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News

Förster resonance energy transfer (FRET) combines laser light and ultra-sensitive cameras that send signals into an individual molecule. This signal spreads to the other colour molecule on the pump, which begins to transmit light of another colour. The group focuses on the relationship between the different colours, which is registered in a specially built light microscope. These measurements provide information about the pump’s movements. (Photo: Mateusz Dyla)
Illustrated here is the timeline for the pump function, which is now revealed in high time resolution. The curve shows the relationship between the measured fluorescent colours emitted from dyes bound to the pump. At left, the pump is open towards the interior of the cell and has bound calcium ions and absorbed the ATP molecule – in other words, it is ‘charged’. The next step is the new, key result: in the red field, the pump is in the previously unknown closed state, where it has enclosed the ions to be sent out of the cell. The final stage illustrated shows that the pump has opened and released calcium ions into the surroundings. From here, it cannot return to the highlighted state. (Illustration: Daniel Terry/Dyla)

2017.11.09 | Research

The end of ‘Pump Fiction’

Our cells are capable of moving energy and material around to the places where they are required, and ensuring that the body works properly. But how do the cells do this in real time from the perspective of the individual molecule? A Danish research team has succeeded in revealing basic insights into this previously unknown world by carrying out…

2017.10.11 | Research

Molecular Velcro helps to assemble functional nuclear pore complexes

An international research team now explains how one of the largest molecular machineries - the nuclear pore complex – is being assembled using natively unfolded FG-repeats as molecular Velcro.

2017.10.12 | Research

Why do physicists blur their images before showing them to biologists?

How can cartoon images aid in understanding bacterial biological processes? How did Hollywood contribute to quantum physics? How do aesthetics, art, and design influence scientific visualization and vice versa? These are just some of the questions that a new book raises. Bjørn Panyella Pedersen, Ebbe Sloth Andersen and Ditte Høyer Engholm from…

2017.10.02 | Research

Llama-derived nanobodies as a new tool in solving crystal structure

Aarhus University scientists have developed miniature antibodies (nanobodies) that can be labelled on certain amino acids. This provides a direct route for solving new X-ray crystal structures of protein complexes important for gaining mechanistic understanding of cellular processes, which is important in the development of drugs.

Elevated levels of the bad LDL cholesterol increases the risk of premature death from a blood clot in the heart, so there is a great need for medicine which helps the body to remove it from the blood.

2017.09.26 | Research

Danish discovery can pave the way for more effective cholesterol medicine

Research from Aarhus University sheds new light on how the body converts the bad kind of cholesterol. The discovery could lead to new and potentially more effective medicine.

The researchers used  two populations of Holstein cows from Nordic countries and China and have identified several genetic variants associated with the fertility of the cows. Photo: Colourbox.

2017.09.12 | Research

Improved solution to increase fertility in high-yielding cows

Through decades, researchers have been able to increase milk production in cows by intense genetic selection. However, this has resulted in a reversal of the fertility of the cows. This has led the researchers to find an optimum solution.

2017.09.11 | Research

Chromosomal deletion catalogue in dairy cattle facilitates the identification of lethal mutations

Genetic mutations are responsible for a substantial yearly-economic loss in the dairy industry. Mapping of such variants is essential for effective breeding planning and performance improvement.

Peter Aasted Paulsen. Photo: Lisbeth Heilesen.

2017.09.04 | Grant

Peter Aasted Paulsen receives a donation at a ceremony in Copenhagen to study T-cell virus complex

On Friday, Peter Aasted Paulsen received a donation of DKK 100,000 at a ceremony at Rigshospitalet from Savværkejer Jeppe Juhl og Hustru Ovita Juhls Mindelegat to study sugar transport and their complexes.

Ditlev E. Brodersen. Photo: Tamo Meijburg.

2017.08.28 | Awards

Ditlev E. Brodersen receives ST Education Award

The ST Education Award 2017 goes to Associate Professor Ditlev Egeskov Brodersen for his contribution to increasing the quality of teaching at ST, not only through his own engaging teaching style, but also for developing a new tool that is available to all teachers.

Mogens Sandø Lund. Photo: Tamo Meijburg.

2017.08.28 | Awards, Knowledge exchange

Mogens Sandø Lund receives ST Industrial Collaboration Award

The ST Industrial Collaboration Award 2017 goes to Professor Mogens Sandø Lund, Department of Molecular Biology and Genetics, for his long-standing efforts and considerable influence on business collaboration regarding refinement and breeding in Denmark.

A Danish-American research team has now found another piece of the puzzle for the development of personalized medicine with the results of a highly sensitive monitoring of cancer-related topoisomerase II enzymes.

2017.08.23 | Research

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity

The development of DNA sensor systems is of great importance for advances in medical science. Now another piece of the puzzle for the development of personalized medicine has been found with the results of a highly sensitive monitoring of cancer-related topoisomerase II enzymes.

Ian Max Møller

2017.08.09 | Awards

Ian Max Møller receives ASPB award

Ian Max Møller has received the Corresponding Membership Award of the American Society of Plant Biologists (ASPB).

Associate Professor Ken Howard, head of the NanoPharmaceutical Lab at the Interdisciplinary Nanoscience Center / Department of Molecular Biology and Genetics.

2017.07.06 | Research, Knowledge exchange

Researchers define together with industry the intracellular recycling pathway of human serum albumin

Collaborative work between the NanoPharmaceutical Lab at the Interdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics and the Novozymes owned company Albumedix have uncovered a neonatal Fc receptor (FcRn)-dependent endosomal cellular sorting pathway. This has great importance in describing fundamental mechanisms…

Photo: Jette Odgaard Villemoes

2017.07.03 | Grant, Knowledge exchange

Researchers from MBG participate in a large EU project on future genomic management tools for European cattle production

Researchers from Center for Quantitative Genetics and Genomics at the Department for Molecular Biology and Genetics, Aarhus University in Foulum, are participating in the GenTORE project, launched in Paris 22–23 June 2017.

2017.06.27 | Research

New knowledge about the dynamics of proteins can shape the future in drug development

New research provides mechanistic insight into how protein dynamics control the activity of a group of enzymes called serine proteases. As serine proteases play pivotal roles in blood coagulation, the innate immune system and tissue remodeling, the results may be important for the development of new drugs for the treatment of various diseases.

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