We are a structural biology research lab focusing on the molecular mechanisms underlying RNA maturation, processing, and decay in eukaryotic organisms.
In the lab we use molecular biology, biochemistry, and x-ray crystallography to study the structure and function of a number of important protein and RNA macromolecules involved in regulation and decay of RNA in both the nuclear and cytoplasmic compartments of the eukaryotic cell. Research projects focus on several aspects of controlled 3'-5' degradation of mRNA via the nuclear exosome and cytoplasmic decay processes, such as deadenylation. We use both bacteria and yeast as model systems to study molecules which are widespread in nature, from the simplest living beings to man. You can read more about our research projects.
Our lab is part of the Danish National Research Foundation's Centre for mRNP Biogenesis and Metabolism at the Aarhus University in Denmark. We're also a part of the Centre for Structural Biology in Aarhus, one of the largest structural biology facilities in the Nordic countries.
Controlled degradation of RNA is of central importance, not only for the overall rate of gene expression, but also for the complex surveillance mechanisms that ensure a high quality of both mRNA and stable RNAs.
We are interested in the molecular and structural mechanisms behind controlled RNA degradation and RNA quality control in eukaryotes. Research is currently being carried out within the following main topics:
Some of the questions we are interested in answering are:
Recent highlights from our lab include the structure determination of the yeast nuclear exosome component, Rrp6p, which is required for both trimming of stable rRNA species as well as for early mRNA surveillance, and the structural and functional characterisation of the S. pombe Pop2p deadenylation subunit, critically involved in removal of the poly(A) tail of mRNAs at the onset of degradation.
Students and post docs interested in the projects are very welcome to contact Ditlev Brodersen for further information and a visit to the lab.
As a student in the group, you will be able to work with