Peer-reviewed articles

Publications from the department

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Peer-reviewed publications at MBG - 2025

Korsgaard, U., Kristensen, M. P., García-Rodríguez, J. L., Kjær-Frifeldt, S., Lindebjerg, J., Hansen, T. F., Kjems, J., Hager, H. & Kristensen, L. S. (2025). The prognostic potential of RNA in stage II colon cancer: Insights from a screened multicenter population-based cohort study. International Journal of Cancer, 157(8), 1746-1755. https://doi.org/10.1002/ijc.35507

Kjeldsen, C. M. N. & Oxvig, C. (2025). The Proteinase PAPP-A has Deep Evolutionary Roots Outside of the IGF System. Genome Biology and Evolution, 17(3), Article evaf042. https://doi.org/10.1093/gbe/evaf042

Segur-Bailach, E., Mateu-Bosch, A., Bofill-De Ros, X., Parés, M., da Silva Buttkus, P., Rathkolb, B., Gailus-Durner, V., Hrabě de Angelis, M., Moeini, P., Gonzalez-Aseguinolaza, G., Tort, F., Ribes, A., van Karnebeek, C. D. M., García-Villoria, J. & Fillat, C. (2025). Therapeutic AASS inhibition by AAV-miRNA rescues glutaric aciduria type I severe phenotype in mice. Molecular Therapy, 33(10), 4820-4833. https://doi.org/10.1016/j.ymthe.2025.07.022

Christiansen, G. B., Petersen, L. V., Chatwin, H., Yilmaz, Z., Schendel, D., Bulik, C. M., Grove, J., Brikell, I., Semark, B. D., Holde, K., Abdulkadir, M., Hübel, C., Albiñana, C., Vilhjálmsson, B. J., Børglum, A. D., Demontis, D., Mortensen, P. B. & Larsen, J. T. (2025). The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder. Molecular Psychiatry, 30(5), 2127-2136. Article 132. https://doi.org/10.1038/s41380-024-02825-w

Poulsen, E. T., Nielsen, N. S. & Enghild, J. J. (2025). The role of the extracellular matrix in TGFBI-related corneal dystrophy development. In E. K. Kim & R. D. Stulting (Eds.), TGFBI-related Corneal Dystrophies: Clinical Findings, Cell Biology, and Genetics (pp. 77-94). Springer. https://doi.org/10.1007/978-981-96-0131-8_9

Shah, A., Zhang, X., Snee, M., Lockhart-Cairns, M. P., Levy, C. W., Jowitt, T. A., Birchenough, H. L., Dean, L., Collins, R., Dodd, R. J., Roberts, A. R. E., Enghild, J. J., Mantovani, A., Fontana, J., Baldock, C., Inforzato, A., Richter, R. P. & Day, A. J. (2025). The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix. Matrix biology : journal of the International Society for Matrix Biology, 136, 52-68. https://doi.org/10.1016/j.matbio.2025.01.002

O’Leary, E., Jiang, Y., Kristensen, L. S., Hansen, T. B. & Kjems, J. (2025). The therapeutic potential of circular RNAs. Nature Reviews Genetics, 26(4), 230-244. Article 2629. https://doi.org/10.1038/s41576-024-00806-x

Fedosov, S. N. (2025). The uptake of ingested vitamin B12 and its total body balance: a mathematical model suggests the optimal supplementation strategy. Biochimie. Advance online publication. https://doi.org/10.1016/j.biochi.2025.12.002

Almeida, A. V., Jensen, K. T., Harwood, S. L., Jørgensen, M. H., Nielsen, N. S., Thøgersen, I. B., Enghild, J. J. & Andersen, G. R. (2025). Three cryo-EM structures of CD109 reveal its mechanism of protease inhibition. Cell Reports, 44(6), Article 115787. https://doi.org/10.1016/j.celrep.2025.115787

McLain, A., Saffie-Siebert, S. R., Nielsen, N. S., Patterson, B., Scavenius, C., Enghild, J. J., Marshall, J., Baran-Rachwalska, P., Welsh, M., Sutera, F. M., Moore, L., Willoughby, C., Nesbit, M. A. & Moore, T. (2025). Topical mutant allele-specific siRNA delivery for treatment of Meesmann epithelial corneal dystrophy and elucidation of disease biomarkers. Journal of Controlled Release, 388, Article 114315. https://doi.org/10.1016/j.jconrel.2025.114315

André, A. A. M., Rehnberg, N., Garg, A. & Kjærgaard, M. (2025). Toward Design Principles for Biomolecular Condensates for Metabolic Pathways. Advanced Biology, 9(5), Article 2400672. https://doi.org/10.1002/adbi.202400672

TRACERx Consortium (2025). TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling. Nature Cell Biology, 27(1), 154-168. Article 4871. https://doi.org/10.1038/s41556-024-01558-w

Paiva, P., Teixeira, L. M. C., Ferreira, P., Otzen, D. E., Fernandes, P. A. & Ramos, M. J. (2025). Transforming Computational Power into Environmental Solutions: HPC-driven Research on Urethanase-mediated Plastic Degradation. Procedia Computer Science, 267, 207-217. https://doi.org/10.1016/j.procs.2025.08.247

Hu, Q., Sitsel, O., Bågenholm, V., Grønberg, C., Lyu, P., Pii Svane, A. S., Andersen, K. R., Laursen, N. S., Meloni, G., Nissen, P., Juhl, D. W., Nielsen, J. T., Nielsen, N. C. & Gourdon, P. (2025). Transition metal transporting P-type ATPases: terminal metal-binding domains serve as sensors for autoinhibitory tails. FEBS journal, 292(7), 1654-1674. https://doi.org/10.1111/febs.17330

Schulz, L., Ung, K. L., Zuzic, L., Koutnik-Abele, S., Schiøtt, B., Stokes, D. L., Pedersen, B. P. & Hammes, U. Z. (2025). Transport of phenoxyacetic acid herbicides by PIN-FORMED auxin transporters. Nature Plants, 11(5), 1049-1059. https://doi.org/10.1038/s41477-025-01984-0

Auxillos, J., Stigliani, A., Vaagensø, C. S., Garland, W., Niazi, A. M., Valen, E., Jensen, T. H. & Sandelin, A. (2025). True length of diverse capped RNA sequencing (TLDR-seq): 5'-3'-end sequencing of capped RNAs regardless of 3'-end status. Nucleic Acids Research, 53(6), Article gkaf240. https://doi.org/10.1093/nar/gkaf240

Tsitsikli, M., Simonsen, B., Luu, T. B., Larsen, M. M., Andersen, C. G., Gysel, K., Lironi, D., Krönauer, C., Rübsam, H., Hansen, S. B., Bærentsen, R., Wulff, J. L., Johansen, S. H., Sezer, G., Stougaard, J., Andersen, K. R. & Radutoiu, S. (2025). Two residues reprogram immunity receptors for nitrogen-fixing symbiosis. Nature, 648(8093), 443-450. https://doi.org/10.1038/s41586-025-09696-3

TRACERx Consortium (2025). Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma. Nature Medicine, 31(1), 70-76. https://doi.org/10.1038/s41591-024-03216-y

M. Løber, I. M., Hedemann, M. S., Villesen, P. & Nielsen, K. L. (2025). Untangling the Postmortem Metabolome: A Machine Learning Approach for Accurate PMI Estimation. Analytical Chemistry, 97(30), 16123-16132. https://doi.org/10.1021/acs.analchem.4c05796

Paiva, P., Teixeira, L. M. C., Wei, R., Liu, W., Weber, G., Morth, J. P., Westh, P., Petersen, A. R., Johansen, M. B., Sommerfeldt, A., Sandahl, A., Otzen, D. E., Fernandes, P. A. & Ramos, M. J. (2025). Unveiling the enzymatic pathway of UMG-SP2 urethanase: insights into polyurethane degradation at the atomic level. Chemical Science, 16(5), 2437-2452. https://doi.org/10.1039/d4sc06688j

Hollensen, A. K., Sørensen, M. H., Thomsen, S. V., Thomsen, H. S. & Damgaard, C. K. (2025). Using circular RNAs to target toxic RNA-binding proteins in amyotrophic lateral sclerosis. Molecular Therapy Methods and Clinical Development, 33(3), Article 101525. https://doi.org/10.1016/j.omtm.2025.101525

Ghouse, J., Ahlberg, G., Albertsen Rand, S., Salling Olesen, M., Vilhjalmsson, B., Stender, S. & Bundgaard, H. (2025). Within-person stability of lipoprotein(a) concentration. European Heart Journal, 46(12), 1159-1161. https://doi.org/10.1093/eurheartj/ehae652

Eg Gadegaard, I. S., Eskildsen, M. H., Østergaard, S. K., Nielsen, J. L. & Rasmussen, J. T. (2025). Xanthine oxidase-lactoperoxidase system: Dose-dependent antibacterial effects and global gene expression changes in infant oral microbiota. Food Research International, 201, Article 115596. https://doi.org/10.1016/j.foodres.2024.115596

Shiraz, M. G., Nielsen, J., Widmann, J., Chung, K. H. K., Davis, T. P., Rasmussen, C., Scavenius, C., Enghild, J. J., Martin-Gallausiaux, C., Singh, Y., Javed, I. & Otzen, D. E. (2025). Young rat microbiota extracts strongly inhibit fibrillation of α-synuclein and protect neuroblastoma cells and zebrafish against α-synuclein toxicity. Molecules and Cells, 48(1), Article 100161. https://doi.org/10.1016/j.mocell.2024.100161

Pravata, V. M., Jiang, H., Ferenbach, A. T., Lamond, A. & van Aalten, D. M. F. (2025). Zscan4 as a Candidate Conveyor of Early Developmental Defects in O-GlcNAc Transferase Intellectual Disability. Molecular & Cellular Proteomics : MCP, 24(11), Article 101077. https://doi.org/10.1016/j.mcpro.2025.101077

Christiansen, M. P. V. & Hammer, B. (2025). Δ-model correction of foundation model based on the model’s own understanding. Journal of Chemical Physics, 162(18), Article 184701. https://doi.org/10.1063/5.0268264

Displaying results 201 to 226 out of 226

Peer-reviewed publications at MBG - all years

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Dubiez, E., Garland, W., Finderup Brask, M., Boeri Erba, E., Heick Jensen, T., Kadlec, J. & Cusack, S. (2025). Structural basis for the synergistic assembly of the snRNA export complex. Nature Structural and Molecular Biology, 32(8), 1555-1566. https://doi.org/10.1038/s41594-025-01595-5

Thorsen, T. S., Kulkarni, Y., Sykes, D. A., Bøggild, A., Drace, T., Hompluem, P., Iliopoulos-Tsoutsouvas, C., Nikas, S. P., Daver, H., Makriyannis, A., Nissen, P., Gajhede, M., Veprintsev, D. B., Boesen, T., Kastrup, J. S. & Gloriam, D. E. (2025). Structural basis of THC analog activity at the Cannabinoid 1 receptor. Nature Communications, 16(1), Article 486. https://doi.org/10.1038/s41467-024-55808-4

Silale, A., Madej, M., Mikruta, K., Frey, A. M., Hart, A. J., Baslé, A., Scavenius, C., Enghild, J. J., Trost, M., Hirt, R. P. & van den Berg, B. (2025). Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota. Nature Microbiology, 10(11), 2845-2859. https://doi.org/10.1038/s41564-025-02132-2

Basse Hansen, S., Flygaard, R. K., Kjaergaard, M. & Nissen, P. (2025). Structure of the [Ca]E2P intermediate of Ca²⁺-ATPase 1 from Listeria monocytogenes. EMBO Reports, 26(7), 1709-1723. Article eadd9742. https://doi.org/10.1038/s44319-025-00392-x

Ung, K. L., Schulz, L., Zuzic, L., Amsinck, B. L., Koutnik-Abele, S., Benhammouche, I., Andersen, C. G., Nel, L., Schiøtt, B., Stokes, D. L., Hammes, U. Z. & Pedersen, B. P. (2025). Structures and mechanism of the AUX/LAX transporters involved in auxin import. Nature Plants, 11(8), 1670-1680. https://doi.org/10.1038/s41477-025-02056-z

Singh, P., Kadam, N. Y., Panigrahi, R., Mehrotra, A., Upadhayay, K., Dey, M., Tyagi, A., Aquib, M., Nielsen, J., Kleijwegt, G., Singh, P., Sharma, A., Rao, A., Otzen, D. E., Kumar, A. & Sharma, D. (2025). Sulfamerazine as a Potential Modulator against α-Synuclein Aggregation and Associated Toxicity. ACS Chemical Neuroscience, 16(5), 880-894. https://doi.org/10.1021/acschemneuro.4c00803

ICTV Taxonomy Summary Consortium (2025). Summary of taxonomy changes ratified by the International Committee on Taxonomy of Viruses (ICTV) from the Fungal and Protist Viruses Subcommittee, 2025. The Journal of general virology, 106(7), Article 002115. https://doi.org/10.1099/jgv.0.002115

Tang, A. A., Gobry, M. V., Li, S., Andersen, E. S. & Franco, E. (2025). Switchable RNA motifs for dynamic transcriptional control of RNA condensates. Nucleic Acids Research, 53(12), Article gkaf497. https://doi.org/10.1093/nar/gkaf497

Selten, G., Gómez-Repollés, A., Lamouche, F., Radutoiu, S. & de Jonge, R. (2025). SyFi: generating and using sequence fingerprints to distinguish SynCom isolates. Microbial Genomics, 11(9), Article 001461. https://doi.org/10.1099/mgen.0.001461

Zaheer, S., Baindoor, S., Connolly, N. M. C., Siebenbrodt, K., Bauer, S., Rosenow, F., Andersen, J. S., Venø, M. T., Kjems, J., Henshall, D. C. & Prehn, J. H. M. (2025). Temporal Dynamics of tsRNA Regulation Mark an Abrupt Transition After Epileptogenesis. Journal of Neurochemistry, 169(12), Article e70317. https://doi.org/10.1111/jnc.70317

McLain, A., Kowalczyk, A., Baran-Rachwalska, P., Sutera, F. M., Robertson, L. J., Nielsen, N. S., Enghild, J. J., Cobice, D., Bonelli, F., Barbaro, V., Ferrari, S., Patterson, B., Moore, L., Marshall, J., Nesbit, M. A. & Moore, T. (2025). TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery. Journal of Controlled Release, 382, Article 113681. https://doi.org/10.1016/j.jconrel.2025.113681

Malham, M., Vestergaard, M. V., Bataillon, T., Villesen, P., Dempfle, A., Bang, C., Engsbro, A. L., Jakobsen, C., Franke, A., Wewer, V., Thingholm, L. B. & Petersen, A. M. (2025). The Composition of the Fecal and Mucosa-adherent Microbiota Varies Based on Age and Disease Activity in Ulcerative Colitis. Inflammatory Bowel Diseases, 31(2), 501-513. https://doi.org/10.1093/ibd/izae179

Car, J., Ong, Q. C., Erlikh Fox, T., Leightley, D., Kemp, S. J., Švab, I., Tsoi, K. K. F., Sam, A. H., Kent, F. M., Hertelendy, A. J., Longhurst, C. A., Powell, J., Hamdy, H., Nguyen, H. V. Q., Aoun Bahous, S., Wang, M., Baumgartner, M., Mahendradhata, Y., Popovic, N. ... Digital Health Systems Collaborative (2025). The Digital Health Competencies in Medical Education Framework: An International Consensus Statement Based on a Delphi Study. JAMA network open, 8(1), Article e2453131. https://doi.org/10.1001/jamanetworkopen.2024.53131

Wang, X., Nursyifa, C., Aninta, S. G., Garcia-Erill, G., Bertola, L. D., Khan, A., Kuja, J., Hanghøj, K., Meisner, J., Bøggild, T., Bradshaw, C. J. A., Al-Chaer, A., Persada, A. P., Priyono, D. S., Tribudi, Y. A., Sudrajad, P., Gaina, C. D., Jiang, Y., Lenstra, J. A. ... Heller, R. (2025). The genetic diversity of Indonesian cattle has been shaped by multiple introductions and adaptive introgression. Nature Communications, 16(1), Article 8192. https://doi.org/10.1038/s41467-025-62692-z

Ma, J., Bechsgaard, J. S., Lauridsen, A. A., Villesen, P., Bilde, T. & Schierup, M. H. (2025). The genomic consequences and persistence of sociality in spiders. Genome Research, 35(3), 499-511. https://doi.org/10.1101/gr.279503.124

Conover, C. A. & Oxvig, C. (2025). The IGF System and Aging. Endocrine Reviews, 46(2), 214-223. https://doi.org/10.1210/endrev/bnae029

Peña-Díaz, S., Jiang, Y., Zhang, Z., Daugberg, A., Ferreira, P., López Hernández, M., Mittal, C., Ramos, M. J., Pedersen, J. S., Dueholm, M. K. D., Qin, C., Wang, H. & Otzen, D. E. (2025). The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid. Advanced Science, Article e17090. Advance online publication. https://doi.org/10.1002/advs.202517090

Montiel, J., García-Soto, I., Monroy-Morales, E., Lace, B., Robledo-Gamboa, M., Vestergaard, M., Sandal, N., Ott, T. & Stougaard, J. (2025). The Lotus japonicus alpha-expansin EXPA1 is recruited during intracellular and intercellular rhizobial colonization. Plant Journal, 124(5), Article e70639. https://doi.org/10.1111/tpj.70639

Simonsen, B., Rübsam, H., Kolte, M. V., Larsen, M. M., Krönauer, C., Gysel, K., Laursen, M., Feng, F., Sezer, G., Oldroyd, G. E. D., Stougaard, J., Fort, S., Radutoiu, S. & Andersen, K. R. (2025). The Medicago truncatula LYR4 intracellular domain serves as a scaffold in immunity signaling independent of its phosphorylation activity. New Phytologist, 246(4), 1423-1431. https://doi.org/10.1111/nph.70067

Marzookian, K., Aliakbari, F., Hourfar, H., Sabouni, F., Otzen, D. E. & Morshedi, D. (2025). The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier. International Journal of Biological Macromolecules, 304(Part 1), Article 140387. https://doi.org/10.1016/j.ijbiomac.2025.140387

Kofod Petersen, A., Villesen, P. & Staun Larsen, L. (2025). The oral fingerprint: rapid 3D comparison of palatal rugae for forensic identification. Frontiers in Radiology, 5, Article 1638294. https://doi.org/10.3389/fradi.2025.1638294

Pedersen, E. M., Wimberley, T. & Vilhjálmsson, B. J. (2024). A cautionary tale for Alzheimer’s disease GWAS by proxy: Genetic epidemiology. Nature Genetics, 56(12), 2590-2591. Article 99. https://doi.org/10.1038/s41588-024-02023-y

García-Soto, I., Andersen, S. U., Monroy-Morales, E., Robledo-Gamboa, M., Guadarrama, J., Aviles-Baltazar, N. Y., Serrano, M., Stougaard, J. & Montiel, J. (2024). A collection of novel Lotus japonicus LORE1 mutants perturbed in the nodulation program induced by the Agrobacterium pusense strain IRBG74. Frontiers in Plant Science, 14, Article 1326766. https://doi.org/10.3389/fpls.2023.1326766

Hansen, S. B., Luu, T. B., Gysel, K., Lironi, D., Krönauer, C., Rübsam, H., Jensen, I. B., Tsitsikli, M., Birkefeldt, T. G., Trgovcevic, A., Stougaard, J., Radutoiu, S. & Andersen, K. R. (2024). A conserved juxtamembrane motif in plant NFR5 receptors is essential for root nodule symbiosis. Proceedings of the National Academy of Sciences of the United States of America, 121(46), Article e2405671121. https://doi.org/10.1073/pnas.2405671121

Displaying results 201 to 250 out of 5446

Open Access

Revised 13.11.2025

Lisbeth Heilesen

Department of Molecular Biology and Genetics

Peer-reviewed articles

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Peer-reviewed publications at MBG - 2025

Peer-reviewed publications at MBG - all years

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