Megan Yi-Ping Ho


iDEAs: Innovation, Design, Engineering, Application in Single-Cells

iDEAs, where the engineering and biology meet

iDEAs’ goal is to establish a single cell platform to study the “nano-bio” interface and how cell fate is altered by environmental and therapeutic stimuli. Ultimately, the generated knowledge will lay the foundation for future medicine on both diagnostics and therapeutics.

Cellular heterogeneity is intrinsic to many cell-fate processes; however, traditional biological analysis often relies on averaged phenotypic information and overlooks the heterogeneous responses among cells. In iDEA, we focus on the study of molecular and cellular dynamics in a single cell manner. Particularly, we would like to address issues on the “nano-bio” interface, where synthetic therapeutic materials are in contact with biological components. The merit will eventually provide us the capability to design and modify nanomaterials tackling assorted biological problems and upcoming clinical challenges.

Three major themes in iDEAs are:

  1. Nanomedicine-on-a-chip
  2. Single-Cell Molecular Imaging
  3. Biophysical Interactions at the Nano-Bio Interface

More information about the group:

Research overview