During his PhD studies, Lasse L. Hildebrandt has conducted research on man-made nanoscale structures based on DNA. These structures can be dynamic devices and afford simple controllable functionalities. The performance of these devices is dependent on dynamic transitions between different possible conformations, and Lasse L. Hildebrandt has studied such conformational dynamics in selected DNA structures.

Conformational dynamics have been studied using the technique Föster resonance energy transfer (FRET) and additionally, Lasse L. Hildebrandt has investigated which requirements that must be met in order for this technique to produce truly quantitative results. The new research findings contribute to the understanding of opportunities and challenges of devices in DNA nanotechnology.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé is prepared by the PhD student.

Time: Friday 24 April 2015 at 13.15
Place: Building 1523, room 318, Lecture Theatre I, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000 Aarhus C
Title of dissertation: Single molecule fluorescence microscopy studies of man-made DNA nanostructures
Contact information: Lasse L. Hildebrandt, e-mail: llhildebrandt@inano.au.dk, tel.: +45 2972 4114
Members of the assessment committee:
Professor Friedrich Simmel, Physics Department, Technische Universität München, Germany
Associate Professor Marcus Wilhelmsson, Chemistry and Chemical Engineering, Chalmers, Sweden
Senior Researcher Morten Foss (chair), iNANO, Aarhus University
Main supervisor:
Professor Jørgen Kjems, iNANO and Department of Molecular Biology and Genetics, Aarhus University
Co-supervisor:
Associate Professor Victoria Birkedal, iNANO, Aarhus University
Language: The PhD dissertation will be defended in English.

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.