Department of Molecular Biology and Genetics

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 Department of Molecular Biology and Genetics Research Research areas RNA Biology and Innovation Xavier Bofill de Ros

Xavier Bofill de Ros

Research

MicroRNAs are a class of non-coding RNAs with essential roles in gene expression. Together, miRNAs regulate the expression of >60% of genes and deficiencies in their maturation, as well as their levels within cells, have been shown to drive several diseases including cancer. MicroRNAs are transcribed as longer transcripts, the maturation of which requires the adequate RNA folding and the precise cleavage of DROSHA and DICER1. This processing is aided by more than 180 RNA-binding proteins. The resulting products are mature microRNAs that provide specificity to Argonaute (AGO), a key component in RNA silencing.

We are interested in the following research topics:

  • Mechanisms of dysregulation of microRNA processing and function
  • Therapeutic opportunities based on small RNAs and RNA metabolism

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Peer-reviewed publications

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Yang, A., Bofill-De Ros, X., Stanton, R., Shao, T. J., Villanueva, P. & Gu, S. (2022). TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance. Nature Communications, 13(1), Article 5260. https://doi.org/10.1038/s41467-022-32969-8
Bofill-De Ros, X., Luke, B., Guthridge, R., Mudunuri, U., Loss, M. & Gu, S. (2021). Tumor IsomiR Encyclopedia (TIE): a pan-cancer database of miRNA isoforms. Bioinformatics, 37(18), 3023-3025. https://doi.org/10.1093/bioinformatics/btab172
Yang, A., Shao, T. J., Bofill-De Ros, X., Lian, C., Villanueva, P., Dai, L. & Gu, S. (2020). AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2. Nature Communications, 11(1), Article 2765. https://doi.org/10.1038/s41467-020-16533-w
Bofill-De Ros, X., Yang, A. & Gu, S. (2020). IsomiRs: Expanding the miRNA repression toolbox beyond the seed. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1863(4), Article 194373. https://doi.org/10.1016/j.bbagrm.2019.03.005
Dai, L., Hallmark, L., Bofill De Ros, X., Crouch, H., Chen, S., Shi, T., Yang, A., Lian, C., Zhao, Y., Tran, B. & Gu, S. (2020). Novel, abundant Drosha isoforms are deficient in miRNA processing in cancer cells. RNA Biology, 17(11), 1603-1612. https://doi.org/10.1080/15476286.2020.1813439

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Revised 13.11.2025
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Lisbeth Heilesen