Anja E. Pen: Gene Modification in Honeybee and Pig
PhD defense, Friday 14 September 2018, Anja E. Pen.
During her studies, Anja investigated different ways to genetically modify honeybees and pigs. For the first time, she combined the new CRISPR-Cas9 technique and sperm-mediated gene transfer (SMGT) in her research laboratory to introduce genetic alterations in these animals. This provides new avenues to research the development of the worker and queen castes in honeybees. Using the same techniques Anja aimed to produce human disease models in pigs. Her goal was to establish an amyotrophic lateral sclerosis (ALS) disease model in pigs by altering the SOD1 gene.
The PhD degree was completed at the department of Molecular Biology and Genetics, Science and Technology, Aarhus University.
This resume was prepared by the PhD Student
Time: Friday 14 September, at 9.00
Place: AU, Foulum, Blichers Alle 20, Tjele, meetingroom 2
Title of PhD thesis: CRISPR-Cas9 gene editing in honeybee and pig
Contact information: Anja Pen, anja.pen@mbg.au.dk, +45 28 99 36 44
Members of the assessment committee:
Professor Kåre Lehmann Nielsen, Department of Chemistry and Bioscience, Section for Biotechnology, Aalborg University
Researcher Bjørn Høyheim, Department of Basic Sciences and Aquatic Medicine, Norwegian University of Life Sciences
Associate Professor Ernst-Martin Füchtbauer, Department of Molecular Biology and Genetics, Aarhus University (chair)
Main supervisor:
Associate Professor Bo Thomsen, Department of Molecular Biology and Genetics, Aarhus University
Co-supervisor:
Professor Christian Bendixen, Department of Molecular Biology and Genetics, Aarhus University
Language: The PhD thesis will be defended in English.