Institut for Molekylærbiologi og Genetik

Aarhus Universitets segl

Xavier Bofill de Ros

Research

MicroRNAs are a class of non-coding RNAs with essential roles in gene expression. Together, miRNAs regulate the expression of >60% of genes and deficiencies in their maturation, as well as their levels within cells, have been shown to drive several diseases including cancer. MicroRNAs are transcribed as longer transcripts, the maturation of which requires the adequate RNA folding and the precise cleavage of DROSHA and DICER1. This processing is aided by more than 180 RNA-binding proteins. The resulting products are mature microRNAs that provide specificity to Argonaute (AGO), a key component in RNA silencing.

We are interested in the following research topics:

  • Mechanisms of dysregulation of microRNA processing and function
  • Therapeutic opportunities based on small RNAs and RNA metabolism

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Peer-reviewed publications

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Rodríguez-Comas, J., Moreno-Asso, A., Moreno-Vedia, J., Martín, M., Castaño, C., Marzà-Florensa, A., Bofill-De Ros, X., Mir-Coll, J., Montané, J., Fillat, C., Gasa, R., Novials, A. & Servitja, J. M. (2017). Stress-induced microrna-708 impairs b-cell function and growth. Diabetes, 66(12), 3029-3040. https://doi.org/10.2337/db16-1569
Hong, Z. & Bofill-De Ros, X. (2024). Metabolism of tRNAs and rRNAs shape immunoactive signatures in chronic obstructive pulmonary disease and pulmonary infections. Molecular Therapy Nucleic Acids, 35(3), Artikel 102298. https://doi.org/10.1016/j.omtn.2024.102298
Hong, Z., Tesic, N. & Bofill-De Ros, X. (2025). Analysis of Processing, Post-Maturation, and By-Products of shRNA in Gene and Cell Therapy Applications. Methods and Protocols, 8(2), Artikel 38. https://doi.org/10.3390/mps8020038
Hatton, J. N., Frone, M. N., Cox, H. C., Crowley, S. B., Hiraki, S., Yokoyama, N. N., Abul-Husn, N. S., Amatruda, J. F., Anderson, M. J., Bofill-De Ros, X., Carr, A. G., Chao, E. C., Chen, K. S., Gu, S., Higgs, C., Machado, J., Ritter, D., Schultz, K. A. P., Soper, E. R. ... Stewart, D. R. (2023). Specifications of the ACMG/AMP Variant Classification Guidelines for Germline DICER1 Variant Curation. Human Mutation, 2023, Artikel 9537832. https://doi.org/10.1155/2023/9537832
Fillat, C., José, A., Bofill-de Ros, X., Mato-Berciano, A., Maliandi, M. V. & Abate-Daga, D. (2010). Controlling adenoviral replication to induce oncolytic efficacy. Open Gene Therapy Journal, 3, 15-23. https://doi.org/10.2174/1875037001003020015

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Revideret 13.11.2025
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Lisbeth Heilesen