up the transmembrane domain. (b) the ?-amine group of the Asp moiety forms a hydrogen bond with Gln 250 of the SERCA pump (residue shown in stick representation) and potential interaction with phospholipid. (c) the Asp moiety of 12ADT=Asp (yellow) occupies a similar site in the SERCA as the known SERCA pump inhibitor CPA (aquamarine). b,c Colour code: Transmembrane (TM) 1-2 purple, TM3-4 green, TM5-6 orange, TM7-10 wheat, P-domain blue, A-domain yellow, Asp-ADT yellow, phosphatidylethanolamine (PE) aquamarine, electron density 2Fo-Fc grey (contour level 1 sigma), hydrogen bond grey, CPA aquamarine (figures: Ingrid Dach)

2012.06.28 | Public / media, Department of Molecular Biology and Genetics

New cancer drug shows great promise

Danish researchers have developed a new drug against prostate cancer in collaboration with researchers from Johns Hopkins University and the biotech company Genspera in the USA.

Manfred Schmid (left) and Torben Heick Jensen have revealed a function in gene expression regulation for a protein connected with the proper function of neurons. Further analysis of this unexpected function of protein binding may ultimately lead to the understanding of how neurological defects occur with abnormalities in this protein. Click figure for enlargement  (Photo: Lisbeth Heilesen)
Figure: Poly(A) tails (a stretch of adenosine ‘A’ residues) are added at the end of the RNA (black line) by an enzyme called Pap1 (dark green oval symbol) and the tails are bound by the proteins Pab1 (light-green diamond symbol) and/or Nab2 (red circle symbol). In normal ‘wild-type’ cells (wt, left panel), the poly(A) tail is bound by Pab1, whereas Nab2-binding is prevented by Rrp6 (orange PacMan symbol). In addition, Rrp6 counteracts the action of the TRAMP complex (dark blue oval), which can extend tails beyond normal length. Both functions are revealed in mutant yeast cells lacking Rrp6 (rrp6?, right panel), where Nab2 does bind poly(A) tails and TRAMP extends poly(A) tails beyond their normal length (hyperadenylation). Click figure for enlargement (Figure: Manfred Schmid).

2012.06.08 | Public / media, Department of Molecular Biology and Genetics

Surprising new mechanism for gene expression regulation

New research results reveal a function in gene expression regulation for a protein connected with the proper function of neurons. Further analysis of this unexpected function of protein binding may ultimately lead to the understanding of how neurological defects may result from abnormalities in this protein.

Hans Henrik Gad

2012.06.01 | People, Department of Molecular Biology and Genetics

Hans Henrik Gad

er ansat som postdoc pr. 1. juni 2012-31. maj 2013. Hans Henrik fik tildelt et ph.d.-stipendium for perioden 1. marts 2009-30. marts 2012 fra Styrelsen for Forskning og Innovation. Han har gennem hele perioden været udstationeret ved Université Paris VII - Paris Diderot (med arbejdsplads på Institut Pasteur), hvorfra han i marts 2012 opnåede…

Jayashree Sahana

2012.06.01 | People, Department of Molecular Biology and Genetics

Jayashree Sahana

Jayashree Sahana er pr. 1. juni 2012 ansat som laboratorieoverassistent 20 t/uge i en op­slået stilling ved instituttet i Suresh Rattans forskningsgruppe. Ansættelsen finan­si­e­res af MBG.