We are interested in how mTOR and ATR signalling works at the atomic level. mTOR is a major regulator of cell metabolism and ATR regulates the DNA-damage response, and even though these two kinases exert very different biological functions they likely share some of the same regulatory principles. We use X-ray crystallography and cryo-electron microscopy (cryo-EM) to gain molecular insights of these molecules and use in vivo and in vitro experiments to test our structures and get a deeper understanding of their functions. Ultimately we want to understand how these signalling pathways contribute to diseases like cancer and diabetes.
If you are interested in our work and would like to join, please contact Kasper Røjkjær Andersen (email@example.com).