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2016.06.22 | Grant

Large grants to researchers from MBG

The Danish Council for Independent Research ("Det Frie Forskningsråd") ("DFF") has given six grants amounting to DKK 18 million to researchers at the Department of Molecular Biology and Genetics.

The figure depicts one of the X-ray crystal structures solved by the research team. Shown is the serine protease urokinase-type plasminogen activator (green) in complex with a Camelid antibody fragment (orange). The Camelid antibody fragment display an unusual inhibitory mechanism by binding to the active site region (highlighted in blue) of the serine protease where it mimics the binding of substrate. Figure: Tobias Kromann-Hansen

2016.06.15 | Research

The use of Camelid antibodies for structural biology

The use of Camelid antibodies has important implications for future development of reagents for diagnosis and therapeutics in diseases involving a group of enzymes called serine proteases.

Incorrectly folded proteins can cause a variety of diseases. Danish researchers have found a solution for preventing this misfolding. Figure: Jan K. Jensen.

2016.06.09 | Research

A new way for prevention of pathogenic protein misfolding

Incorrectly folded proteins can cause a variety of diseases. Danish researchers have found a solution for preventing this misfolding.

The atomic structure of C5 (blue) bound to the C5-binding part of eculizumab (yellow) shows how eculizumab blocks the cleavage of C5 in blood circulation. This rescues the red blood cells (red disks) from disruption. In real life the proteins are 500 times smaller than the red blood cells. Figure: Janus Asbjørn Schatz-Jakobsen.

2016.06.03 | Research, Knowledge exchange

The therapeutic antibody eculizumab caught in action

In collaboration with Alexion Pharmaceuticals, Inc., scientists from Aarhus University have used X-rays to understand how the therapeutic antibody eculizumab prevents our immune system from destroying red blood cells and damaging kidney tissue.