2015

de Ford , C., Calderon, C., Sehgal, P., Fedosova, N., Murillo, R., Olesen, C., Nissen, P., Møller, J. V. & Merfort, I. (2015). Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca(2+)-ATPase Inhibitors and Structure-Activity Relationships. Journal of Natural Products, 78 (6), 1262–1270.

Zuccaro, L., Tesauro, C., Kurkina, T., Fiorani, P., Ki Yu, H., Knudsen, B. R., Kern, K., Desideri, A. & Balasubramanian, K. (2015). Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene. ACS Nano, 9(11), 11166-11176. https://doi.org/10.1021/acsnano.5b05709

Zocher, G., Vilstrup, J., Heine, D., Hallab, A., Goralski, E., Hertweck, C., Stahl, M., Schäberle, T. F. & Stehle, T. (2015). Structural basis of head to head polyketide fusion by CorB. Chemical Science, 6(11), 6525-6536. https://doi.org/10.1039/c5sc02488a

Zgadzaj, R., James, E. K., Kelly, S., Kawaharada, Y., de Jonge, N., Jensen, D. B., Madsen, L. H. & Radutoiu, S. (2015). A Legume Genetic Framework Controls Infection of Nodules by Symbiotic and Endophytic Bacteria. P L o S Genetics, 11(6), [1005280]. https://doi.org/10.1371/journal.pgen.1005280

Zeng, G., Vad, B. S., Dueholm, M. S., Christiansen, G., Nilsson, M., Tolker-Nielsen, T., Nielsen, P. H., Meyer, R. L. & Otzen, D. E. (2015). Functional bacterial amyloid increases Pseudomonas biofilm hydrophobicity and stiffness. Frontiers in Microbiology, 6, 1099. https://doi.org/10.3389/fmicb.2015.01099

Yatime, L., Maasch, C., Hoehlig, K., Klussmann, S., Andersen, G. R. & Vater, A. (2015). Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer. Nature Communications, 6, 1-13. [6481]. https://doi.org/10.1038/ncomms7481

Yang, C., Thomsen, R. P., Ogaki, R., Kjems, J. & Mian Teo, B. (2015). Ultrastable green fluorescence carbon dots with a high quantum yield for bioimaging and use as theranostic carriers. Journal of Materials Chemistry B, 3(4577), 4577-4584. https://doi.org/10.1039/C5TB00467E

Yang, C., Ogaki, R., Hansen, L., Kjems, J. & Mian Teo, B. (2015). Theranostic carbon dots derived from garlic with efficient anti-oxidative effects towards macrophages. R S C Advances, 118, 97836-97840. https://doi.org/10.1039/C5RA16874K

Xue, Y., Wang, L., Xia, D., Li, Q., Gao, S., Dong, MD., Cai, T., Shi, S., He, L., Hu, K., Mao, T. & Duan, X. (2015). Dental Abnormalities Caused by Novel Compound Heterozygous CTSK Mutations. Advances in Dental Research, 94(5), 674-681. https://doi.org/10.1177/0022034515573964

Xu, P., Xu, M., Jiang, L., Yang, Q., Luo, Z., Dauter, Z., Huang, M. & Andreasen, P. A. (2015). Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor. Journal of Medicinal Chemistry, 58(22), 8868-8876. https://doi.org/10.1021/acs.jmedchem.5b01128

Wong, J. E. M. M., Midtgaard, S. R., Gysel, K., Thygesen, M. B., Sørensen, K. K., Jensen, K. J., Stougaard, J., Thirup, S. & Blaise, M. (2015). An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase. Acta crystallographica Section D: Structural biology , 71(Pt 3), 592-605. https://doi.org/10.1107/S139900471402793X

Wolf, G., Yang, P., Füchtbauer, A. C., Füchtbauer, E-M., Silva, A. M., Park, C., Wu, W., Nielsen, A. L., Pedersen, F. S. & Macfarlan, T. S. (2015). The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses. Genes & Development, 29(5), 538-54. https://doi.org/10.1101/gad.252767.114

Winther, S., Svensson, M., Jørgensen, H. S., Bouchelouche, K., Gormsen, L. C., Pedersen, B. B., Holm, N. R., Bøtker, H. E., Ivarsen, P. & Bøttcher, M. (2015). Diagnostic Performance of Coronary CT Angiography and Myocardial Perfusion Imaging in Kidney Transplantation Candidates. JACC. Cardiovascular imaging. https://doi.org/10.1016/j.jcmg.2014.12.028

Westberg, M., Holmegaard, L., Pimenta, F. M., Etzerodt, M. & Ogilby, P. R. (2015). Rational design of an efficient, genetically encodable, protein-encased singlet oxygen photosensitizer. Journal of the American Chemical Society, 137(4), 1632-42. https://doi.org/10.1021/ja511940j

Wang, Z., D'Annessa, I., Tesauro, C., Croce, S., Ottaviani, A., Fiorani, P. & Desideri, A. (2015). Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation. BBA Proteins and Proteomics, 1854(8), 860-868. https://doi.org/10.1016/j.bbapap.2015.04.017

Wang, X., Ma, P., Liu, J., Zhang, Q., Zhang, Y., Ding, X., Jiang, L., Wang, Y., Zhang, Y., Sun, D., Zhang, S., Su, G., Yu, Y. & Zhang, Y. (2015). Genome-wide association study in Chinese Holstein cows reveal two candidate genes for somatic cell score as an indicator for mastitis susceptibility. BMC Genetics, 16(1), [111]. https://doi.org/10.1186/s12863-015-0263-3

Wack, A., Terczynska-Dyla, E. & Hartmann, R. (2015). Guarding the frontiers: the biology of type III interferons. Nature Immunology, 16(8), 802-809. https://doi.org/10.1038/ni.3212

Viuff, A. H., Besenbacher, L. M., Kamori, A., Jensen, M. T., Kilian, M., Kato, A. & Jensen, H. H. (2015). Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine. Organic & Biomolecular Chemistry, 13(37), 9637-58. https://doi.org/10.1039/c5ob01281c

Vetter, M. M., Wang, J., Lorentzen, E. & Deretic, D. (2015). Novel topography of the Rab11-effector interaction network within a ciliary membrane targeting complex. Small GTPases, 6(4), 165-173. https://doi.org/10.1080/21541248.2015.1091539

Venø, S. T., Witt, M. B., Kulikowicz, T., Bohr, V. A. & Stevnsner, T. (2015). Regulation of the human Suv3 helicase on DNA by inorganic cofactors. Biochimie, 108, 160-168. https://doi.org/10.1016/j.biochi.2014.11.003

Venø, M. T., Hansen, T. B., Venø, S. T., Clausen, B. H., Grebing, M., Finsen, B., Holm, I. E. & Kjems, J. (2015). Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development. Genome Biology, 16, [16:245]. https://doi.org/10.1186/s13059-015-0801-3

Vad, B. S., Balakrishnan, V. S., Nielsen, S. B. & Otzen, D. (2015). Phospholipid Ether Linkages Significantly Modulate the Membrane Affinity of the Antimicrobial Peptide Novicidin. Journal of Membrane Biology, 487-496. https://doi.org/10.1007/s00232-015-9792-y

Tudek, A., Candelli, T. & Libri, D. (2015). Non-coding transcription by RNA polymerase II in yeast: Hasard or nécessité? Biochimie, 117(Special Issue: Regulatory RNAs), 28-36. https://doi.org/10.1016/j.biochi.2015.04.020

Tiedje, C., Lubas, M., Tehrani, M., Menon, M. B., Ronkina, N., Rousseau, S., Cohen, P., Kotlyarov, A. & Gaestel, M. (2015). p38^MAPK/MK2-mediated phosphorylation of RBM₇ regulates the human nuclear exosome targeting complex. RNA, 21(2), 262-278. https://doi.org/10.1261/rna.048090.114

Tian, P., Boomsma, W., Wang, Y., Otzen, D., Jensen, M. H. & Lindorff-Larsen, K. (2015). Structure of a Functional Amyloid Protein Subunit Computed Using Sequence Variation. Journal of the American Chemical Society, 137(1), 22-25. https://doi.org/10.1021/ja5093634

Thomsen, J., Hjortebjerg, R., Espelund, U., Ørtoft, G., Vestergaard, P., Magnusson, N. E., Conover, C. A., Tramm, T., Hager, H., Høgdall, C., Høgdall, E., Oxvig, C. & Frystyk, J. (2015). PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma. OncoTarget, 6(31), 32266-32278. https://doi.org/10.18632/oncotarget.5010

Thirup, S. S., Van, L. B., Nielsen, T. K. & Knudsen, C. R. (2015). Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu. Journal of Structural Biology, 191(1), 10-21. https://doi.org/10.1016/j.jsb.2015.06.011

Thavachelvam, K., Gad, H. H., Ibsen, M. S., Desprès, P., Hokland, M., Hartmann, R. & Kristiansen, H. (2015). Rapid Uptake and Inhibition of Viral Propagation by Extracellular OAS1. Journal of Interferon & Cytokine Research, 35(2), 359-366. https://doi.org/10.1089/jir.2014.0140

Sørensen, C. S., Runager, K. S., Scavenius, C., Jensen, M. M., Nielsen, N. S., Christiansen, G., Petersen, S. V., Karring, H., Sanggaard, K. W. & Enghild, J. J. (2015). Fibril core of transforming growth factor beta-induced protein (TGFBIp) facilitates aggregation of corneal TGFBIp. Biochemistry, 19(54), 2943-2956. https://doi.org/10.1021/acs.biochem.5b00292

Sørensen, H. P., Xu, P., Jiang, L., Kromann-Hansen, T., Jensen, K. J., Huang, M. & Andreasen, P. A. (2015). Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions. Journal of Molecular Biology, 427(19), 3110-3122. https://doi.org/10.1016/j.jmb.2015.08.005

Søndergaard, M. T., Sorensen, A. B., Skov, L. L., Kjaer-Sorensen, K., Bauer, M. C., Nyegaard, M., Linse, S., Oxvig, C. & Overgaard, M. T. (2015). Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes. F E B S Journal, 282(4), 803-816. https://doi.org/10.1111/febs.13184

Sánchez-Martín, D., Sørensen, M. D., Lykkemark, S., Sanz, L., Kristensen, P., Ruoslahti, E. & Álvarez-Vallina, L. (2015). Selection strategies for anticancer antibody discovery: searching off the beaten path. Trends in Biotechnology, 33(5), 292-301. https://doi.org/10.1016/j.tibtech.2015.02.008

Sun, M., Yang, C., Zheng, J., Wang, M., Chen, M., Le, D. Q. S., Kjems, J. & Bünger, C. (2015). Enhanced efficacy of chemotherapy for breast cancer stem cells by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense. Acta Biomaterialia, 28, 171–182. https://doi.org/10.1016/j.actbio.2015.09.029

Stevenson, L., Laursen, E., Cowan, G. J., Bandoh, B., Barfod, L., Cavanagh, D. R., Andersen, G. R. & Hviid, L. (2015). α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes. P L o S Pathogens, 11(7), 1-19. [e1005022]. https://doi.org/10.1371/journal.ppat.1005022

Steinberger, M., Föller, M., Vogelgesang, S., Krautwald, M., Landsberger, M., Winkler, C. K., Kasch, J., Füchtbauer, E. M., Kuhl, D., Voelkl, J., Lang, F. & Brinkmeier, H. (2015). Lack of the serum- and glucocorticoid-inducible kinase SGK1 improves muscle force characteristics and attenuates fibrosis in dystrophic mdx mouse muscle. Pflügers Archiv - European Journal of Physiology, 1965-1974(10), 1965-1974. https://doi.org/10.1007/s00424-014-1645-5

Steffensen, L. B., Mortensen, M. B., Kjolby, M., Hagensen, M. K., Oxvig, C. & Bentzon, J. F. (2015). Disturbed Laminar Blood Flow Vastly Augments Lipoprotein Retention in the Artery Wall: A Key Mechanism Distinguishing Susceptible From Resistant Sites. Arteriosclerosis, Thrombosis, and Vascular Biology, 35, 1928-1935. https://doi.org/10.1161/ATVBAHA.115.305874

Steffensen, L. B., Poulsen, C. B., Shim, J., Bek, M., Jacobsen, K., Conover, C. A., Bentzon, J. F. & Oxvig, C. (2015). Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs. Journal of Cardiovascular Translational Research, 8(9), 528-535. https://doi.org/10.1007/s12265-015-9656-y

Staniec, D., Ksiazek, M., Thøgersen, I. B., Enghild, J. J., Sroka, A., Bryzek, D., Bogyo, M., Abrahamson, M. & Potempa, J. (2015). Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase. Journal of Biological Chemistry, 290, 27248-27260. https://doi.org/10.1074/jbc.M115.648782

Song, W., Song, X., Yang, C., Gao, S., Klausen, L. H., Zhang, Y., Dong, M. & Kjems, J. (2015). Chitosan/siRNA functionalized titanium surface via a layer-by-layer approach for in vitro sustained gene silencing and osteogenic promotion. International Journal of Nanomedicine (Online), 10, 2335-2346. https://doi.org/10.2147/IJN.S76513

Sommer, T., Bjerregaard-Andersen, K., Simensen, S. M., Jensen, J. K., Jochimsen, B., Riss, P. J., Etzerodt, M. & Morth, J. P. (2015). Enzymatic Detection and Quantification Assay of Isatin, a Putative Stress Biomarker in Blood. A C S Chemical Neuroscience, 6, 1354-1360. https://doi.org/10.1021/cn500346x

Sokol, M., Jessen, K. M. & Pedersen, F. S. (2015). Human endogenous retroviruses sustain complex and cooperative regulation of gene-containing loci and unannotated megabase-sized regions. Retrovirology, 12(32), 1-11. https://doi.org/10.1186/s12977-015-0161-9

Soggiu, A., Piras, C., Gaiarsa, S., Bendixen, E., Panitz, F., Bendixen, C., Sassera, D., Brasca, M., Bonizzi, L. & Roncada, P. (2015). Draft Genome Sequence of Clostridium tyrobutyricum Strain DIVETGP, Isolated from Cow's Milk for Grana Padano Production. Genome Announcements, 3(2), [ e00213-15]. https://doi.org/10.1128/genomeA.00213-15

Sofos, N., Xu, K., Dedic, E. & Brodersen, D. E. (2015). Cut to the chase-Regulating translation through RNA cleavage. Biochimie, 114, 10-17. https://doi.org/10.1016/j.biochi.2015.01.009

Soerensen, M., Nygaard, M., Dato, S., Stevnsner, T., Bohr, V., Christensen, K. & Christiansen, L. (2015). Association study of FOXO3A SNPs and aging phenotypes in Danish oldest-old individuals. Aging Cell, 14(1), 60-66. https://doi.org/10.1111/acel.12295