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The researchers have identified a new and unfamiliar role for a conserved enzyme complex for the maintenance of genomic stability by a protein-DNA barrier that blocks replication, from left Iben B. Bentsen and Lotte Bjergbæk (Photo: Lisbeth Heilesen).
(A) Suggested functions of the MRX complex upon replication fork stalling at a protein-DNA barrier. The MRX complex may hinder chicken foot formation (left) or protect a reversed fork from further processing (right). (B) Model for the cellular consequences to elevated levels of replication fork stalling in the rDNA (left panel), and for ectopically placed RFBs (right panel) in mre11? cells. Fob1 induction generates a higher level of active RFBs in the rDNA, which have detrimental effect on growth when the MRX complex is absent. Aberrant structures generated in the absence of the MRX complex are checkpoint-blind in the rDNA due to the presence of Sir2, whereas ectopically placed RFBs provoke a checkpoint signal in the absence of the MRX complex. Open bubbles represent active origins, whereas black dots represent inactive origins. Arrowheads represent Fob1-bound RFB sequences (figure: Iben Bentsen) Click photo and figure for enlargement

2013.02.04 | Research, Public / media

An enzyme complex maintains genome stability at replication roadblocks

During each cell cycle, the genome must undergo complete and faithful DNA replication to allow correct segregation of the duplicated chromosomes to the daughter cells. However, imperfections in the DNA template or physical roadblocks can threaten the fidelity of the replication machinery and thereby jeopardise genomic integrity. Studies on how…

Scientists at Aarhus University have developed a method which they have used to produce a unique type of barley containing only the healthy form of carbohydrate. Photo: Janne Hansen, AU

2013.02.04 | Public / media, Department of Molecular Biology and Genetics

Gene switch-off produces healthier carbohydrates

For the first time ever scientists have succeeded in producing a crop containing only healthy carbohydrates. Easily digestible starch, which is the lesser healthy version of carbohydrates, was avoided by switching off specific genes in barley.

Professor Gregers Rom Andersen (photo: Lisbeth Heilesen)

2013.01.24 | Public / media, Department of Molecular Biology and Genetics

New professor with focus on the immune system

Gregers Rom Andersen has been appointed professor of structural biology at the Department of Molecular Biology and Genetics at Aarhus University

The Spotted Landrace pig is one of the old farm animal breeds that is worth preserving. Photo: Colourbox

2013.01.21 | Public / media, Department of Molecular Biology and Genetics

The history of Danish historic animals

A new report describes the work on preserving the genetic resources of Danish livestock.

Maria Andreasen (photo: Lisbeth Heilesen)

2013.01.15 | Public / media, Department of Molecular Biology and Genetics

Young elite researcher prize awarded to Maria Andreasen

The Danish Council for Independent Research | Natural Sciences (FNU) has awarded Maria Andreasen a prestigious Sapere Aude Young Elite Researcher Prize for her research project entitled: “Caught in the act – Identifying primary nucleation events for fibrillating proteins.”

Eva Arnspang Christensen has been granted DKK 2.245 million from the Sapere Aude programme to learn advanced microscopy techniques at the National Institutes of Health, USA (photo: Lisbeth Heilesen)

2013.01.11 | Public / media, Department of Molecular Biology and Genetics

Young Elite Researcher Prize awarded to Eva Arnspang Christensen

The Danish Council for Independent Research | Natural Sciences (FNU) has awarded a prestigious Sapere Aude Young Elite Researcher Prize valued at DKK 2.245 million to Postdoctoral Fellow Eva Arnspang Christensen (36), Department of Molecular Biology and Genetics, for her research project ‘Aquaporin assembly and regulation: studied by…

A new booklet from the Danish Museum of Natural History is filled with lots of interesting information about poultry. Photo: Janne Hansen

2013.01.11 | Public / media, Department of Molecular Biology and Genetics

Booklet on the hen

A new booklet published by the Danish Museum of Natural History, written by senior scientist Poul Sørensen from Aarhus University, covers the subject of hens and chickens in an easily approachable way.

The researchers behind the study, from left: Jacob Fredsøe, Anni Hangaard Andersen and Jakob Madsen Pedersen (photo: Lisbeth Heilesen) Click photo and figures for enlargement.
Topoisomerases are required for transcription of chromatin regulated genes. Transcription levels of the individual genes are measured by qPCR in cells with (wild type) or without (top1?top2ts) topoisomerases. (figure: Jacob Fredsøe)
Topoisomerases are required for binding of transcription factor Pho4 to the promoter region of the chromatin regulated PHO5 gene and thereby for activation of this gene. The four nucleosomes in the PHO5 promoter (A) remain bound to the PHO5 promoter in the absence of topoisomerases (B). Under normal conditions the Pho4 transcription factor binds UAS1 after which chromatin remodelers are recruited to remove nucleosomes and allow further binding of transcription factors. In the absence of topoisomerases the Pho4 transcription factor still enters the nucleus (C), but is unable to bind the PHO5 promoter (D). (figure: Jacob Fredsøe)

2013.01.03 | Public / media, Department of Molecular Biology and Genetics

DNA topology important for gene activity

Maintenance of all life requires a strict control of gene activity for the cell to give an optimal response to internal as well as environmental changes. New results now demonstrate that DNA topology plays an important role.

The different joints of the lizard’s tail (Photo: Jan Enghild)
A) The lizard’s released tail stump observed from the side. This image shows the wedge-shaped structures. B) Zoom on one of these structures. C) The part of the tail stump that remains on the animal. The grooves visible just below the surface fit the wedge-shaped structures shown in A) (Figure: Kristian W. Sanggaard)

2012.12.21 | Public / media, Department of Molecular Biology and Genetics

How does a lizard lose its tail?

Researchers at Aarhus University have now found the answer to this question, attracting enormous international attention.

Christian Bendixen

2012.12.17 | Public / media, Department of Molecular Biology and Genetics

Coding for curdling: genetics and the good cheese

Not all cows are equal when it comes to producing milk that is suited for cheese-making. Scientists are close on the trail of the specific genes that code for milk with good curdling ability.

Tinna V. Stevnsner has been given a grant to study how we can ensure that cognitive functions are maintained with age (photo: Lisbeth Heilesen).

2012.12.12 | Public / media, Department of Molecular Biology and Genetics

We live longer, but how are we doing?

The Danish population is getting older and older, and holding on to cognitive functions – such as memory – among the elderly is important for maintaining their quality of life, particularly so because there is no effective treatment as yet – nor any aids – to compensate for the loss of their intellectual capacity. So how do we ensure that…

Sir John B. Gurdon gives a talk at Aarhus University on Monday 17 December 2012.

2012.12.07 | Public / media, Department of Molecular Biology and Genetics

Nobel Laureate makes a stop in Aarhus

Sir John B. Gurdon, University of Cambridge, will be presented next week with the Nobel Prize in Physiology or Medicine 2012. Following a tour around Sweden, he will make a stop at Aarhus University on his way home. On Monday 17 December 2012, he will present his Nobel Lecture.

Suresh Rattan

2012.12.06 | Public / media, Department of Molecular Biology and Genetics

Suresh Rattan granted honorary visiting professorship in the Czech Republic

Suresh Rattan, PhD, Dr.scient. has been granted an honorary visiting professorship at the Faculty of Science, Palacky University in Olomouc, Czech Republic, for a period of four years.

2012.12.03 | Public / media, Department of Molecular Biology and Genetics

Research funding rains millions over MBG

The Department of Molecular Biology (MBG) and Genetics hit the jackpot three times in this round of funding when the Danish Council for Strategic Research announced the projects to funded. A whopping seven out of nine projects which have received support from the Danish Council for Strategic Research’s Programme Commission for Health, Food and…

Photo: Colorbox

2012.12.03 | Public / media, Department of Molecular Biology and Genetics

Milk is good for memory

Researchers at Aarhus University are working on creating a milk-based product that ensures good absorption of vitamin B12. Elderly people in particular are at risk of vitamin B12 deficiency, and this can affect functions such as memory.

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