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Dual Roles of ZC3H18 in Nuclear RNA Metabolism. Schematic representation of the dual engagement of ZC3H18 in RNA transcription and decay processes.  Left: ZC3H18 interacts with the CBCA complex (CBC and the ARS2 protein) to regulate protein-coding gene transcription directly or indirectly. The question mark indicates the elusive role of the histone-interacting domain and its modification in facilitating ZC3H18 function.  Right: Short non-coding RNAs, exemplified here by 3’extended snRNAs, are targeted by ZC3H18 in a process requiring interaction with both the CBCA and NEXT complexes. Such RNA decay can also occur ZC3H18-independently via direct NEXT exosome targeting. C, CBCA-interacting domain; H, histone-interacting domain; N, NEXT-interacting domain.

2018.01.03 | Research

Researchers reveal dual role for human RNA decay factor

Researchers at Aarhus University have characterized the human RNA decay factor ZC3H18 and discovered its unanticipated role in the production of protein-coding RNA. The new study, published this week in Cell Reports, therefore reveals a double-faced activity of ZC3H18 in nuclear RNA fate decisions.

Figure caption: Left: Unsharpened (transparent light blue) and sharpened (solid) cryo-EM density maps of human TRPM4 in nanodiscs as viewed from the side. The ion channel is composed by four domains which are colored in each their solid color. Middle: Ribbon diagram of human TRPM4. A calcium binding site belonging to one of the monomers is marked with a box. Right: A zoom-in on the calcium binding site with the coordinating residues represented by sticks and their helices in ribbons. The ribbon diagram is overlaid with the densities of the calcium structure (gray mesh) and the difference density (blue mesh) between the calcium-bound structure and the calcium-free structure. Figure: Henriette Autzen.
Henriette Elisabeth Autzen, who is employed as a postdoc at the Department of Molecular Biology and Genetics at Aarhus University in Denmark, is stationed at the University of California, San Francisco, USA, where she and her American colleagues have published their determination of two structures of the human calcium-activated cation channel, TRPM4, in <em>Science</em>. Photo: University of California, San Francisco.

2017.12.15 | Research

A Channel in the Heart of the Matter

How cells control the movement of ions, electrically charged species, in and out of the cell is a grand puzzle, whose completion will allow a thorough fundamental understanding of human physiology. A Danish-American team of researchers has found a piece of the puzzle with their determination of two structures of the human calcium-activated cation…

Bill Gates (on the right side of the table, in the middle) listening to the researcher’s plans for their research. The head of the project from Aarhus University, Professor Jens Stougaard, is seen on the left side of the table, 2nd from the left. Photo: ©Bill & Melinda Gates Foundation/Alain Brin.

2017.12.11 | Research, Knowledge exchange

Bill Gates met with researchers from Aarhus University

Bill Gates recently met with researchers from the Department of Molecular Biology and Genetics at Aarhus University to discuss the sustainable use of biological nitrogen fixation that allows legumes to use atmospheric dinitrogen as a nitrogen source.

Suresh Rattan

2017.11.30 | People

Suresh Rattan conferred an honorary professorship in Poland

Suresh Rattan Ph.D., Dr.scient. has been awarded an honorary professorship at the University of Rzeszów in Poland.

Adult fish in the zebrafish facility at the Department of Molecular Biology and Genetics, AU. Photo: Lisbeth Heilesen.
Comparison of ECG traces from humans and from two-day old zebrafish. The zebrafish ECG shows the same characteristics as the human ECG, making it possible to measure the QT interval. The blue trace represents a normal zebrafish ECG, the red trace displays short QT. Figure: Vladimir Matchkov and Christian Aalkjær.

2017.11.26 | Research

Zebrafish used to identify disease mechanism for heart disease

In a large collaborative study between the Department of Clinical Medicine, the Department of Biomedicine, and the Department of Molecular Biology and Genetics, among others, the researchers have succeeded in identifying and characterising the consequences of a newly discovered mutation associated with cardiac arrhythmia.

Förster resonance energy transfer (FRET) combines laser light and ultra-sensitive cameras that send signals into an individual molecule. This signal spreads to the other colour molecule on the pump, which begins to transmit light of another colour. The group focuses on the relationship between the different colours, which is registered in a specially built light microscope. These measurements provide information about the pump’s movements. (Photo: Mateusz Dyla)
Illustrated here is the timeline for the pump function, which is now revealed in high time resolution. The curve shows the relationship between the measured fluorescent colours emitted from dyes bound to the pump. At left, the pump is open towards the interior of the cell and has bound calcium ions and absorbed the ATP molecule – in other words, it is ‘charged’. The next step is the new, key result: in the red field, the pump is in the previously unknown closed state, where it has enclosed the ions to be sent out of the cell. The final stage illustrated shows that the pump has opened and released calcium ions into the surroundings. From here, it cannot return to the highlighted state. (Illustration: Daniel Terry/Dyla)

2017.11.09 | Research

The end of ‘Pump Fiction’

Our cells are capable of moving energy and material around to the places where they are required, and ensuring that the body works properly. But how do the cells do this in real time from the perspective of the individual molecule? A Danish research team has succeeded in revealing basic insights into this previously unknown world by carrying out…

2017.10.11 | Research

Molecular Velcro helps to assemble functional nuclear pore complexes

An international research team now explains how one of the largest molecular machineries - the nuclear pore complex – is being assembled using natively unfolded FG-repeats as molecular Velcro.

2017.10.12 | Research

Why do physicists blur their images before showing them to biologists?

How can cartoon images aid in understanding bacterial biological processes? How did Hollywood contribute to quantum physics? How do aesthetics, art, and design influence scientific visualization and vice versa? These are just some of the questions that a new book raises. Bjørn Panyella Pedersen, Ebbe Sloth Andersen and Ditte Høyer Engholm from…

2017.10.02 | Research

Llama-derived nanobodies as a new tool in solving crystal structure

Aarhus University scientists have developed miniature antibodies (nanobodies) that can be labelled on certain amino acids. This provides a direct route for solving new X-ray crystal structures of protein complexes important for gaining mechanistic understanding of cellular processes, which is important in the development of drugs.

Elevated levels of the bad LDL cholesterol increases the risk of premature death from a blood clot in the heart, so there is a great need for medicine which helps the body to remove it from the blood.

2017.09.26 | Research

Danish discovery can pave the way for more effective cholesterol medicine

Research from Aarhus University sheds new light on how the body converts the bad kind of cholesterol. The discovery could lead to new and potentially more effective medicine.

The researchers used  two populations of Holstein cows from Nordic countries and China and have identified several genetic variants associated with the fertility of the cows. Photo: Colourbox.

2017.09.12 | Research

Improved solution to increase fertility in high-yielding cows

Through decades, researchers have been able to increase milk production in cows by intense genetic selection. However, this has resulted in a reversal of the fertility of the cows. This has led the researchers to find an optimum solution.

2017.09.11 | Research

Chromosomal deletion catalogue in dairy cattle facilitates the identification of lethal mutations

Genetic mutations are responsible for a substantial yearly-economic loss in the dairy industry. Mapping of such variants is essential for effective breeding planning and performance improvement.

Peter Aasted Paulsen. Photo: Lisbeth Heilesen.

2017.09.04 | Grant

Peter Aasted Paulsen receives a donation at a ceremony in Copenhagen to study T-cell virus complex

On Friday, Peter Aasted Paulsen received a donation of DKK 100,000 at a ceremony at Rigshospitalet from Savværkejer Jeppe Juhl og Hustru Ovita Juhls Mindelegat to study sugar transport and their complexes.

Ditlev E. Brodersen. Photo: Tamo Meijburg.

2017.08.28 | Awards

Ditlev E. Brodersen receives ST Education Award

The ST Education Award 2017 goes to Associate Professor Ditlev Egeskov Brodersen for his contribution to increasing the quality of teaching at ST, not only through his own engaging teaching style, but also for developing a new tool that is available to all teachers.

Mogens Sandø Lund. Photo: Tamo Meijburg.

2017.08.28 | Awards, Knowledge exchange

Mogens Sandø Lund receives ST Industrial Collaboration Award

The ST Industrial Collaboration Award 2017 goes to Professor Mogens Sandø Lund, Department of Molecular Biology and Genetics, for his long-standing efforts and considerable influence on business collaboration regarding refinement and breeding in Denmark.

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