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Infection and Immunity Seminar: Andres Ablasser: The role of the immunological DNA sensor cGAS in infection and disease

Foreign DNA is highly immunostimulatory, and activates several signaling pathways to promote both antimicrobial defense and inflammation. Andrea Ablasser has played a leading role in this rapidly developing field. In her seminar Andrea will give an introduction to this fascinating field, and will highlight her key findings and talk about some of her recent and unpublished results.

18.10.2016 | Lisbeth Heilesen

Dato ons 26 okt
Tid 11:15 12:00
Sted The Lakeside Lecture Theatre - William Scharff auditorium

 

Andres Ablasser. Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

The role of intracellular DNA sensing through cGAS during infection and
beyond

Sensing of foreign nucleic acids is a major strategy by which the innate immune
system senses viral infection. Distinct receptor systems for viral RNA and DNA have
been identified that upon engagement with their ligand trigger potent antiviral
responses, including the production of type I interferons (IFNs). In the cytosol
members of the RIG-I-like helicases detect viral RNA, whereas the presence of
cytosolic dsDNA is sensed by cGAS. Upon activation cGAS catalyzes the synthesis of
the 2nd messenger cGAMP, which in turn engages the ER-resident receptor STING
to induce the transcriptional up-regulation of type I IFNs and to promote an
antiviral state. Recently, we have demonstrated that cGAS becomes activated in
the context of infection with Mycobacterium tuberculosis. In this talk an up-date
will be given on our latest progress on elucidating the functional role of self DNA
sensing by cGAS and STING in mammalian cells.

Key publications from Andrea Ablasser:

  • Cell Host Microbe. 2015 Jun 10;17(6):799-810
  • Nature. 2013 Nov 28;503(7477):530-4. 
  • Nature. 2013 Jun 20;498(7454):380-4. 
  • Nat Immunol. 2009 Oct;10(10):1065-72
  • Nature. 2009 Mar 26;458(7237):514-8.
Arrangement