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Peer-reviewed publications at MBG - 2025

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Biswas, D., Liu, Y. H., Herrero, J., Wu, Y., Moore, D. A., Karasaki, T., Grigoriadis, K., Lu, W. T., Veeriah, S., Naceur-Lombardelli, C., Magno, N., Ward, S., Frankell, A. M., Hill, M. S., Colliver, E., de Carné Trécesson, S., East, P., Malhi, A., Snell, D. M. ... TRACERx Consortium (2025). Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma. Nature Cancer, 6(1), 86-101. Article 10110. https://doi.org/10.1038/s43018-024-00883-1
Fabbrizio, P., Baindoor, S., Margotta, C., Su, J., Morrissey, E. P., Woods, I., Hogg, M. C., Vianello, S., Venø, M. T., Kjems, J., Sorarù, G., Bendotti, C., Prehn, J. H. M. & Nardo, G. (2025). Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications. Brain Pathology, 35(4), Article e13328. https://doi.org/10.1111/bpa.13328
Demontis, D., Duan, J., Hsu, Y.-H. H., Pintacuda, G., Grove, J., Nielsen, T. T., Thirstrup, J., Martorana, M., Botts, T., Satterstrom, F. K., Bybjerg-Grauholm, J., Tsai, J. H. Y., Glerup, S., Hoogman, M., Buitelaar, J., Klein, M., Ziegler, G. C., Jacob, C., Grimm, O. ... Børglum, A. D. (2025). Rare genetic variants confer a high risk of ADHD and implicate neuronal biology. Nature. Advance online publication. https://doi.org/10.1038/s41586-025-09702-8
Zhang, C., Reid, K., Schierup, M. H., Wang, H., Candolin, U. & Merilä, J. (2025). Rate of de novo mutations in the three-spined stickleback. Heredity, 134(7), 387-395. https://doi.org/10.1038/s41437-025-00767-9
Riedelbauch, S., Masser, S., Fasching, S., Lin, S. Y., Salgania, H. K., Aarup, M., Ebert, A., Jeske, M., Levine, M. T., Stelzl, U. & Andersen, P. (2025). Recurrent innovation of protein-protein interactions in the Drosophila piRNA pathway. EMBO Journal, Article 98. Advance online publication. https://doi.org/10.1038/s44318-025-00439-8
Golan, N., Parizat, A., Tabachnikov, O., Barnea, E., Olsen, W. P., Otzen, D. E. & Landau, M. (2025). Resilience and Charge-Dependent Fibrillation of functional amyloid: Interactions of Pseudomonas Biofilm-Associated FapB and FapC Amyloids. The Journal of Biological Chemistry, 301(2), Article 108096. https://doi.org/10.1016/j.jbc.2024.108096
Kefalopoulou, S., Rullens, P. M. J., de Luca, K. L., de Vries, S. S., Korthout, T., van Oudenaarden, A., Zeller, P. & Kind, J. (2025). Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation. Nature Cell Biology, 27(7), 1186-1198. https://doi.org/10.1038/s41556-025-01687-w
Gobet, A., Moissonnier, L., Zarkadas, E., Magnard, S., Bettler, E., Martin, J., Terreux, R., Schoehn, G., Orelle, C., Jault, J. M., Falson, P. & Chaptal, V. (2025). Rhodamine6G and Hœchst33342 narrow BmrA conformational spectrum for a more efficient use of ATP. Nature Communications, 16(1), Article 1745. https://doi.org/10.1038/s41467-025-56849-z
Stenberg, K., Korhonen, S., Seemab, U., Dupont, D. M., Kjems, J., Honkakoski, P. & Subrizi, A. (2025). Selection of locally administered ocular tissue-targeting RNA aptamers using in vivo SELEX. European Journal of Pharmaceutical Sciences, 212, Article 107217. https://doi.org/10.1016/j.ejps.2025.107217
Baindoor, S., Gibriel, H. A. Y., Kool, L., Su, J., Demaegd, K. C., Venø, M. T., Van Den Berg, L. H., Kjems, J., Van Es, M. A. & Prehn, J. H. M. (2025). Serum small non-coding RNA define molecular subtypes in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. Advance online publication. https://doi.org/10.1080/21678421.2025.2574690
Hollingshead, S., McVicker, G., Nielsen, M. R., Zhang, Y., Pilla, G., Jones, R. A., Thomas, J. C., Johansen, S. E. H., Exley, R. M., Brodersen, D. E. & Tang, C. M. (2025). Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system. mBio, 16(2), e0261624. https://doi.org/10.1128/mbio.02616-24
Blotenburg, M., Suurenbroek, L., Bax, D., de Visser, J., Bhardwaj, V., Braccioli, L., de Wit, E., van Boxtel, A., Marks, H. & Zeller, P. (2025). Stem cell culture conditions affect in vitro differentiation potential and mouse gastruloid formation. PLoS One, 20(3), Article e0317309. https://doi.org/10.1371/journal.pone.0317309
Nel, L., Thaysen, K., Jamecna, D., Olesen, E., Langer, J., Frain, K. M., Szomek, M., Höglinger, D., Wüstner, D. & Pedersen, B. P. (2025). Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related protein. Life Science Alliance, 8(1), Article e202402990. https://doi.org/10.26508/lsa.202402990
Rotilio, L., Bayer, T., Meinert, H., Teixeira, L. M. C., Johansen, M. B., Sommerfeldt, A., Petersen, A. R., Sandahl, A., Keller, M. B., Holck, J., Paiva, P., Otzen, D. E., Bornscheuer, U. T., Wei, R., Fernandes, P. A., Ramos, M. J., Westh, P. & Morth, J. P. (2025). Structural and Functional Characterization of an Amidase Targeting a Polyurethane for Sustainable Recycling. Angewandte Chemie International Edition, 64(7), Article e202419535. https://doi.org/10.1002/anie.202419535
Dubiez, E., Garland, W., Finderup Brask, M., Boeri Erba, E., Heick Jensen, T., Kadlec, J. & Cusack, S. (2025). Structural basis for the synergistic assembly of the snRNA export complex. Nature Structural and Molecular Biology, 32(8), 1555-1566. https://doi.org/10.1038/s41594-025-01595-5
Thorsen, T. S., Kulkarni, Y., Sykes, D. A., Bøggild, A., Drace, T., Hompluem, P., Iliopoulos-Tsoutsouvas, C., Nikas, S. P., Daver, H., Makriyannis, A., Nissen, P., Gajhede, M., Veprintsev, D. B., Boesen, T., Kastrup, J. S. & Gloriam, D. E. (2025). Structural basis of THC analog activity at the Cannabinoid 1 receptor. Nature Communications, 16(1), Article 486. https://doi.org/10.1038/s41467-024-55808-4
Silale, A., Madej, M., Mikruta, K., Frey, A. M., Hart, A. J., Baslé, A., Scavenius, C., Enghild, J. J., Trost, M., Hirt, R. P. & van den Berg, B. (2025). Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota. Nature Microbiology, 10(11), 2845-2859. https://doi.org/10.1038/s41564-025-02132-2
Singh, P., Kadam, N. Y., Panigrahi, R., Mehrotra, A., Upadhayay, K., Dey, M., Tyagi, A., Aquib, M., Nielsen, J., Kleijwegt, G., Singh, P., Sharma, A., Rao, A., Otzen, D. E., Kumar, A. & Sharma, D. (2025). Sulfamerazine as a Potential Modulator against α-Synuclein Aggregation and Associated Toxicity. ACS Chemical Neuroscience, 16(5), 880-894. https://doi.org/10.1021/acschemneuro.4c00803
Zaheer, S., Baindoor, S., Connolly, N. M. C., Siebenbrodt, K., Bauer, S., Rosenow, F., Andersen, J. S., Venø, M. T., Kjems, J., Henshall, D. C. & Prehn, J. H. M. (2025). Temporal Dynamics of tsRNA Regulation Mark an Abrupt Transition After Epileptogenesis. Journal of Neurochemistry, 169(12), Article e70317. https://doi.org/10.1111/jnc.70317
McLain, A., Kowalczyk, A., Baran-Rachwalska, P., Sutera, F. M., Robertson, L. J., Nielsen, N. S., Enghild, J. J., Cobice, D., Bonelli, F., Barbaro, V., Ferrari, S., Patterson, B., Moore, L., Marshall, J., Nesbit, M. A. & Moore, T. (2025). TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery. Journal of Controlled Release, 382, Article 113681. https://doi.org/10.1016/j.jconrel.2025.113681
Malham, M., Vestergaard, M. V., Bataillon, T., Villesen, P., Dempfle, A., Bang, C., Engsbro, A. L., Jakobsen, C., Franke, A., Wewer, V., Thingholm, L. B. & Petersen, A. M. (2025). The Composition of the Fecal and Mucosa-adherent Microbiota Varies Based on Age and Disease Activity in Ulcerative Colitis. Inflammatory Bowel Diseases, 31(2), 501-513. https://doi.org/10.1093/ibd/izae179
Car, J., Ong, Q. C., Erlikh Fox, T., Leightley, D., Kemp, S. J., Švab, I., Tsoi, K. K. F., Sam, A. H., Kent, F. M., Hertelendy, A. J., Longhurst, C. A., Powell, J., Hamdy, H., Nguyen, H. V. Q., Aoun Bahous, S., Wang, M., Baumgartner, M., Mahendradhata, Y., Popovic, N. ... Digital Health Systems Collaborative (2025). The Digital Health Competencies in Medical Education Framework: An International Consensus Statement Based on a Delphi Study. JAMA network open, 8(1), Article e2453131. https://doi.org/10.1001/jamanetworkopen.2024.53131
Wang, X., Nursyifa, C., Aninta, S. G., Garcia-Erill, G., Bertola, L. D., Khan, A., Kuja, J., Hanghøj, K., Meisner, J., Bøggild, T., Bradshaw, C. J. A., Al-Chaer, A., Persada, A. P., Priyono, D. S., Tribudi, Y. A., Sudrajad, P., Gaina, C. D., Jiang, Y., Lenstra, J. A. ... Heller, R. (2025). The genetic diversity of Indonesian cattle has been shaped by multiple introductions and adaptive introgression. Nature Communications, 16(1), Article 8192. https://doi.org/10.1038/s41467-025-62692-z
Conover, C. A. & Oxvig, C. (2025). The IGF System and Aging. Endocrine Reviews, 46(2), 214-223. https://doi.org/10.1210/endrev/bnae029
Peña-Díaz, S., Jiang, Y., Zhang, Z., Daugberg, A., Ferreira, P., López Hernández, M., Mittal, C., Ramos, M. J., Pedersen, J. S., Dueholm, M. K. D., Qin, C., Wang, H. & Otzen, D. E. (2025). The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid. Advanced Science, Article e17090. Advance online publication. https://doi.org/10.1002/advs.202517090
Montiel, J., García-Soto, I., Monroy-Morales, E., Lace, B., Robledo-Gamboa, M., Vestergaard, M., Sandal, N., Ott, T. & Stougaard, J. (2025). The Lotus japonicus alpha-expansin EXPA1 is recruited during intracellular and intercellular rhizobial colonization. Plant Journal, 124(5), Article e70639. https://doi.org/10.1111/tpj.70639
Marzookian, K., Aliakbari, F., Hourfar, H., Sabouni, F., Otzen, D. E. & Morshedi, D. (2025). The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier. International Journal of Biological Macromolecules, 304(Part 1), Article 140387. https://doi.org/10.1016/j.ijbiomac.2025.140387

Peer-reviewed publications at MBG - all years

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Bryzek, D., Gasiorek, A., Kowalczyk, D., Santocki, M., Ciaston, I., Dobosz, E., Kolaczkowska, E., Kjøge, K., Kantyka, T., Lech, M., Potempa, B., Enghild, J. J., Potempa, J. & Koziel, J. (2025). Non-classical neutrophil extracellular traps induced by PAR2-signaling proteases. Cell Death & Disease, 16(1), Article 109. https://doi.org/10.1038/s41419-025-07428-z
Talay, A., Belikov, A. V., To, P. K. P., Alfatemi, H. H., Alon, U., Deelen, J., Ewald, C. Y., Gems, D., Gorbunova, V., Gruber, J., Hägg, S., Hemming, J., Horvath, S., Kaya, A., Lewis, C. J., Maier, A. B., Marinova, M. B., Pawelec, G., Peleg, S. ... de Magalhães, J. P. (2025). Open problems in ageing science: a roadmap for biogerontology. GeroScience. Advance online publication. https://doi.org/10.1007/s11357-025-01964-4
Mirab, F., Pirhaghi, M., Otzen, D. E. & Saboury, A. A. (2025). Parkinson's disease and gut microbiota metabolites: The dual impact of vitamins and functional amyloids. B B A - Molecular Basis of Disease, 1871(6), Article 167862. https://doi.org/10.1016/j.bbadis.2025.167862
Waligórska, I., Żak, K. M., Mikrut, N., Budziaszek, J., Medviediev, V., Bielecka, E., Kantyka, T., Kozieł, J., Thøgersen, I. B., Enghild, J. J., Grudnik, P., Potempa, J. & Książek, M. (2025). Periodontopathogens degrade angiotensin I from the human renin-angiotensin system through surface-attached proteases. Scientific Reports, 15(1), Article 43309. https://doi.org/10.1038/s41598-025-27891-0
Schlosser, A., Pilecki, B., Allen, C., Benest, A. V., Lynch, A. P., Hua, J., Ved, N., Blackley, Z., Andersen, T. L., Hennig, D., Graversen, J. H., Möller, S., Skallerup, S., Ormhøj, M., Lange, C., Agostini, H. T., Grauslund, J., Heegaard, S., Dacheva, I. ... Sorensen, G. L. (2025). Pharmacological blocking of microfibrillar-associated protein 4 reduces retinal neoangiogenesis and vascular leakage. Molecular Therapy, 33(3), 1048-1072. https://doi.org/10.1016/j.ymthe.2025.01.038
Jansen, S. A. H., Dreyer, L. S. A., van Basten, J., Yao, Y., Otzen, D. E., de Greef, T. F. A., Knowles, T. P. J., Meijer, E. W. & Erkamp, N. A. (2025). PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning. ACS Nano, 19(45), 38981-38989. https://doi.org/10.1021/acsnano.5c07268
Zhang, X., Grove, J., Gu, Y., Buus, C. K., Nielsen, L. K., Neufeld, S. A. S., Koko, M., Malawsky, D. S., Wade, E. M., Verhoef, E., Gui, A., Hegemann, L., Geschwind, D. H., Wray, N. R., Havdahl, A., Ronald, A., St Pourcain, B., Robinson, E. B., Bourgeron, T. ... APEX consortium (2025). Polygenic and developmental profiles of autism differ by age at diagnosis. Nature, 646(8087), 1146-1155. https://doi.org/10.1038/s41586-025-09542-6
Smit, R. A. J., Wade, K. H., Hui, Q., Arias, J. D., Yin, X., Christiansen, M. R., Yengo, L., Preuss, M. H., Nakabuye, M., Rocheleau, G., Graham, S. E., Buchanan, V. L., Chittoor, G., Graff, M., Guindo-Martínez, M., Lu, Y., Marouli, E., Sakaue, S., Spracklen, C. N. ... VA Million Veteran Program (2025). Polygenic prediction of body mass index and obesity through the life course and across ancestries. Nature Medicine, 31(9), 3151-3168. https://doi.org/10.1038/s41591-025-03827-z
Henches, L., Kim, J., Yang, Z., Rubinacci, S., Pires, G., Albiñana, C., Boetto, C., Julienne, H., Frouin, A., Auvergne, A., Suzuki, Y., Djebali, S., Delaneau, O., Ganna, A., Vilhjálmsson, B., Privé, F. & Aschard, H. (2025). Polygenic risk score prediction accuracy convergence. Human Genetics and Genomics Advances, 6(3), Article 100457. https://doi.org/10.1016/j.xhgg.2025.100457
Martín-Rivada, Á., Martos-Moreno, G., Guerra-Cantera, S., Campillo-Calatayud, A., Oxvig, C., Frystyk, J., Chowen, J. A., Barrios, V. & Argente, J. (2025). Prepubertal Children With Obesity Have High Free IGF-1 Levels and Accelerated Growth Despite Reduced Pappalysin Levels. Journal of Clinical Endocrinology and Metabolism, 110(3), e622-e629. https://doi.org/10.1210/clinem/dgae288
Kawamura, Y. K., Ozonov, E. A., Papasaikas, P., Kondo, T., Nguyen, N. V., Stadler, M. B., Smallwood, S. A., Koseki, H. & Peters, A. H. F. M. (2025). Preventing CpG hypermethylation in oocytes safeguards mouse development. Developmental Cell, 60(23), 3285-3303.e9. https://doi.org/10.1016/j.devcel.2025.08.005
Ismail, S., Kubíková, J., Maichel, M., Andersen, P. & Jeske, M. (2025). Probing direct interactions between nuclear proteins in cells with nxReLo. Proceedings of the National Academy of Sciences of the United States of America, 122(48), Article e2518711122. https://doi.org/10.1073/pnas.2518711122
Biswas, D., Liu, Y. H., Herrero, J., Wu, Y., Moore, D. A., Karasaki, T., Grigoriadis, K., Lu, W. T., Veeriah, S., Naceur-Lombardelli, C., Magno, N., Ward, S., Frankell, A. M., Hill, M. S., Colliver, E., de Carné Trécesson, S., East, P., Malhi, A., Snell, D. M. ... TRACERx Consortium (2025). Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma. Nature Cancer, 6(1), 86-101. Article 10110. https://doi.org/10.1038/s43018-024-00883-1
Fabbrizio, P., Baindoor, S., Margotta, C., Su, J., Morrissey, E. P., Woods, I., Hogg, M. C., Vianello, S., Venø, M. T., Kjems, J., Sorarù, G., Bendotti, C., Prehn, J. H. M. & Nardo, G. (2025). Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications. Brain Pathology, 35(4), Article e13328. https://doi.org/10.1111/bpa.13328
Demontis, D., Duan, J., Hsu, Y.-H. H., Pintacuda, G., Grove, J., Nielsen, T. T., Thirstrup, J., Martorana, M., Botts, T., Satterstrom, F. K., Bybjerg-Grauholm, J., Tsai, J. H. Y., Glerup, S., Hoogman, M., Buitelaar, J., Klein, M., Ziegler, G. C., Jacob, C., Grimm, O. ... Børglum, A. D. (2025). Rare genetic variants confer a high risk of ADHD and implicate neuronal biology. Nature. Advance online publication. https://doi.org/10.1038/s41586-025-09702-8
Zhang, C., Reid, K., Schierup, M. H., Wang, H., Candolin, U. & Merilä, J. (2025). Rate of de novo mutations in the three-spined stickleback. Heredity, 134(7), 387-395. https://doi.org/10.1038/s41437-025-00767-9
Riedelbauch, S., Masser, S., Fasching, S., Lin, S. Y., Salgania, H. K., Aarup, M., Ebert, A., Jeske, M., Levine, M. T., Stelzl, U. & Andersen, P. (2025). Recurrent innovation of protein-protein interactions in the Drosophila piRNA pathway. EMBO Journal, Article 98. Advance online publication. https://doi.org/10.1038/s44318-025-00439-8
Golan, N., Parizat, A., Tabachnikov, O., Barnea, E., Olsen, W. P., Otzen, D. E. & Landau, M. (2025). Resilience and Charge-Dependent Fibrillation of functional amyloid: Interactions of Pseudomonas Biofilm-Associated FapB and FapC Amyloids. The Journal of Biological Chemistry, 301(2), Article 108096. https://doi.org/10.1016/j.jbc.2024.108096
Kefalopoulou, S., Rullens, P. M. J., de Luca, K. L., de Vries, S. S., Korthout, T., van Oudenaarden, A., Zeller, P. & Kind, J. (2025). Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation. Nature Cell Biology, 27(7), 1186-1198. https://doi.org/10.1038/s41556-025-01687-w
Gobet, A., Moissonnier, L., Zarkadas, E., Magnard, S., Bettler, E., Martin, J., Terreux, R., Schoehn, G., Orelle, C., Jault, J. M., Falson, P. & Chaptal, V. (2025). Rhodamine6G and Hœchst33342 narrow BmrA conformational spectrum for a more efficient use of ATP. Nature Communications, 16(1), Article 1745. https://doi.org/10.1038/s41467-025-56849-z
Stenberg, K., Korhonen, S., Seemab, U., Dupont, D. M., Kjems, J., Honkakoski, P. & Subrizi, A. (2025). Selection of locally administered ocular tissue-targeting RNA aptamers using in vivo SELEX. European Journal of Pharmaceutical Sciences, 212, Article 107217. https://doi.org/10.1016/j.ejps.2025.107217
Baindoor, S., Gibriel, H. A. Y., Kool, L., Su, J., Demaegd, K. C., Venø, M. T., Van Den Berg, L. H., Kjems, J., Van Es, M. A. & Prehn, J. H. M. (2025). Serum small non-coding RNA define molecular subtypes in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. Advance online publication. https://doi.org/10.1080/21678421.2025.2574690
Hollingshead, S., McVicker, G., Nielsen, M. R., Zhang, Y., Pilla, G., Jones, R. A., Thomas, J. C., Johansen, S. E. H., Exley, R. M., Brodersen, D. E. & Tang, C. M. (2025). Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system. mBio, 16(2), e0261624. https://doi.org/10.1128/mbio.02616-24
Blotenburg, M., Suurenbroek, L., Bax, D., de Visser, J., Bhardwaj, V., Braccioli, L., de Wit, E., van Boxtel, A., Marks, H. & Zeller, P. (2025). Stem cell culture conditions affect in vitro differentiation potential and mouse gastruloid formation. PLoS One, 20(3), Article e0317309. https://doi.org/10.1371/journal.pone.0317309
Nel, L., Thaysen, K., Jamecna, D., Olesen, E., Langer, J., Frain, K. M., Szomek, M., Höglinger, D., Wüstner, D. & Pedersen, B. P. (2025). Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related protein. Life Science Alliance, 8(1), Article e202402990. https://doi.org/10.26508/lsa.202402990
Rotilio, L., Bayer, T., Meinert, H., Teixeira, L. M. C., Johansen, M. B., Sommerfeldt, A., Petersen, A. R., Sandahl, A., Keller, M. B., Holck, J., Paiva, P., Otzen, D. E., Bornscheuer, U. T., Wei, R., Fernandes, P. A., Ramos, M. J., Westh, P. & Morth, J. P. (2025). Structural and Functional Characterization of an Amidase Targeting a Polyurethane for Sustainable Recycling. Angewandte Chemie International Edition, 64(7), Article e202419535. https://doi.org/10.1002/anie.202419535