Peña Díaz, S., Zhang, Z., Jiang, Y., Daugberg, A. O. H.
, López Hernández, M., Nielsen, J., Dueholm, M. K. D.
, Dong, MD., Pedersen, J. S., Otzen, D. E. & Wang, H. (2025).
Natural Design of a Stabilized Cross-β Fold: Structure of the FuA FapC from Pseudomonas Sp. UK4 Reveals a Critical Role for Stacking of Imperfect Repeats.
Advanced Materials,
37(34), Article 2505503.
https://doi.org/10.1002/adma.202505503
Subrahmaniam, H. J., Pico, X.
, Bataillon, T., Salomonsen, C. L., Glasius, M. & Ehlers, B. (2025).
Natural variation in root exudate composition in the genetically structured Arabidopsis thaliana in the Iberian Peninsula.
New Phytologist,
245(4), 1437-1449.
https://doi.org/10.1111/nph.20314
Bryzek, D., Gasiorek, A., Kowalczyk, D., Santocki, M., Ciaston, I., Dobosz, E., Kolaczkowska, E.
, Kjøge, K., Kantyka, T., Lech, M., Potempa, B.
, Enghild, J. J., Potempa, J. & Koziel, J. (2025).
Non-classical neutrophil extracellular traps induced by PAR2-signaling proteases.
Cell Death & Disease,
16(1), Article 109.
https://doi.org/10.1038/s41419-025-07428-z
Andersen-Civil, A. I. S., Mantel, M., Soh, J., Mostowy, S., Brugman, S.
& Vanwalleghem, G. C. (2025).
Novel and unscrutinized immune entities of the zebrafish gut.
FEBS Letters,
599(23), 3444-3455.
https://doi.org/10.1002/1873-3468.70161
Mitchell, C. W., Yuan, H., Sønderstrup-Jensen, M., Ferenbach, A. T. & van Aalten, D. M. F. (2025).
O-GlcNAcylation of the intellectual disability protein DDX3X exerts proteostatic cell cycle control.
Open Biology,
15(7), Article 250064.
https://doi.org/10.1098/rsob.250064
Talay, A., Belikov, A. V., To, P. K. P., Alfatemi, H. H., Alon, U., Deelen, J., Ewald, C. Y., Gems, D., Gorbunova, V., Gruber, J., Hägg, S., Hemming, J., Horvath, S., Kaya, A., Lewis, C. J., Maier, A. B., Marinova, M. B., Pawelec, G., Peleg, S. ... de Magalhães, J. P. (2025).
Open problems in ageing science: a roadmap for biogerontology.
GeroScience. Advance online publication.
https://doi.org/10.1007/s11357-025-01964-4
Broksø, A. D., Bendixen, L., Fammé, S., Mikkelsen, K., Jensen, T. I. & Bak, R. O. (2025).
Orthogonal transcriptional modulation and gene editing using multiple CRISPR/Cas systems.
Molecular Therapy,
33(1), 71-89.
https://doi.org/10.1016/j.ymthe.2024.11.024
Mishra, A., Golbek, T. W., Thomassen, A. B., Zuzic, L., Schmüser, L., Saeed, K. H., Madzharova, F., Nielsen, J., Schiøtt, B., Otzen, D. E. & Weidner, T. (2025).
Pathological Folding of α-Synuclein on Polystyrene Nanoplastic Revealed by Sum Frequency Scattering and 2D Infrared Spectroscopy.
The Journal of Physical Chemistry Letters,
16(45), 11893-11900.
https://doi.org/10.1021/acs.jpclett.5c02526
Waligórska, I., Żak, K. M., Mikrut, N., Budziaszek, J., Medviediev, V., Bielecka, E., Kantyka, T., Kozieł, J.
, Thøgersen, I. B., Enghild, J. J., Grudnik, P., Potempa, J. & Książek, M. (2025).
Periodontopathogens degrade angiotensin I from the human renin-angiotensin system through surface-attached proteases.
Scientific Reports,
15(1), Article 43309.
https://doi.org/10.1038/s41598-025-27891-0
Schlosser, A., Pilecki, B., Allen, C., Benest, A. V., Lynch, A. P., Hua, J., Ved, N., Blackley, Z., Andersen, T. L., Hennig, D., Graversen, J. H., Möller, S., Skallerup, S., Ormhøj, M., Lange, C., Agostini, H. T., Grauslund, J., Heegaard, S., Dacheva, I. ... Sorensen, G. L. (2025).
Pharmacological blocking of microfibrillar-associated protein 4 reduces retinal neoangiogenesis and vascular leakage.
Molecular Therapy,
33(3), 1048-1072.
https://doi.org/10.1016/j.ymthe.2025.01.038
Jansen, S. A. H.
, Dreyer, L. S. A., van Basten, J., Yao, Y.
, Otzen, D. E., de Greef, T. F. A., Knowles, T. P. J., Meijer, E. W. & Erkamp, N. A. (2025).
PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning.
ACS Nano,
19(45), 38981-38989.
https://doi.org/10.1021/acsnano.5c07268
Zhang, X.
, Grove, J., Gu, Y.
, Buus, C. K., Nielsen, L. K., Neufeld, S. A. S., Koko, M., Malawsky, D. S., Wade, E. M., Verhoef, E., Gui, A., Hegemann, L., Geschwind, D. H., Wray, N. R., Havdahl, A., Ronald, A., St Pourcain, B., Robinson, E. B., Bourgeron, T. ... APEX consortium (2025).
Polygenic and developmental profiles of autism differ by age at diagnosis.
Nature,
646(8087), 1146-1155.
https://doi.org/10.1038/s41586-025-09542-6
Smit, R. A. J., Wade, K. H., Hui, Q., Arias, J. D., Yin, X., Christiansen, M. R., Yengo, L., Preuss, M. H., Nakabuye, M., Rocheleau, G., Graham, S. E., Buchanan, V. L., Chittoor, G., Graff, M., Guindo-Martínez, M., Lu, Y., Marouli, E., Sakaue, S., Spracklen, C. N. ... VA Million Veteran Program (2025).
Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Nature Medicine,
31(9), 3151-3168.
https://doi.org/10.1038/s41591-025-03827-z
Henches, L., Kim, J., Yang, Z., Rubinacci, S., Pires, G.
, Albiñana, C., Boetto, C., Julienne, H., Frouin, A., Auvergne, A., Suzuki, Y., Djebali, S., Delaneau, O., Ganna, A.
, Vilhjálmsson, B., Privé, F. & Aschard, H. (2025).
Polygenic risk score prediction accuracy convergence.
Human Genetics and Genomics Advances,
6(3), Article 100457.
https://doi.org/10.1016/j.xhgg.2025.100457
Mishra, A., Golbek, T. W., Zubia-Aranburu, J., Madzharova, F., Drace, T., Bøggild, A., Boesen, T., Saeed, K. H., Klausen, L. H., Dong, M., Roeters, S. J. & Weidner, T. (2025).
Polystyrene Nanoplastic Contaminants Denature Human Apolipoprotein A-1.
Nano Letters,
25(35), 13160-13165.
https://doi.org/10.1021/acs.nanolett.5c02743
Wimberley, T., Plana-Ripoll, O., Pedersen, C. B., Pedersen, M. G., Dreier, J. W., Christensen, J., Horsdal, H. T., Astrup, A., Thompson, W. K., Helenius, D.
, McGrath, J. J., Wray, N. R., Petersen, L. V., Vilhjálmsson, B., Mortensen, P. B. & Agerbo, E. (2025).
Population-representative inference for primary and secondary outcomes in extended case-cohort designs.
Discover public health,
22(1), Article 599.
https://doi.org/10.1186/s12982-025-00888-w
Martín-Rivada, Á., Martos-Moreno, G., Guerra-Cantera, S., Campillo-Calatayud, A.
, Oxvig, C., Frystyk, J., Chowen, J. A., Barrios, V. & Argente, J. (2025).
Prepubertal Children With Obesity Have High Free IGF-1 Levels and Accelerated Growth Despite Reduced Pappalysin Levels.
Journal of Clinical Endocrinology and Metabolism,
110(3), e622-e629.
https://doi.org/10.1210/clinem/dgae288
Kawamura, Y. K., Ozonov, E. A., Papasaikas, P., Kondo, T., Nguyen, N. V., Stadler, M. B., Smallwood, S. A., Koseki, H. & Peters, A. H. F. M. (2025).
Preventing CpG hypermethylation in oocytes safeguards mouse development.
Developmental Cell,
60(23), 3285-3303.e9.
https://doi.org/10.1016/j.devcel.2025.08.005
Ismail, S., Kubíková, J., Maichel, M.
, Andersen, P. & Jeske, M. (2025).
Probing direct interactions between nuclear proteins in cells with nxReLo.
Proceedings of the National Academy of Sciences of the United States of America,
122(48), Article e2518711122.
https://doi.org/10.1073/pnas.2518711122
Mohora, I., Patiño Guillén, G.
, Neis, K., Valero, J., Keyser, U. F. & Bošković, F. (2025).
Programmable RNA Nanostructures Enable Nanopore Detection of Cotranscriptionally Introduced RNA Modifications.
Nano Letters,
25(32), 12184-12192.
https://doi.org/10.1021/acs.nanolett.5c02391
Biswas, D., Liu, Y. H., Herrero, J., Wu, Y., Moore, D. A., Karasaki, T., Grigoriadis, K., Lu, W. T., Veeriah, S., Naceur-Lombardelli, C., Magno, N., Ward, S., Frankell, A. M., Hill, M. S., Colliver, E., de Carné Trécesson, S., East, P., Malhi, A., Snell, D. M. ... TRACERx Consortium (2025).
Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma.
Nature Cancer,
6(1), 86-101. Article 10110.
https://doi.org/10.1038/s43018-024-00883-1
Fabbrizio, P., Baindoor, S., Margotta, C.
, Su, J., Morrissey, E. P., Woods, I., Hogg, M. C., Vianello, S., Venø, M. T.
, Kjems, J., Sorarù, G., Bendotti, C., Prehn, J. H. M. & Nardo, G. (2025).
Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications.
Brain Pathology,
35(4), Article e13328.
https://doi.org/10.1111/bpa.13328
Demir, F., Kovalenko, E., Lassé, M.
, Svenningsen, E. B., Bernth Jensen, J. M., Billing, A. M., Groeneveld, K., Hutzfeldt, A., Nilges, L.
, Guerra, J. P. L., Pietrzak-Lichwa, K. J., Tan, Y., Colby, E., Hansen, A. G.
, Kurmasheva, N., Olagnier, D., Choi, D., Richter, M. M., Laufer, S. D.
... Rinschen, M. M. (2025).
Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment.
The EMBO Journal,
44(24), 7721-7758.
https://doi.org/10.1038/s44318-025-00598-8
Nowak, J. S., Kruuse, N., Rasmussen, H. Ø., Tian, P.
, Astono, J., Schultz-Nielsen, S.
, Thøgersen, M. S., Stougaard, P., Pedersen, J. S. & Otzen, D. E. (2025).
Quaternary stabilization of a GH2 β-galactosidase from the psychrophile A. ikkensis, a flexible and unstable dimeric enzyme.
Protein Science,
34(5), Article e70141.
https://doi.org/10.1002/pro.70141
Demontis, D., Duan, J., Hsu, Y.-H. H., Pintacuda, G.
, Grove, J., Nielsen, T. T., Thirstrup, J., Martorana, M., Botts, T., Satterstrom, F. K., Bybjerg-Grauholm, J.
, Tsai, J. H. Y., Glerup, S., Hoogman, M., Buitelaar, J., Klein, M., Ziegler, G. C., Jacob, C., Grimm, O.
... Børglum, A. D. (2025).
Rare genetic variants confer a high risk of ADHD and implicate neuronal biology.
Nature. Advance online publication.
https://doi.org/10.1038/s41586-025-09702-8
Zhang, C., Reid, K.
, Schierup, M. H., Wang, H., Candolin, U. & Merilä, J. (2025).
Rate of de novo mutations in the three-spined stickleback.
Heredity,
134(7), 387-395.
https://doi.org/10.1038/s41437-025-00767-9
Riedelbauch, S., Masser, S., Fasching, S., Lin, S. Y., Salgania, H. K.
, Aarup, M., Ebert, A., Jeske, M., Levine, M. T., Stelzl, U.
& Andersen, P. (2025).
Recurrent innovation of protein-protein interactions in the Drosophila piRNA pathway.
EMBO Journal, Article 98. Advance online publication.
https://doi.org/10.1038/s44318-025-00439-8
Golan, N., Parizat, A., Tabachnikov, O., Barnea, E., Olsen, W. P.
, Otzen, D. E. & Landau, M. (2025).
Resilience and Charge-Dependent Fibrillation of functional amyloid: Interactions of Pseudomonas Biofilm-Associated FapB and FapC Amyloids.
The Journal of Biological Chemistry,
301(2), Article 108096.
https://doi.org/10.1016/j.jbc.2024.108096
Kefalopoulou, S., Rullens, P. M. J., de Luca, K. L., de Vries, S. S., Korthout, T., van Oudenaarden, A.
, Zeller, P. & Kind, J. (2025).
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation.
Nature Cell Biology,
27(7), 1186-1198.
https://doi.org/10.1038/s41556-025-01687-w
Gobet, A., Moissonnier, L., Zarkadas, E., Magnard, S., Bettler, E.
, Martin, J., Terreux, R., Schoehn, G., Orelle, C., Jault, J. M., Falson, P. & Chaptal, V. (2025).
Rhodamine6G and Hœchst33342 narrow BmrA conformational spectrum for a more efficient use of ATP.
Nature Communications,
16(1), Article 1745.
https://doi.org/10.1038/s41467-025-56849-z
Nowak, J. S., Olesen, S., Tian, P.
, Bærentsen, R. L., Brodersen, D. E. & Otzen, D. E. (2025).
Role of electrostatics in cold adaptation: A comparative study of eury- and stenopsychrophilic triose phosphate isomerase.
Biochimica et Biophysica Acta - Proteins and Proteomics,
1873(4), Article 141072.
https://doi.org/10.1016/j.bbapap.2025.141072
Kristoffersen, E. L., McRae, E. K. S., Sørensen, N. R., Holliger, P.
& Andersen, E. S. (2025).
Roles of dimeric intermediates in RNA-catalyzed rolling circle synthesis.
Nucleic Acids Research,
53(11), Article gkaf057.
https://doi.org/10.1093/nar/gkaf057
Pinheiro, F., Nowak, J. S., Zueva, E.
, Pheasant, E. C., Grene, I. K., Lampinen, V. & Kjaergaard, M. (2025).
Screening de novo designed protein binders in unpurified lysate using flow induced dispersion analysis.
Protein Science,
34(10), Article e70286.
https://doi.org/10.1002/pro.70286
Stenberg, K., Korhonen, S., Seemab, U.
, Dupont, D. M., Kjems, J., Honkakoski, P. & Subrizi, A. (2025).
Selection of locally administered ocular tissue-targeting RNA aptamers using in vivo SELEX.
European Journal of Pharmaceutical Sciences,
212, Article 107217.
https://doi.org/10.1016/j.ejps.2025.107217
Baindoor, S., Gibriel, H. A. Y., Kool, L.
, Su, J., Demaegd, K. C., Venø, M. T., Van Den Berg, L. H.
, Kjems, J., Van Es, M. A. & Prehn, J. H. M. (2025).
Serum small non-coding RNA define molecular subtypes in amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. Advance online publication.
https://doi.org/10.1080/21678421.2025.2574690
Hollingshead, S., McVicker, G.
, Nielsen, M. R., Zhang, Y., Pilla, G., Jones, R. A., Thomas, J. C.
, Johansen, S. E. H., Exley, R. M.
, Brodersen, D. E. & Tang, C. M. (2025).
Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system.
mBio,
16(2), e0261624.
https://doi.org/10.1128/mbio.02616-24
Bro̷chner, B. V., Zhang, X., Nielsen, J., Kjems, J., Otzen, D. E. & Malle, M. G. (2025).
Single-vesicle Tracking of α-Synuclein Oligomers Reveals Pore Formation by a Three-Stage Model.
ACS Nano,
19(36), 32108-32122.
https://doi.org/10.1021/acsnano.5c04005
Staehr, C., Login, H., Melnikova, E., Bakun, M., Ziemlinska, E.
, Kisiswa, L., Berenji Ardestani, S., Nolte, S. S., Beck, H. C.
, Hansen, L. M. B., Postnov, D., Verkhratsky, A., Malik, A. R.
, Nykjær, A. & Matchkov, V. (2025).
SorCS2 Is Important for Astrocytic Function in Neurovascular Signaling.
Acta Physiologica (Print),
241(6), Article e70052.
https://doi.org/10.1111/apha.70052
Blotenburg, M., Suurenbroek, L., Bax, D., de Visser, J., Bhardwaj, V., Braccioli, L., de Wit, E., van Boxtel, A., Marks, H.
& Zeller, P. (2025).
Stem cell culture conditions affect in vitro differentiation potential and mouse gastruloid formation.
PLoS One,
20(3), Article e0317309.
https://doi.org/10.1371/journal.pone.0317309
Zhang, B.-C., Pedersen, A., Reinert, L. S., Li, Y.
, Narita, R., Idorn, M., Hu, L., Skouboe, M. K., Li, S.
, Maimaitili, M., Ding, X., Cong, Y., Zhao, J., Frémond, M.-L.
, Mikkelsen, K., Gao, Z., Huang, J.-R.
, Thomsen, E. A., Mikkelsen, J. H. ... Paludan, S. R. (2025).
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor.
Nature Immunology,
26(11), 1916-1930.
https://doi.org/10.1038/s41590-025-02283-8
Nel, L., Thaysen, K., Jamecna, D.
, Olesen, E., Langer, J.
, Frain, K. M., Szomek, M., Höglinger, D., Wüstner, D.
& Pedersen, B. P. (2025).
Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related protein.
Life Science Alliance,
8(1), Article e202402990.
https://doi.org/10.26508/lsa.202402990
Rotilio, L., Bayer, T., Meinert, H., Teixeira, L. M. C., Johansen, M. B., Sommerfeldt, A., Petersen, A. R., Sandahl, A., Keller, M. B., Holck, J., Paiva, P.
, Otzen, D. E., Bornscheuer, U. T., Wei, R., Fernandes, P. A., Ramos, M. J., Westh, P. & Morth, J. P. (2025).
Structural and Functional Characterization of an Amidase Targeting a Polyurethane for Sustainable Recycling.
Angewandte Chemie International Edition,
64(7), Article e202419535.
https://doi.org/10.1002/anie.202419535