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Jaslyn Wong. Photo: Novo Nordisk Foundation
Recipients of a grant for studies abroad. Photo: Novo Nordisk Foundation
Several of the members from the lab participated in the ceremony in Copenhagen. Photo: Terry Mun.

2018.05.24 | Research

Talented researcher awarded large grant from the Novo Nordisk Foundation

At a ceremony in Copenhagen, Jaslyn Wong from the Department of Molecular Biology and Genetics was awarded a 4-year postdoc grant from the Novo Nordisk Foundation valued DKK 3,44 million for three years’ study in Cambridge and one year in Aarhus.

Figure. A functional competition between RNA export factor AlyREF and the RNA exosome adaptor protein ZFC3H1 determines the fate of polyadenylated RNA. Shortly after RNA transcription starts, the nascent RNA is bound by the cap-binding proteins, CBP20 and CBP80. ARS2 directly interacts with CBP20/CBP80 to bridge interactions with several different complexes that determine RNA fate. (Left panel of the figure). Polyadenylated RNAs, like most mRNAs, are exported from the nucleus to the cytoplasm in a process involving the export factor AlyREF, which interacts with CBP20/CBP80 to recruit the export machinery. (Right panel of the figure). ZFC3H1 acts as a central factor in retention and degradation of polyadenylated RNA. This prevents unwanted RNAs from entering the cytoplasm where they could potentially cause a global translation collapse. Figure: Toomas Silla.

2018.05.16 | Research

New nuclear RNA retention activity discovered

Gene expression involves mRNA transport from its place of synthesis to the cytoplasm where protein translation occurs. However, many non-coding RNA species do not follow this flow and new data now demonstrate how cells prevent the unwanted export of RNA and instead ensure nuclear degradation.