During her PhD research, Astrid Bøgh Jensen studied the effects of antithrombin deficiency in mice. Antithrombin is a protein, which prevents the blood from improper coagulating and an Antithrombin deficiency increases the risk of developing blood clots. She furthermore attempted to produce a mouse model carrying the human antithrombin gene, using the CRISPR/Cas9 method. A relatively new and innovative method for introducing a foreign gene.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University

This résumé is prepared by the PhD student.

Time: Friday 23 January 2015 at 13.00
Place: Building 1532, Room 122, Lecture Theatre G2, Ny Munkegade 120, Aarhus University,
Title of dissertation: Generation of Humanized Mouse Models with Focus on Antithrombin Deficiency
Contact information: Astrid Bøgh Jensen e-mail: abj@mbg.au.dk
Members of the assessment committee:
Professor Branko Zevnik, CECAD In Vivo Research, University of Cologne
Associate professor Hanne Cathrine Bisgaard, Department of Cellular and Molecular Medicine, University of Copenhagen
Professor Finn Skou Pedersen, Department of Molecular Biology and Genetics, Aarhus University (chair)
Main supervisor: Professor Ernst-Martin Füchtbauer. Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
Co-supervisor: Professor Peter Andreasen, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University
Language: The PhD dissertation will be defended in English.

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.