During her PhD studies, Yan Yan researched extracellular microRNAs, which are cell-free and can circulate in bodily fluids. Yan Yan studied the expression profile of extracellular microRNAs using Next generation sequencing to show the dysregulation of microRNA expression in oral cancer and rheumatoid arthritis, and differential expression of microRNAs during osteogenic differentiation of mesenchymal stem cells.

The new research findings contribute to the understanding of extracellular microRNA in human diseases and stem cell differentiation.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Wednesday, 28 September 2016 at 13.15.
Place: Building 1531, room 219, Lecture Theatre D4, Department of Mathematics, Ny Munkegade 118, Aarhus University, 8000 Aarhus C.
Title of dissertation: Investigation of extracellular microRNAs in oral squamous cell carcinoma, rheumatoid arthritis and mesenchymal stem cell differentiation
Contact information: Yan Yan, e-mail: yanyan@inano.au.dk, tel.: +45 9195 9154
Members of the assessment committee:
Senior Researcher Maria Mittelbrunn Herrero, Molecular Biology, Immunology, Human Biology, Hospitaol 12 de Octubre, Madrid, Spain
Senior Researcher Malene Møller Jørgensen, Klinik Diagnostik, Aalborg University Hospital
Associate Professor Ken Howard (chair), iNANO, Aarhus University
Main supervisor:
Professor Jørgen Kjems, iNANO and Department of Molecular Biology and Genetics, Aarhus University
Co-supervisor:
Associate Professor Shan Gao, iNANO, Aarhus University
Language: The PhD dissertation will be defended in English

The defence is public.

The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520, rooms 128-134, 8000 Aarhus C.