Peer-reviewed articles

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Latest peer-reviewed publications at MBG

Juhl, A. D., Sprenger, R. R., Modzel, M., Halder, S., Szomek, M., Akkerman, V., Xu, Y., Heegaard, C. W., Ejsing, C. S., Covey, D. F. & Wüstner, D. (2026). Live-Cell Imaging and Lipidomics of Low-Density Lipoprotein Containing Intrinsically Fluorescent Cholesteryl Esters. Analytical Chemistry, 98(9), 7069-7083. https://doi.org/10.1021/acs.analchem.5c05064

Neis, K., Civit Pitarch, L., Pedersen, K., Schachtner, M., Wengel, J., Wagner, R., Thiel, S., Kjems, J. & Valero Moreno, J. (2026). Lock, Protect, and Bind: In Vitro Selection of Locked Nucleic Acid-Modified Aptamers Using a Mutant T7 RNA Polymerase. Small Structures, 7(3), Article e202500677. https://doi.org/10.1002/sstr.202500677

Obsessive-Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, Anxiety Disorders Working Group of the Psychiatric Genomics Consortium, Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group of the Psychiatric Genomics Consortium, Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Nicotine Dependence GenOmics (iNDiGO) Consortium, Brikell, I., Grove, J., Sonuga-Barke, E., Hübel, C., Larsen, J. T. & Petersen, L. V. (2026). Mapping the genetic landscape across 14 psychiatric disorders. Nature, 649(8096), 406-415. https://doi.org/10.1038/s41586-025-09820-3

Bergman, J., Bakarić, R. & Brčić-Kostić, K. (2026). Measures of gene indispensability reveal the parallelism between phylogeny and ontogeny. BioSystems, 261, Article 105710. https://doi.org/10.1016/j.biosystems.2026.105710

Vind, A. C., Martínez, J. F., Wu, Z., Bugai, A., Mordente, K., Abis, G., Chamois, S., Ramalho, S., Pechincha, C., Ryder, L., Chen, Q., Rasmussen, M., Shi, X., He, D., Svejstrup, J. Q., Haahr, P., Gatfield, D., Conte, M. R., Jensen, T. H. ... Bekker-Jensen, S. (2026). Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes. Molecular Cell, 86(12), 2341-2357.e10. https://doi.org/10.1016/j.molcel.2026.04.034

Adam, L., Molenkamp, W. H., Nowak, J. S., Farzadfard, A., Gaarthuis, K., Kumar, R., Nielsen, J., Otzen, D. E., Johansson, J. & Abelein, A. (2026). Mechanism-selective inhibition of α-synuclein aggregation by the chaperone-like BRICHOS domain. The Journal of Biological Chemistry, 302(6), 113117. Article 113117. https://doi.org/10.1016/j.jbc.2026.113117

Hoetzel, J., Walbrun, A., Schäfer, M., Wang, T., Jørgensen, A. G., Becker, O., Stamatakis, K., Gunawan, V., Reichardt, L., Boettger, L., Bruckhoff, R. W., Kjems, J., Wachtveitl, J., Rief, M. & Suess, B. (2026). Mechanism underlying the high regulatory performance of the doxycycline riboswitch G12. Nature Communications, 17(1), Article 7697. https://doi.org/10.1038/s41467-026-76256-2

Laursen, M. J., Roth, M., Nissen, P., Stock, C. & Dieudonné, T. (2026). Mechanistic Insights into Autoinhibition of the Human Flippase ATP8B1. Journal of Membrane Biology, 259(1), Article 26. https://doi.org/10.1007/s00232-026-00391-6

Bugai, A., Hohmann, U., Lorenzo, A., Graf, M., Fin, L., Rouvière, J. O., Tirian, L., Dou, Y., Le Rest, M., Polák, P., Johnsen, D., Jakobsen, L., Andersen, J. S., Brennecke, J., Plaschka, C. & Jensen, T. H. (2026). Molecular basis of polyadenylated RNA fate determination in the nucleus. Nature, 655(8124), 1070-1078. https://doi.org/10.1038/s41586-026-10650-0

Vasilevsky, N. A., Toro, S., Matentzoglu, N., Flack, J. E., Mullen, K. R., Hegde, H., Gehrke, S., Whetzel, P. L., Shwetar, Y., Harris, N. L., Ngu, M. S., Alyea, G. L., Kane, M. S., Roncaglia, P., Sid, E., Thaxton, C. L., Wood, V., Abraham, R. S., Achatz, M. I. ... Haendel, M. A. (2026). Mondo: integrating disease terminology across communities. Genetics, 232(4), Article iyaf215. https://doi.org/10.1093/genetics/iyaf215

Gobira, P. H., Bastos, S., Rossi, R., Vægter, C. B., Chen, F., da Silva, N. R., Müller, H. K., Joca, S., Boesen, T., Viola, T. W., Yan, Y., Larsen, M. R., Carregar, V. C. & Grassi-Oliveira, R. (2026). Morphine reprograms brain-derived extracellular vesicle cargo associated with synaptic remodeling in the prefrontal cortex. Neurobiology of Disease, 227, Article 107501. https://doi.org/10.1016/j.nbd.2026.107501

da Fonseca Junior, A. M., Ispada, J., de Lima , C. B., Trabuco do Amaral, D., Juan Ross, P., Kadarmideen, H. & Pecora Milazzoto, M. (2026). Multiomics integration uncovers metabolic control of H3K27ac in bovine inner cell masses. Biology of Reproduction, 115(2), 369–378. https://doi.org/10.1093/biolre/ioaf244

Belapurkar, V., Malle, M. G., Kjems, J. & Sun, C. (2026). Multiplexed molecular imaging for spatial transcriptomics and proteomics. Current Opinion in Chemical Biology, 95, Article 102769. https://doi.org/10.1016/j.cbpa.2026.102769

Goleva, S. B., Leu, C., Anne Feng, Y. C., Burstein, D., Venkatesh, S., Birnbaum, R., Rajagopal, V. M., Straub, P., Christensen, J., Bautista, J. F., Busch, R. M., Najm, I. M., Grove, J., Børglum, A. D., Voloudakis, G., Roussos, P., Smoller, J., Lal, D. & Davis, L. K. (2026). Multisite, Multiancestry Genome-Wide Association Study Meta-Analysis of Functional Seizure Disorder in a Hospital Sample of 675,680 Patients. Biological Psychiatry Global Open Science, 6(1), Article 100604. https://doi.org/10.1016/j.bpsgos.2025.100604

Hejlesen, R., Bakkeren, C., Damsgaard, C., Laursen, L. S., Kjær-Sørensen, K., Corti, P., Malte, H., Oxvig, C. & Fago, A. (2026). Myoglobin Affects Tissue-Specific Transcriptome, Heart Regeneration and Whole Animal Metabolic Rates. The FASEB Journal, 40(1), Article e71424. https://doi.org/10.1096/fj.202503482RR

Aagaard, J. B., Gandini, R., Ballegaard, A.-S. R., Krogstrup Jensen, B., Dorn, B., Verner, A., Lenstrup, A., Sønderholm, M., Miehe, M., Pfützner, W., Jakob, T., Andersen, G. R., Möbs, C. & Spillner, E. (2026). Nanobody-based IgG simultaneously inhibit the allergenic and enzymatic activity of the dominant honeybee venom allergen. Nature Communications, 17(1), Article 1814. https://doi.org/10.1038/s41467-026-69572-0

Otzen, D. E., Gamon, L. F., Hägglund, P., Nielsen, J., Pedersen, J. N., Nybo, T., Nowak, J. S., Amstrup, S. K., Pirhaghi, M. & Davies, M. J. (2026). Nitrated products formed on α-synuclein are preferentially incorporated into oligomers but excluded from fibrils: A mechanism for accumulation of neurotoxic species. Biochimica et Biophysica Acta - Proteins and Proteomics, 1874(2), Article 141118. https://doi.org/10.1016/j.bbapap.2025.141118

Kofod Petersen, A., Bindslev, D. A., Forgie, A., Villesen, P. & Staun Larsen, L. (2026). Objective comparison of 3D dental scans in forensic odontology identification. Forensic Imaging, 44, Article 200672. https://doi.org/10.1016/j.fri.2026.200672

Valia Madapally, H., Hussein, A., Eriksen, M. W., Pedersen, B. P., Stokes, D. L. & Khandelia, H. (2026). On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC. The Journal of general physiology, 158(1). https://doi.org/10.1085/jgp.202513794

Talay, A., Belikov, A. V., To, P. K. P., Alfatemi, H. H., Alon, U., Deelen, J., Ewald, C. Y., Gems, D., Gorbunova, V., Gruber, J., Hägg, S., Hemming, J., Horvath, S., Kaya, A., Lewis, C. J., Maier, A. B., Marinova, M. B., Pawelec, G., Peleg, S. ... de Magalhães, J. P. (2026). Open problems in ageing science: a roadmap for biogerontology. GeroScience, 48(3), 3351-3360. https://doi.org/10.1007/s11357-025-01964-4

Blotenburg, M., Esin, B., Buddharaju, S. & Zeller, P. (2026). Optimization of Gastruloid Pre-culture Conditions for Reproducible Germ Layer Composition. In V. Pasque & K. Turksen (Eds.), Stem Cell-Based Human Embryo Models: Methods and Protocols (pp. 305-319). Humana Press. https://doi.org/10.1007/7651_2025_667

Madsen, P. N., Jørgensen, P. B., Clausen, M. V. & Knudsen, C. R. (2026). Optimized purification workflow for advanced eEF1A studies: Impact of His-tagging on stability, functionality, and yield. Analytical Biochemistry, 710, Article 116017. https://doi.org/10.1016/j.ab.2025.116017

Song, P., Su, J., Kristine Vraa, C. L., Gockert, M., Fjelstrup, S., Hager, H. & Kjems, J. (2026). Optimizing C14120-based LNPs for in vitro and in vivo mRNA delivery. Molecular Therapy Nucleic Acids, 37(1), Article 102866. https://doi.org/10.1016/j.omtn.2026.102866

Lyngsø, N. M. & Otzen, D. E. (2026). Optimizing phage elution for biopanning of plastic materials. Biochemical and Biophysical Research Communications, 829, 154187. Article 154187. https://doi.org/10.1016/j.bbrc.2026.154187

Garg, A., Brasnett, C., Marrink, S. J., Koren, K. & Kjaergaard, M. (2026). Oxygen depletion in biomolecular condensates is dominated by macromolecular density. Nature Communications, 17(1), Article 2603. https://doi.org/10.1038/s41467-026-69376-2

Groslambert, J., Buch-Larsen, S. C., Hendriks, I. A., Kurzbauer, R., Elsborg, J. D., Chatrin, C., Agnew, T., Henfrey, C., Tellier, M., Prokhorova, E., Hoang, S. M., Barosso-Gonzalez, J., O’Sullivan, R. J., Clausen, T., Nielsen, M. L. & Ahel, I. (2026). PARG regulates the proteasomal degradation of TARG1. Cell Reports, 45(1), Article 116789. https://doi.org/10.1016/j.celrep.2025.116789

Authier, F., Jan, A., Faress, I., Skoven, C. S., Esperon-Abril, I., Tharmakulasingam Balasubramaniam, S., Coquelin, K.-S., Nyengaard, J. R., Scavenius, C., Attianese, B., Sevillano-Quispe, O. G., Eskildsen, S. F., Thomsen, J. S., Hansen, B. & van Aalten, D. MF. (2026). Pathogenic O-GlcNAc dyshomeostasis is associated with cortical malformations and hyperactivity. eLife. Advance online publication. https://doi.org/10.7554/elife.107170.2

Rui, Y., Zaoralová, M., Dwyer, W. P., Reyes, A. V., Grismer, T. S., Abel, N. B., Jayachandran, D., Chundawat, S. P. S., Ott, T., Kieber, J. J., Dahlberg, P. D., Xu, S. L. & Dinneny, J. R. (2026). Plant cell wall-plasma membrane attachments mediate stress resilience through cellulose synthase complexes and remorins. Cell, 189(16), 5115-5134.e8. https://doi.org/10.1016/j.cell.2026.05.009

Wang, X., Aninta, S. G., Garcia-Erill, G., Li, Z., Khan, A., Liu, X., Bertola, L. D., Dharmayanthi, A. B., Yulianto, Yonathan, Rossi, C., Cauble-Sims, R., Rosen, B. D., Hagen, D. E., Heaton, M. P., Smith, T. P. L., Lenstra, J. A., Martins, N. F. G., Sinding, M. H. S. ... Heller, R. (2026). Population structure and domestication history of the Javan banteng. Current Biology, 36(2), 458-473.e8. https://doi.org/10.1016/j.cub.2025.11.076

Mouritzen, T. W., Bornhofen, E., Jayakody, T., Skovbjerg, C. K., Kærgaard Nielsen, L., Schiemann, A., Knudsen, J. C. N., Füchtbauer, W. S., Orabi, J., Janss, L. & Andersen, S. U. (2026). Post-hoc permutation GWAS refinement reveals robust marker-trait associations in faba bean. Frontiers in Plant Science, 17, 1-14. Article 1895808. https://doi.org/10.3389/fpls.2026.1895808

Jensen, B. B., Krogh, M. A., Pastell, M., Spiliotopoulou, A., Nielsen, K. V., Thorup, V. M., Foldager, L., Fred, H., Oliveira, V. H. S. D., Frandsen, M., E. G. Bertelsen, M. & Petersen, P. (2026). Precision Fish Farming in land-based recirculating aquaculture systems – State of the art and future perspectives: White Paper. Norwegian Veterinary Institute . https://www.vetinst.no/rapporter-og-publikasjoner/rapporter/2026/precision-fish-farming-i-ras/_/attachment/inline/e7b60cd9-e88b-4d63-a52d-f3cb1ff8262e:68c3d02a0d878b1857b4e9bcc9298a12161f88be/2026_12_IntelliRAS%20White%20paper%20KOMPLETT.pdf

Şen, A., Karaman, E., Heegaard, C. W., Poulsen, N. A. & Buitenhuis, A. J. (2026). Predicting riboflavin (vitamin B₂) and cobalamin (vitamin B₁₂) concentrations in Danish cow milk using Fourier transform mid infrared spectra. International Dairy Journal, 179, Article 106656. https://doi.org/10.1016/j.idairyj.2026.106656

Coutant, M. P., Foldager, L., Pedersen, L. J., Larsen, M. L. V. & Kaiser, M. (2026). Prepartum postural patterns and farrowing outcomes in sows with and without postpartum dysgalactia syndrome in crated and loose housing systems. Applied Animal Behaviour Science, 304, 1-7. Article 107123. https://doi.org/10.1016/j.applanim.2026.107123

Gierlich, S. A., Jayakody, T. B., Augustine, S. M., Liu, H., Jääskeläinen, M., Vaisalu, T., Snowdon, R. J. & Andersen, S. U. (2026). Progress and Challenges in Faba Bean Genetic Engineering. Legume Science, 8(2), Article e70123. https://doi.org/10.1002/leg3.70123

Cho, H., Nielsen, M. L. & Olsen, J. V. (2026). Quantitative proteomics and phosphoproteomics reveal glucocorticoid stimulation of TLR and Rho GTPase signaling in neutrophil-like cells. Genome Biology, 27(1), Article 77. https://doi.org/10.1186/s13059-026-03985-4

Nielsen, S. B. & Otzen, D. E. (2026). Quartz Crystal Microbalances as Tools for Probing Protein-Membrane Interactions. In Lipid-Protein Interactions: Methods and Protocols (Vol. 3001, pp. 35-56) https://doi.org/10.1007/978-1-0716-5054-7_2

Demontis, D., Duan, J., Hsu, Y.-H. H., Pintacuda, G., Grove, J., Nielsen, T. T., Thirstrup, J., Martorana, M., Botts, T., Satterstrom, F. K., Bybjerg-Grauholm, J., Tsai, J. H. Y., Glerup, S., Hoogman, M., Buitelaar, J., Klein, M., Ziegler, G. C., Jacob, C., Grimm, O. ... Børglum, A. D. (2026). Rare genetic variants confer a high risk of ADHD and implicate neuronal biology. Nature, 649(8098), 909-917. https://doi.org/10.1038/s41586-025-09702-8

Riedelbauch, S., Masser, S., Fasching, S., Lin, S. Y., Salgania, H. K., Aarup, M., Ebert, A., Jeske, M., Levine, M. T., Stelzl, U. & Andersen, P. (2026). Recurrent innovation of protein-protein interactions in the Drosophila piRNA pathway. EMBO Journal, 45(6), 1909-1932. Article 98. https://doi.org/10.1038/s44318-025-00439-8

Kortenoeven, M. L. A., Bogdanovic, M., Appel, I., Skjødt, K., Fuchtbauer, E. M., Madsen, K., Lund, L., Chambrey, R., Eladari, D., Alexander, R. T., Hübner, C. A., Hennings, J. C. & Dimke, H. (2026). Reduced Expression of Magnesium Transport Proteins in the Distal Convoluted Tubule of Clcnkb-Deficient Mice May Explain Urinary Magnesium Wasting in Classical Bartter Syndrome. Acta Physiologica, 242(9), Article e70295. https://doi.org/10.1111/apha.70295

TRACERx Consortium & CAPTURE Consortium (2026). Retraction Note: Antibodies against endogenous retroviruses promote lung cancer immunotherapy. Nature, 649, Article 1330. https://doi.org/10.1038/s41586-026-10104-7

Fischer, C. M., Edu, I. A., Šneideris, T., Baronaite, I., Toprakcioglu, Z., Deck, L.-T., Qian, D., Scrutton, R., Dreyer, L., Wen, J., Otzen, D. E., Wu, S., Perrett, S. & Knowles, T. P. J. (2026). Reversibility and β-sheet formation are decoupled in tau condensate aging. Proceedings of the National Academy of Sciences of the United States of America, 123(11), Article e2522993123. https://doi.org/10.1073/pnas.2522993123