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Seminar: Yanick Crow: Human type I interferonopathies

05.05.2015 | Lisbeth Heilesen

Dato fre 08 maj
Tid 11:15 12:00
Sted Eduard Biermann Aud. (1252-204)

Type I Interferon (IFN) is a major antiviral cytokine, which is induced through innate immune receptors detecting foreign nucleic acids. However, uncontrolled production of IFNs is associated with pathology. Aicardi-Goutières syndrome (AGS) is a genetically-determined brain disease closely mimicing the sequelae of congenital infection. AGS and congenital viral infection are both associated with an increased production of type I IFN. Furthermore, a disturbance of Type I IFN homeostasis is considered central to the pathogenesis of the autoimmune disorder systemic lupus erythematosus (SLE). In keeping with this, some children with AGS develop an early-onset form of SLE. Professor Yanick Crow has been the leading figure in the field unraveling how defects in the genes encoding proteins of the cellular nucleic acid metabolic system leads to IFN-driven pathology (“interferonopathies”). In the talk Dr. Crow will give a description of the current knowledge on IFN-driven pathology, and present data from recent/ongoing studies on the genetics and mechanisms underlying interferonopathies in humans.

Professor Yanick Crow, Manchester Centre for Genomic Medicine, University of Manchester (www.manchester.ac.uk/research/Yanick.crow/personaldetails)