Poul Nissen

A collection of P-type ATPase structures from the Nissen lab. Figure courtesy of Dr. Oleg Sitsel.

Research

Nissen group - Structural and Functional Studies of Membrane Proteins in Brain

The Nissen group investigates molecular mechanisms of membrane transport processes, receptors, and biomembrane ultrastructure. Activities are mainly focused on cryo-electron microscopy (Cryo-EM), protein crystallography, biochemistry, electrophysiology, and include also small-angle X-ray scattering and cryo-electron tomography. Main subjects of research concern membrane transporters and receptors involved with neurological and psychiatric disorders, i.e. P-type ATPase (Na,K-ATPase, Ca-ATPases, lipid flippases, P5-ATPases), Na+ dependent neurotransmitter and chloride transporters, and insulin receptor signaling. studies include also structure based drug discovery and protein engineering. Biomembrane ultrastructures of neurons focus on axons and synapses associated with memory.

Our investigations link also to translational studies of neurological and psychiatric disorders associated with perturbed ion transport or metabolic control.

Methods development and integrative structural biology and bioimaging is also of great interest to the group.

Research Areas: Membrane proteins, Membrane transport and signaling, single-particle Cryo-EM, Cryo-Electron Tomography, Crystallography, Biochemistry, Drug discovery

Movies

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Group photo Nissen lab (2025)

Structural Biology - past, present and future by Peter Moore

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Publications

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Pedersen, B. P., Morth, J. P. & Nissen, P. (2010). Structure determination using poorly diffracting membrane protein crystals - Lessons from the H+ and Na+,K+-ATPases. Acta Crystallographica. Section D: Biological Crystallography, 66, 309-313.

Møller, J. V., Olesen, C. E., Winther, A.-M. L. & Nissen, P. (2010). The sarcoplasmic Ca2+-ATPase: design of a perfect chemi-osmotic pump. Quarterly Reviews of Biophysics, 43(4), 501-566.

Boesecke, P., Bois, J. M., Crëpin, T., Hunte, C., Kahn, R., Kao, W.-C., Nauton, L., Winther, A.-M. L., Møller, J. V., Nissen, P., Nury, H., Olesen, C. E., Pebay-Peyroula, E., Vicat, J. & Stuhrmann, H. (2009). A first low-resolution difference Fourier map of phosphorus in a membrane protein from near-edge anomalous diffraction. Journal of Synchrotron Radiation, 16(5), 658-665.

Christensen, S. B., Skytte, D. M., Denmeade, S. R., Dionne, C., Møller, J. V., Nissen, P. & Isaacs, J. T. (2009). A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells. Anticancer Agents Med Chem, 9, 276-294.

Quick, M., Winther, A.-M. L., Shi, L., Nissen, P., Weinstein, H. & Javitch, J. A. (2009). Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proceedings of the National Academy of Sciences (PNAS), 106(14), 5563-8.

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Affiliated researcher of DANDRITE

The Danish Research Institute of Translational Neuroscience (DANDRITE) is the Danish node of the Nordic EMBL Partnership for Molecular Medicine. DANDRITE was established by Lundbeckfonden and Aarhus University in 2013 and performs basic and translational research in brain and the nervous system.

Partner of PROMEMO

PROMEMO is a Danish National Research Foundation Center of Excellence, studying the fundamental traits of learning and memory in healty and diseased brains.