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PhD defense

Katarzyna Kjøge: Analysis of proteases and inhibitors involved in blood coagulation and fibrinolysis

PhD defence, Friday 24 September 2021. Katarzyna Kjøge.

Katarzyna Kjøge

During her PhD studies, Katarzyna Kjøge studied the proteases and inhibitors involved in blood coagulation and fibrinolysis. When a blood vessel is damaged, blood coagulation is initiated. This process leads to the formation of a fibrin and platelet plug that serves to prevent blood loss. When the underlying tissue has healed, the plug is dissolved by the fibrinolytic system. In rare cases, these systems are disturbed and lead to the formation of unwanted blood clots or bleeding tendencies. Katarzyna Kjøge has structurally and functionally characterised two proteins involved in blood coagulation and fibrinolysis: ?2-macroglobulin (A2M) and thrombin-activatable fibrinolysis inhibitor (TAFI). Katarzyna Kjøge has also examined how mass spectrometry can be used to investigate disturbances in these systems.

The research findings contribute to the understanding of the proteins A2M and TAFI, and is a step towards new tools for the clinical investigation of blood coagulation.

The PhD study was completed at the Department of Molecular Biology and Genetics, Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time:
 Friday, 24 September 2021 at 13:15.

Place: The PhD defence will be held online. To receive a link to the event, please send an e-mail to Helle Homan; heho@mbg.au.dk

Title of PhD thesis: On the proteases, inhibitors, and proteolytic events of blood coagulation and fibrinolysis

Contact information: Katarzyna Kjøge, e-mail: kkjoege@mbg.au.dk, tel.: +45 27110280

Members of the assessment committee:
Associate Professor Allan Stensballe, Department of Health Science and Technology, Aalborg University, Denmark

Professor Heiko Herwald, Department of Clinical Sciences, Lund University, Sweden

Professor Ditlev Brodersen (chair), Department of Molecular Biology and Genetics, Aarhus University, Denmark

Main supervisor:
Professor Jan J. Enghild, Department of Molecular Biology and Genetics, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.
Due to the coronavirus situation, the PhD thesis will not be available for reading at the offices of the PhD administration. Instead, interested parties may send an e-mail to gradschool.nat@au.dk to receive a digital copy of the PhD thesis. Please note, it may in certain cases be necessary to make an individual arrangement to read the PhD thesis.