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Professor Torben Heick Jensen receives DKK 60 million from the Novo Nordisk Foundation to establish the research center 'Exo-Adapt', which will determine how our cells sort genetic information. Photo: Lisbeth Heilesen.

2019.01.08 | Grant

60 million Danish kroner for basic biomedical research

Professor Torben Heick Jensen, Department of Molecular Biology and Genetics, Aarhus University, receives DKK 60 million (Euro 8 million) from the Novo Nordisk Foundation's Challenge Programme to establish the research center 'Exo-Adapt', which will determine how our cells sort genetic information.

Gregers Rom Andersen (left) and Poul Nissen participate in a new three-year EU project, which has received a grant from the EU of EUR 3.6 million. Photo: Lisbeth Heilesen
The HALOS collaboration includes eight academic research institutes in Sweden, Denmark, Norway and Germany, MAX IV and ESS in Sweden, DESY and the European XFEL in Germany, the Medicon Valley Alliance (MVA), industry in MedTech, BioTech and Pharma, Region Skåne, the Capital Region of Denmark and the City of Hamburg. Figure: Lund University

2019.01.02 | Grant

Aarhus University participates in a new Oresund-Kattegat-Skagerak EU Life Science Network

Gregers Rom Andersen and Poul Nissen from the Department of Molecular Biology and Genetics, Aarhus University, participate in a new three-year EU project for the Oresund-Kattegat-Skagerak (OKS) area, which has received a grant from the EU of EUR 3.6 million.

The cow's genetics and changes in her rumen flora can affect how much methane she emits. Photo: Janne Hansen

2018.12.12 | Research

Methane from cow burps can be reduced by a two-front approach

Combing a cow’s own genetics with strategies that target changes in her rumen flora may be able to reduce methane emissions more effectively than by only selecting for low methane-emitting cows.

2018.12.06 | Grant

Six researchers from MBG receive a grant from the Novo Nordisk Foundation

The Novo Nordisk Foundation has awarded a total of 51 grants for project support in Life Sciences and Basic Biomedicine. Of this, six MBG researchers have been granted a grant.

The Bioinnovation Institute has  a total of 12,000 m2 at its disposal and is housed in Copenhagen. Photo: The Novo Nordisk Foundation.
Poul Nissen has been appointed as an expert to assist the Novo Nordisk Foundation to find the best researchers in the life science area for their new incubation programmes at the Bioinnovation Institute. Photo: Lisbeth Heilesen

2018.11.29 | People

New incubation programmes from the Novo Nordisk Foundation

The Novo Nordisk Foundation's new Bioinnovation Institute (BII) has appointed a panel from universities, venture funds and life science companies to help assess applications for their new incubation programmes.

With a new project, researchers hope to be able to develop "artificial tasting machines". Photo: Colourbox

2018.11.20 | Grant

DNA molecules will be used to mimic human sense of taste

Human sense of taste is complex and difficult to imitate. An interdisciplinary project is now aiming at developing extremely fast "artificial tasting machines" that use DNA molecules as billions of small "sensors" to imitate human sense of taste with unprecedented accuracy.

Professor Gregers Rom Andersen (left), Cryo-EM Facility Manager Thomas Boesen and Professor Poul Nissen in front of the Titan-Krios flagship microscope at Aarhus University (photo: Lisbeth Heilesen).

2018.11.08 | Grant

DKK 30 million for high-tech electron microscopes for research in molecular cell biology

The Minister for Higher Education and Science has approved funding for three new research infrastructures, of which DKK 30.76 million goes to EMBION – a research infrastructure for cryo-electron microscopy (cryo-EM) on biological materials.

Each individual domain antibody neutralizes a subset of influenza virus subtypes. However, when the domains are fused in to a multi-domain antibody the protein is able to neutralize a broad number of influenza virus subtypes. Figure: Nick Stub Laursen.
A llama was immunized with an influenza vaccine and an HA protein. Domain antibodies that neutralizes influenza virus were isolated and combined into a multi-domain antibody (MdAb). The MdAb gene was inserted into an adeno-associated virus (AAV) that was administered to mice for local expression of the MdAb, which protected the mice from subsequent infection with influenza virus. Atomic structures of influenza virus HA in complex with different domain antibodies. The trimeric HA molecule is shown in gray and the domain antibodies colored in blue, magenta, green and red. Figure: Nick Stub Laursen.

2018.11.02 | Research

Researches develop new protein for prevention of influenza virus infection

An international research team has developed a new protein drug which has the potential to be used for protection against all types of influenza infection. By delivering the drug as a DNA vector it may also function as a universal influenza vaccine.

Researchers are using New Breeding Techniques to improve crop yield and quality. The knowledge they create will be put to practical use in collaboration with the industry. Photo: Colourbox

2018.11.11 | Grant

Modern breeding technology can increase Denmark’s share of the market

Methods that are being developed in a new research project can strengthen Denmark’s competitive edge on the international market for crop seeds.

Structural representation of the crystal structure of the protein kinase RSK2 (grey surface) in complex with the drug dimethyl fumarate (yellow spheres). The light blue spheres represent water molecules bound to the protein structure that are also revealed from the crystal structure. The structure was determined at 1.9 Å resolution and the atomic coordinates are available in the protein data bank with access code 5O1S: www.rcsb.org/structure/5O1S
Model of DMF inhibition. Schematic figure of the activation loop transition between inactive and activated state of the C-terminal kinase domain (consisting of the ATP binding domain and the helix bundle domain). DMF targets an allosteric site and blocks kinase activation, and vice versa. Figure: Jacob Lauwring Andersen

2018.10.31 | Research

New insight into the mechanism of the drug against sclerosis and psoriasis

A multidisciplinary research team at Aarhus University has provided fundamental new insight into the mechanism of the medical drug dimethyl fumarate, which is the active component of important treatments for multiple sclerosis and psoriasis. The results contribute to the development of new strategies for drug discovery.

The concentrations of Nod factor are controlled by CHIT5 and this is important for establishing functional symbiosis (red nodules) versus defect symbiosis (white nodules). Figure: Kasper Røjkjær Andersen, Simon Kelly and Simona Radutoiu.

2018.10.12 | Research

Goldilocks principle in biology – fine-tuning the ‘just right’ signal load

In the fairy tale "Goldilock and the Three Bears", the girl Goldilock goes to the bears’ house where she finds three bowls of porridge, but only one has the “just right” temperature, and in the same way within biology, you can find the "just right" conditions - called the Goldilocks principle. This is precisely what an international research team…

Upper panel: Wild type roots form nodules whether or not they are transgenic (the latter are marked by green fluorescence). Lower panel: Downregulation of miR2111 in transgenic roots (marked by green fluorescence) leads to reduced symbiosis. Nitrogen-fixing nodules (red fluorescence) preferentially form on non-transgenic roots that have normal miR2111 activity. Figure: Katharina Markmann.

2018.09.25 | Research

How leaves talk to roots

New findings show that a micro RNA from the shoot keeps legume roots susceptible to symbiotic infection by downregulating a gene that would otherwise hinder root responses to symbiotic bacteria. These findings help us understand what it takes to make nitrogen-fixing symbiosis efficient, and what we need to do to exploit it agronomically.

2018.09.24 | Grant

30 million DKK to develop optimised crops

Together with researchers from the University of Copenhagen and plant breeding companies, Henrik Brinch-Pedersen from the Department of Molecular Biology and Genetics has received DKK 30 million from the Innovation Fund Denmark to develop crops with improved properties by the use of CRISPR.

Figure: Søren Lykke-Andersen.
<b>Figure 1 | The structure of the snoRNA dictates the production of the protein-coding host. </b> Schematic illustration of how two different snoRNA structures impact the expression of the host gene. Left: specific snoRNA structure obtained when snoRNA proteins bind to the snoRNA. This structure facilitates an alternative splicing of the RNA, inhibiting the production of protein. Right: Alternative snoRNA structure formed by the naked snoRNA, which leads to the production of a protein-coding mRNA, ultimately producing protein. Figure: Søren Lykke-Andersen.
<b>Figure 2| Evolution of snoRNA genes and function.</b> Left: Independent snoRNA gene unit, which is the predominant snoRNA gene organization in e.g. yeast. Middle: snoRNA hosted in the intron (red line) of a protein-coding gene. The green boxes indicate coding regions called exons. This is the predominant snoRNA gene organization in e.g. humans. Right: In the described study it was demonstrated that a specific intron-hosted snoRNA controls the splicing of its host transcript. Figure: Søren Lykke-Andersen.

2018.09.19 | Research

Co-evolution between a "parasite gene" and its host

A Danish research team has delineated a complex symbiosis between a ‘parasitic’ noncoding RNA gene and its protein coding ‘host’ gene in human cells. The study reveals how co-evolution of the host gene and parasite gene has shaped a feedback mechanism in which the parasite gene plays a completely new and surprising part as regulator of the host…

Advanced fluorescence microscopy has shown that the structural change on the ribosome of the protein called EF-Tu is far smaller than previously assumed. Photo: Yale E. Goldman.
Decoding the genetic code on the ribosome. The figure shows how aa-tRNA (bend red line) is delivered by EF-Tu (green) onto the ribosome (light blue) in a step-by-step process that can be followed by advanced fluorescence microscopy. In step I, aa-tRNA is bound in complex with EF-Tu·GTP near the ribosomal A-site. In step II, the first test is performed to see whether codon and anticodon match, which can lead to the hydrolysis of GTP bound by EF-Tu. After a further proofreading of aa-tRNA anticodon in step III, the aa-tRNA is fully accommodated in the ribosomal A-site with the help of EF-Tu, which begins to change shape during this step. EF-Tu completes its structural change only after leaving the ribosome in Step IV. Figure: Chunlai Chen and Charlotte Rohde Knudsen.

2018.09.17 | Research

Advanced fluorescence microscopy reveals new aspects of protein pathways on the ribosome

The protein called translation elongation factor EF-Tu is a well-known player in the protein synthesis process. A new scientific article describes novel aspects of this well-described protein, which appears to play an even more important role in securing the accuracy of translation than previously assumed. The results may have an influence on the…

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