Molecular and translational neuroscience - DANDRITE

The Danish Research Institute of Translational Neuroscience – DANDRITE

is the Danish node of the Nordic EMBL Partnership for Molecular Medicine, and performs basic and translational research in brain and the nervous system.

Groups at DANDRITE encompass ambitious research programs that include:

Molecular and cellular mechanisms of memory
Effort-based decision making
Neuronal development and stem cells
Motor control
Brain processing of vision
Neurological and neurodegenerative diseases
Psychiatric disorders
Neurotrophic receptors, sorting
Structural biology of membrane transporters and receptors

Section coordinator at MBG/Director and Core Group Leader at DANDRITE

DANDRITE (Danish Research Institute of Translational Neuroscience)

Poul Nissen

Professor

M pn@mbg.au.dk
H 3130, 2.02
P +4587155508
P +4528992295

Research

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Group leaders at MBG/Group leaders at DANDRITE

Duda Kvitsiani

Group Leader, Associate Professor

M kvitsi@dandrite.au.dk
H 1182, 310

Research

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Sadegh Nabavi

Group Leader, Associate Professor

M snabavi@dandrite.au.dk
H 1182, 205
P +4593508246

Research

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Magnus Kjærgaard

Assistant Professor

M magnus@mbg.au.dk
H 3135, 2.10

Research

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Anne von Philipsborn

Group Leader, Associate Professor

M avp@dandrite.au.dk
H 1182, 204, lab. 220
P +4523359252

Research

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Thomas Boesen

Cryo-EM Facility Manager

M thb@mbg.au.dk
H 3130, 2.13
P +4587155435

Research

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Junior group leader at MBG/Team leader at DANDRITE

Esben Meldgaard Høgh Quistgaard

Assistant Professor

M eq@mbg.au.dk
H 3135, 2.11

Research

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Hanne Poulsen

Associate professor

M hp@mbg.au.dk
H 3132, 101
P +4530254065
P +4530254065

Research

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Peer-reviewed publications

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Gotfryd, K., Boesen, T., Mortensen, J. S., Khelashvili, G., Quick, M., Terry, D. S., Missel, J. W., LeVine, M. V., Gourdon, P., Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, C. J., Nissen, P. & Gether, U. (2020). X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release. Nature Communications, 11(1), [1005]. https://doi.org/10.1038/s41467-020-14735-w

Paulsen, E. S., Villadsen, J., Tenori, E., Liu, H., Bonde, D. F., Lie, M. A., Bublitz, M., Olesen, C., Autzen, H. E., Dach, I., Sehgal, P., Nissen, P., Møller, J. V., Schiøtt, B. & Christensen, SB. (2013). Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase. Journal of Medicinal Chemistry, 56(9), 3609-3619. https://doi.org/10.1021/jm4001083

Nilsson, J., Sengupta, J., Gursky, R., Kjeldgaard, M., Nissen, P. & Frank, J. (2008). Visualization of the eEF2-80S ribosome transition-state complex by cryo-electron microscopy. Journal of Molecular Biology, 382(1), 179-187.

Poulsen, H. D. & Engberg, M. (2001). Validation of psychiatric patients' statements on coercive measures. Acta Psychiatrica Scandinavica, 103(1), 60-65. https://doi.org/10.1111/j.1600-0447.2001.00146.x

Jørgensen, R., Ortiz, P. A., Carr-Schmid, A., Nissen, P., Kinzy, T. G. & Andersen, G. R. (2003). Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase. Nat. Struct. Biol. ,10, 379-385.

Hilbers, F., Kopec, W., Isaksen, T. J., Holm, T. H., Lykke-Hartmann, K., Nissen, P., Khandelia, H. & Poulsen, H. (2016). Tuning of the Na,K-ATPase by the beta subunit. Scientific Reports, 6(20442). https://doi.org/10.1038/srep20442

Møller, J. V., Nissen, P., Sørensen, T. L-M. & le Maire, M. (2005). Transport mechanism of the sarcoplasmic reticulum Ca2+ATPase pump. Curr. Op. Struct. Biol., 15, 387-393.

Ravishankar, H., Pedersen, M. N., Eklund, M., Sitsel, A., Li, C., Duelli, A., Levantino, M., Wulff, M., Barth, A., Olesen, C., Nissen, P. & Andersson, M. (2020). Tracking Ca²⁺ ATPase intermediates in real time by x-ray solution scattering. Science Advances, 6(12), [eaaz0981]. https://doi.org/10.1126/sciadv.aaz0981

Nissen, P. (2019). Thomas A. Steitz (1940-2018). Acta crystallographica Section D: Structural biology , 75, 354-356. https://doi.org/10.1107/S2059798319002390

Doganli, C., Kjaer-Sørensen, K., Knoeckel, C., Beck, H. C., Nyengaard, J. R., Honoré, B., Nissen, P., Ribera, A., Oxvig, C. & Lykke-Hartmann, K. (2012). The α₂Na⁺/K⁺-ATPase is critical for skeletal and heart muscle function in zebrafish. Journal of Cell Science, 125, 6166-6175. https://doi.org/10.1242/jcs.115808

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Lisbeth Heilesen

Revised 22.09.2020