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Danish and Canadian researchers have uncovered important molecular details about the regulation of the cell biosynthesis-machinery during cellular stress. This knowledge has implications for anti-cancer treatment, since the implicated factors are key regulators of cell growth and proliferation.
Figure 2: LARP1 represses TOP mRNA translation downstream of mTOR. The left panel illustrates how TOP mRNA remains translated during normal growth conditions, where both LARP1 and eIF4E-BP1 (4E-BP1) are phosphorylated (P). This allows eIF4F (includes eIF4E, eIF4G and eIF4A) to interact with the cap-structure (m7Gppp) on the mRNA and effectively recruit the ribosome (40S/60S). The right panel shows stress conditions where LARP1 and eIF4E-BP1 are active (non-phosphorylated). These proteins will interact with eIF4E and the TOP sequence, respectively, which in turn occludes eIF4G association with the complex and translation becomes inefficient. The study also demonstrates that LARP1 stabilizes TOP mRNAs. Figure: Bruno Fonseca and Christian Damgaard

2015.05.22 | Research

New insights into fundamental stress-regulated cellular processes

Danish and Canadian researchers have uncovered important molecular details about the regulation of the cell biosynthesis-machinery during cellular stress. This knowledge has implications for anti-cancer treatment, since the implicated factors are key regulators of cell growth and proliferation.

Sadegh Nabavi

2015.05.22 | People

New Group Leader appointed at DANDRITE

Sadegh Nabavi has been appointed as the fifth Group Leader at MBG-DANDRITE, thus completing the new group leader recruitments at DANDRITE. Sadegh Nabavi will start his research activities on memory formation and consolidation at the synaptic and circuit levels

The researchers intend to study whether there is evidence that certain genes can affect healthspan, and if so, which genes. Figure: Suresh Rattan.

2015.05.19 | Grant

The key to healthy ageing

In order to increase the quality of life, a group of researchers from the Laboratory of Cellular Ageing at Aarhus University, and their foreign collaborators intend to find the factors that influence health, ageing and longevity. The new project is supported by the EU with a grant amounting to Euro 7 million.

A newly developed method that combines phase extraction with an enzymatic reaction may eventually be used for an improved and faster screening analysis of isatin as a potential indicator of stress and neurological disorders. Figure: J. Preben Morth and Lisbeth Heilesen.

2015.05.11 | Research

Method for determining possible stress marker in blood samples

A research collaboration between the universities of Oslo and Aarhus has resulted in the development of a new method with diagnostic potential. The new method that combines phase extraction with an enzymatic reaction may eventually be used for an improved and faster screening analysis of isatin as a potential indicator of stress and neurological…

To the left, an illustration of the principle behind Spiegelmers. Normal aptamers are formed from D-nucleotides also used for RNA and DNA, whereas the Spiegelmers are constructed from L-nucleotides. The two molecules are therefore perfect mirror-images of each other. To the right is shown the three-dimensional structure of the Spiegelmer from the German company NOXXON Pharma AG bound to the inflammatory protein C5a determined by the scientists at Aarhus University through X-ray crystallography. Figure: Laure Yatime.

2015.05.05 | Research, Knowledge exchange

Aarhus scientists look through the mirror to reveal the secrets of a new drug

Research results from Aarhus University can help develop anti-inflammatory drugs.