Structural and Functional Studies of Membrane Transporters in Brain
Structure and function of membrane proteins, P-type ATPases and secondary transporters, protein-protein and protein-lipid interactions of biomembranes, neurobiology, calcium signaling, Na+,K+-ATPase, neurotransmitter transporters, structure-based biotechnology and drug discovery, single-molecule studies.
Poul Nissen's group investigates molecular mechanisms of membrane transport processes and biomembrane structure. Activities are mainly focused on protein crystallography, biochemistry, electrophysiology, and include also small-angle X-ray scattering and electron microscopy. Main subjects of research concern P-type ATPase (ion pumps and lipid flippases) and Na+ dependent transporters, but include also structure based drug discovery and protein engineering.
The main focus of our research is to investigate the membrane transporters involved with neurological and psychiatric disorders. The Na+, K+-ATPase is of particular interest, since many neurological disorders are linked to the function of this pump, such as function loss in the Na+,K+-ATPase that can lead to severe diseases such as familial hemiplegic migraine and rapid-onset Dystonia with Parkinsonism.
Several different methods are used to study membrane pumps in our research group, such as structural studies including use of nanodiscs, electrophysiology, and hypoxic conditions.
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