During DNA replication, single-stranded breaks in the genome will be converted to double strand breaks. Such breaks are normally repaired by a very imprecise mechanism, which may incorporate mistakes in the genome (here shown as red stretches of DNA). To avoid too many mutations, a nuclease called Mus81 acts at these positions to decrease the distance, where the imprecise mechanism is used (Photo: Colourbox; drawing: Lotte Bjergbæk)

2015.08.24 | Research

Identifying mechanism that repairs damage to our genome

One of the most common forms of damage to our genome is a break in one of our DNA strands. Researchers have now found a mechanism that can repair these breaks naturally and thereby help to suppress the development of cancer.

Figure A. Methyl phosphate. B. Methyl phosphonate. Phosphonate compounds are characterised by a direct link between carbon (C) and phosphorus (P), marked with red. C. The molecular structure of the C-P lyase complex (Figure: Ditlev E. Brodersen, Aarhus University)
The Danish research team behind the article in <em>Nature</em>; from left: Bjarne Jochimsen, Lan Bich Van, Morten Kjeldgaard, Paulina Seweryn, Bjarne Hove-Jensen and Ditlev E. Brodersen (Photo: Lisbeth Heilesen, Aarhus University)
The British research team: Lori A. Passmore and Christopher J. Russo (Photo: Martin Phelps, Medical Research Council, Cambridge)

2015.08.17 | Research

Bacteria’s secret weapon against pesticides and antibiotics revealed

Bacteria exhibit extreme adaptability, which makes them capable of surviving in the most inhospitable conditions. New research results produced by Danish and British researchers now reveal the molecular details behind one of the secret weapons used by bacteria in their battle to survive under very nutrient-poor and even toxic conditions.

<strong>Uninfected and infected root nodules</strong>. Uninfected root nodule induced by <em>M. loti</em> bacteria synthesising incompatible exopolysaccharides (left) and infected nitrogen fixing root nodule induced by <em>M. loti</em> bacteria synthesising compatible exopolysaccharides (right). (Figure: Yasuyuki Kawaharada, Aarhus University).
The research team behind the new research results in <em>Nature</em>from Denmark, New Zealand and the USA. (Photo: Lisbeth Heilesen, Aarhus University).

2015.07.08 | Research

Researchers discover how bacteria sweet-talk their way into plants

An international team of researchers has discovered how legumes are able to tell helpful and harmful invading bacteria apart. The research has implications for improving the understanding of how other plants, animals and humans interact with bacteria in their environment and defend themselves against hostile infections. These findings can have…

Nuclear mRNA with a poly(A) tail is normally bound by Nab2, exported to the cytoplasm for translation into proteins and finally turned-over as shown on the left. In the absence of Nab2, the RNA is unprotected and degraded already in the nucleus by exoribonucleases Rrp6 and Dis3. Figure: Manfred Schmid.

2015.06.26 | Research

Surprising new mechanism for gene expression regulation

A new important role for a protein connected to the proper function of neurons has been discovered by a research group from MBG, Aarhus University. The studies shed new light on gene expression regulation and may ultimately lead to an understanding of how neurological defects occur when this protein is mutated.

The figure shows nodules colonised by the symbiont (in green) and by the endophyte (red). Both symbionts and endophytes get access into the nodule via infection threads induced by the symbiont. The endophyte colonises efficiently intra and intercellular spaces of the nodule.

2015.06.22 | Research

Legumes control infection of nodules by both symbiotic and endophytic bacteria

New research results show that legume plants selectively regulate access and accommodation of both symbiotic and endophytic bacteria inside root nodule. This provides a solid basis and platform for identification and selection of beneficial endophytic bacteria and highly efficient nitrogen-fixing rhizobia to be used as biofertilisers in…

Bjørn Panyella Pedersen (Photo: Lisbeth Heilesen)
Four recipients of ST Awards 2015 together with the dean. Pictured from left are Peter Frank Tehrani (ST Education Award 2015), Dean Niels Chr. Nielsen, Inga Jensen Mumm (ST TAP Award 2015), Esben Auken (ST Industrial Collaboration Award 2015) and Bjørn Panyella Pedersen (ST Science Award 2015). Mie Birkbak (ST Talent Award 2015) was on a research period abroad. (Photo: Peter Gammelby, ST Communication).

2015.06.22 | Awards

Bjørn Panyella Pedersen receives ST Science Award 2015

Every year in June, ST selects six people to receive an award in recognition of their great efforts – generally and during the year that has passed – and Bjørn Panyella Pedersen from the Department of Molecular Biology and Genetics receives ST Science Award.

2015.06.10 | Grant

Nine researchers from MBG receive grants from the Danish Council for Independent Research

Rune Hartmann, Gregers Rom Andersen, Claus Oxvig, Daniel Otzen, Lene Niemann Nejsum, Esben Skipper Sørensen, Jørgen Kjems and Ebbe Sloth Andersen have all received a large grant from the Danish Council for Independent Research.

The image shows which parts of the GlpG protein are the first to fold in the transition state (TS). The greener it is, the more coloured it gets. White shows that there is no structure in the TS, while red shows that this part of the protein has ‘overfolded’. Left: the actual 3D structure of the protein. Right: here the individual amino acid residues are shown in a model overview of the protein, where all 6 transmembrane helices (TM1–6) are visible, as well as the two helices (H1–2) and the loop, which is sticking out of the cell membrane.

2015.06.09 | Research

All folding is good when it gets off to a good start

Aarhus researchers are behind the most detailed description of how membrane protein folds. This provides new knowledge about the wonderful world of membrane proteins.

The research team behind the research that led to the ”Early Career Grant” from DuPont to Bjørn Panyella Pedersen. From left: Line Lindgreen Eriksen, Bjørn Panyella Pedersen and Peter Aasted Paulsen. (Photo: Lisbeth Heilesen).

2015.06.09 | Grant

Bjørn Panyella Pedersen awarded DuPont Early Career Grant

Assistant Professor Bjørn Panyella Pedersen, Department of Molecular Biology and Genetics at Aarhus University, has been awarded the highly prestigious "Early Career Grant" from DuPont.

2015.06.03 | Grant

Collaborative research will contribute to improved vitamin B12 uptake

In an interdisciplinary collaboration involving basic biological research and clinical trials, Danish and Indian researchers seek an explanation of why vitamin B12 absorbed more efficiently from milk compared with equivalent amounts of B12 in other food. In collaboration with Arla Foods Ingredients Group P / S and the NGO The Global Alliance for…

Danish and Canadian researchers have uncovered important molecular details about the regulation of the cell biosynthesis-machinery during cellular stress. This knowledge has implications for anti-cancer treatment, since the implicated factors are key regulators of cell growth and proliferation.
Figure 2: LARP1 represses TOP mRNA translation downstream of mTOR. The left panel illustrates how TOP mRNA remains translated during normal growth conditions, where both LARP1 and eIF4E-BP1 (4E-BP1) are phosphorylated (P). This allows eIF4F (includes eIF4E, eIF4G and eIF4A) to interact with the cap-structure (m7Gppp) on the mRNA and effectively recruit the ribosome (40S/60S). The right panel shows stress conditions where LARP1 and eIF4E-BP1 are active (non-phosphorylated). These proteins will interact with eIF4E and the TOP sequence, respectively, which in turn occludes eIF4G association with the complex and translation becomes inefficient. The study also demonstrates that LARP1 stabilizes TOP mRNAs. Figure: Bruno Fonseca and Christian Damgaard

2015.05.22 | Research

New insights into fundamental stress-regulated cellular processes

Danish and Canadian researchers have uncovered important molecular details about the regulation of the cell biosynthesis-machinery during cellular stress. This knowledge has implications for anti-cancer treatment, since the implicated factors are key regulators of cell growth and proliferation.

The researchers intend to study whether there is evidence that certain genes can affect healthspan, and if so, which genes. Figure: Suresh Rattan.

2015.05.19 | Grant

The key to healthy ageing

In order to increase the quality of life, a group of researchers from the Laboratory of Cellular Ageing at Aarhus University, and their foreign collaborators intend to find the factors that influence health, ageing and longevity. The new project is supported by the EU with a grant amounting to Euro 7 million.

A newly developed method that combines phase extraction with an enzymatic reaction may eventually be used for an improved and faster screening analysis of isatin as a potential indicator of stress and neurological disorders. Figure: J. Preben Morth and Lisbeth Heilesen.

2015.05.11 | Research

Method for determining possible stress marker in blood samples

A research collaboration between the universities of Oslo and Aarhus has resulted in the development of a new method with diagnostic potential. The new method that combines phase extraction with an enzymatic reaction may eventually be used for an improved and faster screening analysis of isatin as a potential indicator of stress and neurological…

To the left, an illustration of the principle behind Spiegelmers. Normal aptamers are formed from D-nucleotides also used for RNA and DNA, whereas the Spiegelmers are constructed from L-nucleotides. The two molecules are therefore perfect mirror-images of each other. To the right is shown the three-dimensional structure of the Spiegelmer from the German company NOXXON Pharma AG bound to the inflammatory protein C5a determined by the scientists at Aarhus University through X-ray crystallography. Figure: Laure Yatime.

2015.05.05 | Research, Knowledge exchange

Aarhus scientists look through the mirror to reveal the secrets of a new drug

Research results from Aarhus University can help develop anti-inflammatory drugs.

Improvement of cow feed efficiency through new genetic methods can protect the environment and boost the farmer's economy. Photo: Jesper Rais

2015.03.23 | Grant, Knowledge exchange

Towards low-impact high-yielding cows

Burps, behaviour, blood and milk are some of the traits that can give us an indication of how efficient and eco-friendly a cow is. Scientists at Aarhus University are developing tools that can identify the most cost-effective cows. This will benefit the farmer’s economy and the environment.

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