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Department of Molecular Biology and Genetics

Neurobiology

The Section for Neurobiology is part of the Danish Research Institute of Translational Neuroscience – DANDRITE

- the Danish node of the Nordic EMBL Partnership for Molecular Medicine, which performs basic and translational research in brain and the nervous system.

Groups at DANDRITE encompass ambitious research programs that include:

Molecular and cellular mechanisms of memory
Effort-based decision making
Neuronal development and stem cells
Motor control
Brain processing of vision
Neurological and neurodegenerative diseases
Psychiatric disorders
Neurotrophic receptors, sorting
Structural biology of membrane transporters and receptors

Read more about the research at DANDRITE.

Below you see the list of researchers at DANDRITE affiliated with the Department of Molecular Biology and Genetics.

List of staff and students in the research group

Group leaders

Professors

Associate Professors

Tenure Track Assistant Professor

Gilles Claude Vanwalleghem

Professor

Associate Professors

Tenure Track Assistant Professor

Peer-reviewed publications

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Lin, J., Bjørk, P. K., Kolte, M. V., Poulsen, E., Dedic, E., Drace, T., Andersen, S. U., Nadzieja, M., Liu, H., Castillo-Michel, H., Escudero, V., González-Guerrero, M., Boesen, T., Pedersen, J. S., Stougaard, J., Andersen, K. R. & Reid, D. (2024). Zinc mediates control of nitrogen fixation via transcription factor filamentation. Nature, 631(8019), 164-169. https://doi.org/10.1038/s41586-024-07607-6

Gotfryd, K., Boesen, T., Mortensen, J. S., Khelashvili, G., Quick, M., Terry, D. S., Missel, J. W., LeVine, M. V., Gourdon, P., Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, C. J., Nissen, P. & Gether, U. (2020). X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release. Nature Communications, 11(1), Article 1005. https://doi.org/10.1038/s41467-020-14735-w

Jensen, B. N., Wang, Y., Friec, A. L., Nabavi, S. . M. . S., Dong, MD., Seliktar, D. & Chen, M. (2023). Wireless electromagnetic neural stimulation patch with anisotropic guidance. npj Flexible Electronics, 7(1), Article 34. https://doi.org/10.1038/s41528-023-00270-3

Nielsen, L. S., Šantl-Temkiv, T., Palomeque Sánchez, M., Massling, A., Ward, J. C., Jensen, P. B., Boesen, T., Petters, M., Finster, K., Bilde, M. & Rosati, B. (2024). Water Uptake of Airborne Cells of P. syringae Measured with a Hygroscopicity Tandem Differential Mobility Analyzer. Environmental Science & Technology, 58(43), 19211-19221. https://doi.org/10.1021/acs.est.4c01817

Paulsen, E. S., Villadsen, J., Tenori, E., Liu, H., Bonde, D. F., Lie, M. A., Bublitz, M., Olesen, C., Autzen, H. E., Dach, I., Sehgal, P., Nissen, P., Møller, J. V., Schiøtt, B. & Christensen, SB. (2013). Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase. Journal of Medicinal Chemistry, 56(9), 3609-3619. https://doi.org/10.1021/jm4001083

Nilsson, J., Sengupta, J., Gursky, R., Kjeldgaard, M., Nissen, P. & Frank, J. (2008). Visualization of the eEF2-80S ribosome transition-state complex by cryo-electron microscopy. Journal of Molecular Biology, 382(1), 179-187.

Neumann, C., Focht, D., Trampari, S., Lyons, J. A. & Nissen, P. (2022). Variations on a theme: Crystal forms of the amino-acid transporter MhsT. Acta Crystallographica Section F: Structural Biology Communications, 78(Part 8), 297-305. https://doi.org/10.1107/S2053230X22007154

Verzelli, P., Nold, A., Sun, C., Heilemann, M., Schuman, E. M. & Tchumatchenko, T. (2022). Unbiased choice of global clustering parameters for single-molecule localization microscopy. Scientific Reports, 12(1), 22561. Article 22561. https://doi.org/10.1038/s41598-022-27074-1

Jørgensen, R., Ortiz, P. A., Carr-Schmid, A., Nissen, P., Kinzy, T. G. & Andersen, G. R. (2003). Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase. Nat. Struct. Biol. ,10, 379-385.

Hilbers, F., Kopec, W., Isaksen, T. J., Holm, T. H., Lykke-Hartmann, K., Nissen, P., Khandelia, H. & Poulsen, H. (2016). Tuning of the Na,K-ATPase by the beta subunit. Scientific Reports, 6(20442), Article 20442. https://doi.org/10.1038/srep20442

Kock Flygaard, R., Neumann, C., Anthony Lyons, J. & Nissen, P. (2021). Transport unplugged: KCCs are regulated through an N-terminal plug of the ion pathway. EMBO Journal, 40(14), Article e108371. https://doi.org/10.15252/embj.2021108371

Møller, J. V., Nissen, P., Sørensen, T. L.-M. & le Maire, M. (2005). Transport mechanism of the sarcoplasmic reticulum Ca2+ATPase pump. Curr. Op. Struct. Biol., 15, 387-393.

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Revised 13.11.2025

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Helene Eriksen