The changes in the red and blue bands show the recently discovered local unfolding of PAI-1 just before it is inactivated. Also shown is how the green parts of proteins are rearranged in connection with the inactivation. Figure: Morten Beck Trelle and Peter A. Andreasen

2014.07.30 | Research

Breakthrough in exploration of protein dynamics

Using a uniquely informative technology, a team of Danish researchers has discovered a new type of peptide chain dynamics that controls the stability of the PAI-1 protein. The discovery provides a better basis in the long term for intervening in diseases associated with increased risk of blood clots.

With a new method, researchers use a piece of DNA engineered to bind to metal ions. Using this ‘control stick’, they direct another piece of DNA to a metal binding site on the protein. Illustration: Nature Chemistry

2014.07.30 | Research

New method provides researchers with efficient tool for tagging proteins

Aarhus University researchers have developed an easier method to create DNA–protein conjugates. The method can potentially strengthen the work involved in diagnosing diseases.

The genetics of several cattle breeds is now described in hitherto unseen details. Photo: Colourbox

2014.07.30 | Research

Cattle code cracked in detail

The cattle genome has now been mapped to a hitherto unknown degree of detail. This constitutes a quantum leap for research into the history and genetics of cattle.

The Danish research team behind the new results (from left): Jan K. Jensen, Michael Etzerodt, Anette Kjems and Bjarne Jochimsen (photo: Lisbeth Heilesen)
The Norwegian research team: Kaare Bjerregaard-Andersen, J. Preben Morth and Theis Sommer (photo: Oslo University)
Identification of two entrances to the active site, a combined water and proton channel and a substrate and product channel (figure: Kaare Bjerregaard-Andersen)

2014.06.30 | Research

Norwegian - Danish collaboration uncovers proton channel in a bacterial enzyme

A scientific collaboration between researchers from the University of Oslo and Aarhus University has revealed an unexpected channel for removal of protons in the enzyme isatin hydrolase.

At the beginning of an infection, the viral RNA is released inside the cell. The cellular protein RIG-I detects the viral RNA and initiates a defence mechanism that leads to the expression of the protein OASL. Later during the infection – when OASL is present in the infected cell – RIG-I recognises the viral RNA again , but by interacting with OASL, the initiated defence mechanism is enhanced, thereby fending of the virus more efficiently.

2014.06.23 | Public / media

Viral infections could be stopped by boosting natural protein

An international research team has published results showing that boosting the protein OASL may help the body to detect and fend off certain viral infections on its own. The discovery could lead to new, more effective treatments for many dangerous viruses such as hepatitis C and influenza.

2014.06.23 | Awards

Thomas Birkballe receives ST Science Award 2014

During ST's summer celebration on 20 June 2014, six ST awards were given. Postdoc Thomas Birkballe Hansen from MBG/iNANO received the ST Science Award.

Bjørn Panyella Pedersen (Photo: the Danish Council for Independent Research)
Sapere Aude: DFF-research leaders with Chairman of the Board Peter Munk Christiansen and Minister of Research Sofie Carsten Nielsen. Bjørn: front row, no. two from the right. (Photo: the Danish Council for Independent Research)

2014.06.18 | Public / media

Sapere Aude grant awarded to Bjørn Panyella Pedersen

With a Sapere Aude Starting Grant of more than DKK 7 million from the Danish Council for Independent Research, Bjørn P. Pedersen is assured of the best possible chance to return to Denmark and establish a structural biology research group at Aarhus University.

2014.06.18 | Public / media

Six researchers from MBG receive grants from the Danish Coucil for Independent Research

Jan J. Enghild, Kim Henrik Hebelstrup, Ian Max Møller, Lene Niemann Nejsum, Daniel Otzen and Claus Oxvig from MBG have all received large grants from The Danish Council for Independent Research.

The novel online learning platform has been developed to support the written exam skills of university students.
Associate Professor Ditlev Egeskov Brodersen from the Department of Molecular Biology and Genetics has developed the novel learning platform that will now be opened up to a wider audience at Aarhus University and other institutions in Denmark and abroad. Photo: Inger Marie Lindeman Olsen.

2014.06.11 | Public / media

Novel learning platform developed at AU

Today, Wednesday 11 June 2014, a novel learning platform is launched at Aarhus University, The platform has been developed by Associate Professor Ditlev Egeskov Brodersen at the Department of Molecular Biology and Genetics (MBG) and will be presented to the public on Thursday afternoon at a workshop at the conference "Frontiers in…

Deep roots help crops acquire water and nutrients. With the aid of new gene technologies scientists are developing crops with deeper roots. Photo: Colourbox

2014.06.10 | Public / media, Knowledge exchange

Deep roots are the root of all good

Scientists are developing deep-rooted crops for better uptake of water and nutrients. This will make the plants more robust and better able to cope with the expected effects of climate change on the weather and will ensure better growth and higher yields.

New gene technologies will be used to make Danish malt barley even better. Photo: Colourbox

2014.06.10 | Public / media, Knowledge exchange

Better beer with better barley

New genetic technologies have revolutionised animal breeding. Now the same technologies and models can be used to better Danish malting barley.

The velvet spider’s genome has now been mapped. This image shows a group of social velvet spiders jointly killing their prey. Photo: Peter Gammelby, Aarhus University.
Kristian Wejse Sanggard and Jesper Smærup Bechsgaard with a tarantula. Photo: Peter Gammelby, Aarhus University.
We now know more about the tarantula. Its silk and venom are particularly interesting for the researchers. Photo: Aarhus University.

2014.05.06 | Public / media

Mapping the spider genome

For the first time ever, a group of Danish and Chinese researchers has sequenced the genome of the spider. This knowledge provides a much more qualified basis for studying features of the spider. It also shows that humans share certain genomic similarities with spiders.

The research team behind the new results of muscular dystrophy (from left): Thomas G. Jensen, Rune Thomsen, Olof Pettersson, Lars Aagaard og Christian Damgaard (Diana Andrejeva is missing in the photo). Photo: Lisbeth Heilesen.
Figure 1. Cells isolated from muscular dystrophy patients are stained for the toxic RNA (red), which is often seen in the cell nucleus (marked blue). Figure: Christian Damgaard.
Figure 2. Left: The toxic RNA in DM1 cells consists of a number of CUG triplets that are often repeated thousands of times, forming a specific structure as shown. The MBNL1 protein binds to this structure, thus failing to carry out its normal function in the cell. The expression of a number of genes becomes deregulated in the cell and the disease occurs. Right: DDX6 can ‘unwind’ the structure with its enzyme activity and MBNL1 leaves the complex to carry out its normal functions in the cell. Figure: Christian Damgaard

2014.05.04 | Public / media

New knowledge about muscular dystrophy

Researchers at Aarhus University have revealed a previously unknown function of a cellular enzyme that can disperse toxic aggregates in the cells of patients with muscular dystrophy.

A detailed picture of the enemy has been drawn
Professor Daniel Otzen. Photo: Peter F. Gammelby
An oligomer -the figures indicate the size in nanometres, i.e. in billionths of a metre

2014.04.28 | Public / media, Department of Molecular Biology and Genetics

Know your enemy!

Researchers at Aarhus University have drawn up the most detailed ‘image of the enemy’ to date of one of the body’s most important players in the development of Parkinson’s disease. This provides much greater understanding of the battle taking place when the disease occurs – knowledge that is necessary if we are to understand and treat…

The discovery of Factor XIII's many roles was done by a research team from Aarhus University's Department of Molecular Biology and Genetics - Protein Science. From left: PhD student Ebbe Toftgaard Poulsen, PhD student Camilla Lund Nikolajsen, Postdoc Carsten Scavenius, Professor Jan J. Enghild and PostdocThomas F. Dyrlund. Photo: Lisbeth Heilesen
A lump of coagulated blood. On the scanned electronmicroscopy, red blood cells are shown (and one white) spun into a network of fibrin. The image is computer-coloured in red and yellow. Photo: David Gregory & Debbie Marshall, Wellcome Images (license:

2014.04.24 | Public / media, Department of Molecular Biology and Genetics

Researchers study the secrets of blood

The factors controlling blood coagulation have been known for a long time. New research shows that the last factor – Factor XIII, which stabilises the healing process – plays a much more complicated role than previously thought.

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