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The figure shows the structure of C1 investigated by two different techniques. To the left is shown data recorded by the scientists with X- (black curve) at the PETRA III synchrotron in Hamborg. The grey curve shows how a curve calculated from the model in the middle panel fits to the eksperimental data. To the right  is shown so-called class averages of images recorded with electron microskopy. In row two to the right is clearly seen 10 protrusions, which is strictly nono-compatible with the the old model for activation of complement. For this reason the EM-data was pivotal for the results.

2017.01.20 | Research

A new model for activation of the immune system

By studying a large protein (the C1 protein) with X-rays and electron microscopy, researchers from Aarhus University in Denmark have established a new model for how an important part of the innate immune system is activated. The activation of the C1 protein is a fundamental mechanism in immunology, and therefore the new research results also have…

An example of a structure of PRPP synthase. Figure: Kasper Røjkjær Andersen.
The team's research adorns the cover of Microbiology and Molecular Biology Reviews. Cover: Kasper Røjkjær Andersen.

2017.01.02 | Research

Survey of knowledge on how to combat microorganisms

A comprehensive knowledge of the synthesis of organisms and the utilisation of the compound PRPP may be useful in efforts to develop methods for combating microorganisms that can infect humans and other mammals. An international research team has now made a complete list of results in the field.