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Suresh Rattan

2017.11.30 | People

Suresh Rattan conferred an honorary professorship in Poland

Suresh Rattan Ph.D., Dr.scient. has been awarded an honorary professorship at the University of Rzeszów in Poland.

Adult fish in the zebrafish facility at the Department of Molecular Biology and Genetics, AU. Photo: Lisbeth Heilesen.
Comparison of ECG traces from humans and from two-day old zebrafish. The zebrafish ECG shows the same characteristics as the human ECG, making it possible to measure the QT interval. The blue trace represents a normal zebrafish ECG, the red trace displays short QT. Figure: Vladimir Matchkov and Christian Aalkjær.

2017.11.26 | Research

Zebrafish used to identify disease mechanism for heart disease

In a large collaborative study between the Department of Clinical Medicine, the Department of Biomedicine, and the Department of Molecular Biology and Genetics, among others, the researchers have succeeded in identifying and characterising the consequences of a newly discovered mutation associated with cardiac arrhythmia.

Förster resonance energy transfer (FRET) combines laser light and ultra-sensitive cameras that send signals into an individual molecule. This signal spreads to the other colour molecule on the pump, which begins to transmit light of another colour. The group focuses on the relationship between the different colours, which is registered in a specially built light microscope. These measurements provide information about the pump’s movements. (Photo: Mateusz Dyla)
Illustrated here is the timeline for the pump function, which is now revealed in high time resolution. The curve shows the relationship between the measured fluorescent colours emitted from dyes bound to the pump. At left, the pump is open towards the interior of the cell and has bound calcium ions and absorbed the ATP molecule – in other words, it is ‘charged’. The next step is the new, key result: in the red field, the pump is in the previously unknown closed state, where it has enclosed the ions to be sent out of the cell. The final stage illustrated shows that the pump has opened and released calcium ions into the surroundings. From here, it cannot return to the highlighted state. (Illustration: Daniel Terry/Dyla)

2017.11.09 | Research

The end of ‘Pump Fiction’

Our cells are capable of moving energy and material around to the places where they are required, and ensuring that the body works properly. But how do the cells do this in real time from the perspective of the individual molecule? A Danish research team has succeeded in revealing basic insights into this previously unknown world by carrying out…