News

News

The researchers behind the revelation of the surprising interplay between the ends of human genes (from left): Søren Lykke Andersen, Pia Kjølhede Andersen and Torben Heick Jensen (photo: Lisbeth Heilesen)

2012.10.02 | Public / media, Department of Molecular Biology and Genetics

Length matters in gene expression

A research team at Aarhus University reveals a surprising interplay between the ends of human genes: If a protein-coding gene is too short it becomes inactive! The findings also explain how some short genes have adapted to circumvent this handicap.

The research team behind the results showing how how bacteria control the amount of toxin in their cells (from left): Nicholas E. Sofos, Andreas Bøggild and Ditlev E. Brodersen (photo: Lisbeth Heilesen)
The toxins normally bind very strongly to the antitoxins and are thus not only inactive, but also prevent the production of more toxin from the information encoded in the bacterial DNA. During the dormant state, however, the antitoxins are degraded, and the toxins released (step 1). The free toxins now bind to unoccupied antitoxins on DNA within the area encoding the toxin-antitoxin couple (step 2). Binding increasing amounts of toxin eventually leads to the release of the molecules from the gene (steps 3 and 4) and finally to new toxin production (figure: Ditlev E. Brodersen)

2012.09.14 | Public / media, Department of Molecular Biology and Genetics

X-rays reveal the self-defence mechanisms of bacteria

A research group at Aarhus University has gained unique insight into how bacteria control the amount of toxin in their cells. The new findings can eventually lead to the development of novel forms of treatment for bacterial infections.

Atomic model of the complement protein C4 (brown) trapped in the complex with the protein-degrading enzyme MASP-2 (blue). The model shows how the MASP-2 attaches itself to the C4, which allows the MASP-2 to cleave a small portion of the C4. This makes the structure of C4 change, which enables the C4 to bind to the surface of pathogenic microorganisms, for example, or our own dying cells (Figure: Rune T. Kidmose) - click figure for enlargement.

2012.09.10 | Public / media, Department of Molecular Biology and Genetics

Chain reaction in the human immune system trapped in crystals

A research team from Aarhus University has revealed details of how a chain reaction in the human immune system starts. With these results, the researchers hope to promote the development of strategies aimed at alleviating suffering caused by unintentional activation of the immune system.

Atomic model of the haptoglobin-hemoglobin complex exhibiting a barbell-like structure. When strong x-ray is applied on the protein crystals, the radiation is diffracted. By measuring the intensity of diffracted radiation a 3-dimensional map of the atoms can be generated leading to a final model. Click for enlargement

2012.08.31 | Public / media, Department of Molecular Biology and Genetics

Aarhus researchers solve mystery in blood

This week, a Nature paper entitled "Structure of the haptoglobin–haemoglobin complex" is authored by an interdisciplinary crowd of researchers from AU. Associate Professor Gregers Rom Andersen from MBG contributed to the project by determining the crystal structure of the haptoglobin–haemoglobin complex.

2012.08.27 | Public / media, Department of Molecular Biology and Genetics

DKK 15 millioner for a new membrane centre at Aarhus University

A group of researchers at AU have been granted DKK 15 million to create a new research centre to study the body's membrane proteins. The following researchers from the Dept. of Molecular Biology and Genetics participate in the centre: Gregers Rom Andersen, Rune Hartmann, Lene Niemann Nejsum, Poul Nissen, Claus Oxvig og Lea Thøgersen.

In collaboration with French scientists, PhD student Thomas B. Kallehauge (right) and Professor Torben Heick Jensen shed light on a phenomenon where the export of mRNA is corrupted. The study shows that mRNA retained in nuclear dots is translationally active and that such dots may function as nuclear storage sites for immature mRNA (Photo: Estelle Marchal).

2012.08.24 | Public / media, Department of Molecular Biology and Genetics

mRNA quality control mechanism prevents contamination of cells

Researchers from Aarhus University have just disclosed a new quality control mechanism that prevents contamination of cells with aberrant mRNA. This helps us to understand how mRNA quality control can act in a precautionary way to avoid the cellular spreading of toxic molecules.

Figure 1. The researchers have used the carnivorous plant the Venus flytrap (Dionaea muscipula) for their research which has resulted in the so far most comprehensive analysis of the protein composition in the digestive juice of a carnivorous plant, which contribute significantly to the understanding of prey digestion in these plants (Photo: Jan J. Enghild).
Figure 2: Workflow of the Venus flytrap digestive fluid analysis (Figure: Kristian Wejse Sanggard)

2012.08.17 | Public / media, Department of Molecular Biology and Genetics

Prey digestion by the carnivorous Venus flytrap

A newly published study by researchers from Aarhus University provides the most comprehensive analysis to date of the protein composition in the digestive juice of a carnivorous plant, and this contributes significantly to the understanding of prey digestion in these plants. The identified, unique digestive enzymes identified by the researchers…

Professor Peter Andreasen (left) with Professor Ming Dong Huang, Director of the State Key Laboratory of Structural Chemistry at the Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences in Fuzhou, where Peter Andreasen was awarded a visiting professorship.

2012.08.10 | Public / media, Department of Molecular Biology and Genetics

Peter Andreasen awarded visiting professorship in China

Professor Peter Andreasen, Department of Molecular Biology and Genetics, Aarhus University, is awarded a "Visiting Professorship for Senior International Scientists of the Chinese Academy of Sciences in 2012".

The research group behind the identification of new unique cornea proteins. Back row from left: Ebbe Toftgaard Poulsen, Thomas F. Dyrlund, Jan J. Enghild. Front road: Camilla Lund Nikolajsen, Ida B Thøgersen and Carsten Scavenius. Henrik Vorum also participated in the studies. (Photo: Lisbeth Heilesen).
Figure left: Number of overlapping proteins identified in the three layers of the human cornea. A total of 3250 unique proteins were identified, 2737 in the epithelial, 1679 in the stromal and 880 in the endothelial layer. Right: Number of overlapping proteins quantified in the three layers of the human cornea. A total of 771 proteins were quantified, 634 in the epithelial, 342 in the stromal and 140 in the endothelial layer.
Diseased cornea with protein deposits.

2012.06.29 | Public / media, Department of Molecular Biology and Genetics

Identification of new unique cornea proteins

With the identification and quantification of a large number of cornea proteins, a research group at Aarhus University has taken a big step closer to characterising the protein profile required to maintain corneal homeostasis (balance). This information may be used for exploring the basic molecular mechanisms involved in corneal health and…

Figure. Structural analysis of 12ADT=Asp binding to SERCA pump. (a) 12ADT=Asp bound to SERCA pump (blue) demonstrating predominant binding of TG pharmacophore (yellow space filling) to the transmembrane domain with extension of the Asp moiety (green) into the space between the ?-helices making up the transmembrane domain. (b) the ?-amine group of the Asp moiety forms a hydrogen bond with Gln 250 of the SERCA pump (residue shown in stick representation) and potential interaction with phospholipid. (c) the Asp moiety of 12ADT=Asp (yellow) occupies a similar site in the SERCA as the known SERCA pump inhibitor CPA (aquamarine). b,c Colour code: Transmembrane (TM) 1-2 purple, TM3-4 green, TM5-6 orange, TM7-10 wheat, P-domain blue, A-domain yellow, Asp-ADT yellow, phosphatidylethanolamine (PE) aquamarine, electron density 2Fo-Fc grey (contour level 1 sigma), hydrogen bond grey, CPA aquamarine (figures: Ingrid Dach)

2012.06.28 | Public / media, Department of Molecular Biology and Genetics

New cancer drug shows great promise

Danish researchers have developed a new drug against prostate cancer in collaboration with researchers from Johns Hopkins University and the biotech company Genspera in the USA.

Manfred Schmid (left) and Torben Heick Jensen have revealed a function in gene expression regulation for a protein connected with the proper function of neurons. Further analysis of this unexpected function of protein binding may ultimately lead to the understanding of how neurological defects occur with abnormalities in this protein. Click figure for enlargement  (Photo: Lisbeth Heilesen)
Figure: Poly(A) tails (a stretch of adenosine ‘A’ residues) are added at the end of the RNA (black line) by an enzyme called Pap1 (dark green oval symbol) and the tails are bound by the proteins Pab1 (light-green diamond symbol) and/or Nab2 (red circle symbol). In normal ‘wild-type’ cells (wt, left panel), the poly(A) tail is bound by Pab1, whereas Nab2-binding is prevented by Rrp6 (orange PacMan symbol). In addition, Rrp6 counteracts the action of the TRAMP complex (dark blue oval), which can extend tails beyond normal length. Both functions are revealed in mutant yeast cells lacking Rrp6 (rrp6?, right panel), where Nab2 does bind poly(A) tails and TRAMP extends poly(A) tails beyond their normal length (hyperadenylation). Click figure for enlargement (Figure: Manfred Schmid).

2012.06.08 | Public / media, Department of Molecular Biology and Genetics

Surprising new mechanism for gene expression regulation

New research results reveal a function in gene expression regulation for a protein connected with the proper function of neurons. Further analysis of this unexpected function of protein binding may ultimately lead to the understanding of how neurological defects may result from abnormalities in this protein.

Professor Torben Heick Jensen. Click photo for enlargement. Photo: Lisbeth Heilesen

2012.05.09 | Public / media, Department of Molecular Biology and Genetics

Great international recognition of Torben Heick Jensen

Professor Torben Heick Jensen, Department of Molecular Biology and Genetics, Aarhus University, has achieved great international recognition with his nomination as a member of the European Molecular Biology Organization (EMBO). The election to EMBO is in recognition of Professor Jensen’s outstanding research within gene expression.

Michael Jakob Voldsgaard Clausen

2012.05.01 | Public / media, Department of Molecular Biology and Genetics

Unique pump in sperm cells makes a difficult journey possible

In his PhD work, Michael Jakob Voldsgaard Clausen made a detailed study of a molecular pump that is essential for sperm cells and is not found in other types of cells.

10 piglets, born using frozen boar semen, will reduce inbreeding in the Danish Landrace 1970, and thus contribute significantly to perpetuating the breed for the future. Photo: Anne Møller Christensen

2012.04.18 | Public / media, Department of Molecular Biology and Genetics

Renaissance of the Danish ‘Bacon Pig’

The Danish Landrace 1970 – also known as the ‘Bacon Pig’ – has received a genetic boost. By using frozen semen, “old” genes have successfully been re-introduced to the breed. This has huge impact on the preservation of the breed.

Lasse Bohl Jenner was awarded the prestigious grant of DKK 11 million to study how regulation and localisation of the ribosome – and thereby protein synthesis – is used by the organism to control areas such as the establishment of long-term memory, general cell development and tissue differentiation. Click photo for enlargement. Photo: Lisbeth Heilesen

2012.04.12 | Public / media, Department of Molecular Biology and Genetics

Prestigious grant of DKK 11 million to molecular biologist

The Novo Nordisk Foundation has awarded the prestigious Hallas-Møller Scholarship valued at DKK 11 million to Lasse Bohl Jenner (41) to study how regulation and localisation of the ribosome – and thereby protein synthesis – is used by the organism to control areas such as the establishment of long-term memory, general cell development and tissue…

Showing results 226 to 240 of 273

Previous 7 8 9 10 11 12 13 14 15 16 Next