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As the first in the world, a group of researchers at Aarhus University has made a comprehensive description of the proteins in the venom. Photo: Simon Bomholt – gilamonsters.dk.

2015.02.24 | Research

Mapping lizard venom facilitates drug development

Lizards and other reptiles are not normally considered venomous, but a number of lizard species actually do produce and use venom. The most classic venomous lizard is no doubt the gila monster – a heavy-bodied lizard. As the first in the world, a group of researchers at Aarhus University has made a comprehensive description of the proteins in the…

The mouse to the left produces a high level of the protein stanniocalcin-2 and is therefore much smaller than the normal-sized mouse to the right (Photo: Malene Rune Jepsen).
Pictured at right is a transgenic mouse, which artificially produces a high level of stanniocalcin-2 and therefore demonstrates strongly reduced growth compared with the normal mouse at left – from the same litter. Growth factors called IGF signal cells that they should divide by binding to receptors on the surface of the cell. The signalling is precisely controlled by IGF inhibitors, which can prevent the IGF from binding with its receptor. However, the signalling can take place at the cellular surface, where the PAPP-A enzyme is present. PAPP-A cleaves the IGF inhibitor, thus actively releasing IGF, which triggers the signalling inside the cell. The presence of stanniocalcin-2 (right half of the figure) causes inactivation of PAPP-A – and thereby prevents indirect signalling, cell division and growth (Photo: Malene Rune Jepsen).

2015.02.20 | Research

Protein found to be the cause of small growth

The stanniocalcin-2 protein is very important for cellular growth, and a team of researchers has now discovered how it works. This could be significant for understanding growth in tissue such as cancer cells.

Hanne Poulsen has been awarded a Lundbeck Foundation Fellowship valued at DKK 10 million for a five-year research project (Photo: Lundbeckfonden)
It is necessary for all cells in the human body that the sodium-potassium pump works as it should. The pump is a complex and fascinating machine that works from its position in the cell membrane to ensure the right balance between sodium and potassium ions in the intracellular and extracellular environments (Figure: Hanne Poulsen)

2015.02.05 | Grant

Ion pumps in cells and their importance for nervous disorders

More knowledge about cellular ion pumps will pave the way for improved treatment of neurological disorders. Molecular Biologist Hanne Poulsen has just been awarded a Lundbeck Foundation Fellowship valued at DKK 10 million for a five-year research project.

Researchers from Aarhus University will develop dairy cattle breeds that are specially suited to organic production. Photo: Janne Hansen

2015.01.26 | Grant

Breeding for organic dairy production

A new project is set to benefit organic dairy production, partly by developing breeds of cows that are better suited to organic production and partly by creating niche dairy products based on knowledge of the cows' breeding characteristics.

2015.01.15 | Grant

Molecular Biology and Genetics researchers awarded considerable strategic funds

In the latest appropriation round, researchers at the Department of Molecular Biology and Genetics were awarded no fewer than three out of ten grants by the Programme Committee for Health, Food and Welfare under the Danish Council for Strategic Research (DSF).

Assistant Professor Stig Uggerhøj Andersen was awarded a grant of DKK 17 million from the Innovation Fund Denmark to increase the amount of nitrogen in organic farming. Photo: Lisbeth Heilesen.
The researchers will study the correlation between clover yields and the genetic composition of the three components of the nitrogen cycle – soil bacteria, clover and grass. Photo: Colourbox.

2015.01.15 | Grant

Enough nitrogen for organic farming

One of the major challenges in organic farming is maintaining a positive balance in the nitrogen cycle. Nitrogen is an important nutrient for plants, but it is removed from the soil whenever crops are harvested. It can therefore be difficult to maintain a sufficiently high level of accessible nitrogen in the soil without using artificial…

Associate Professor Henrik Brinch-Pedersen has been awarded a grant of DKK 12.3 million by the Innovation Fund Denmark to develop natural food colouring. Photo: Charlotte Hamann Knudsen.
To meet the increasing demand for natural food colours, the research team intends to increase the content of the natural colorant anthocyanin in black carrots. Photo: Bjarne Jørnsgaard, Chr Hansen.

2015.01.15 | Grant

Developing natural food colouring

A number of synthetic food colours have been shown to have undesirable side effects, especially in children. Since 2010, the EU has demanded that selected synthetic dyes should be labelled, and there is a major world demand for natural food colours. Associate Professor Henrik Brinch-Pedersen has been awarded a grant of DKK 12.3 million by the…

Anders Olsen has been awarded DKK 10 million from the Innovation Fund Denmark to find out why some bacteria are healthy and some harmful. Photo: Lisbeth Heilesen.
The researchers use the simple and popular nematode (roundworm) <em>C. elegans</em> in their studies. Because it is so small (1.2 mm) and has a short generation time (3 days), it is extremely well suited to this type of study. Photo: Anders Olsen.

2015.01.15 | Grant

Worms and health-promoting bacteria

A research collaboration between Aarhus University, SSI (State Serum Institute) and DuPont will find out why some bacteria are healthy and some harmful. A worm measuring 1.2 mm that feeds on bacteria will help provide the answers. The Innovation Fund Denmark has invested in the project by awarding a grant of DKK 10 million to Anders Olsen.

The co-occurrence of the NEXT complex and an accessible RNA 3’end drives an early RNA exosome decay. The NEXT complex, via its RNA-binding component RBM7, physically contacts RNAs early during their cellular lifecycle (1). NEXT binding does not automatically lead to decay by the exosome (2a), but the presence of NEXT provides the possibility for exosomal degradation, which can only occur upon emergence of an unprotected RNA 3’end (2b). One group of newly discovered NEXT substrates are metabolites of intronic snoRNA production events (3).

2015.01.08 | Research

How to target the RNA decay machinery

In collaboration with two other European groups, researchers from Aarhus University have uncovered molecular details leading to targetting of the major RNA decay machinery, the RNA exosome, to its nuclear RNA substrates. Studies can now be designed to address the role of this early nuclear RNA decay pathway in processes where rapid RNA decay may…

By sequencing the genome of the bowhead whale, an international research team with Danish participation has identified a number of genes that may protect the whale against age-related diseases and cancer. Photo: Adam Schmedes.
Photos from the researchers' scientific article on the front page of the prestigious journal <em>Cell Reports</em>. http://www.cell.com/cell-reports/issue?pii=S2211-1247%2814%29X0026-4

2015.01.07 | Research

The genome of the bowhead whale sequenced

By sequencing the genome of the bowhead whale, an international research team with Danish participation has identified a number of genes that may protect the whale against age-related diseases and cancer.

PhD student Ewa Terczynska-Dyla and Associate Professor Rune Hartmann show new research results which suggest that it is possible to develop new treatment for hepatitis targetting the individual patient. Photo: Lisbeth Heilesen.

2015.01.05 | Research

Genes show the way to better treatment of hepatitis C

One of the most common causes of hepatitis C (formerly known as infectious hepatitis) is a hepatitis C virus infection in the liver. The disease can be treated, but not all patients are cured by the treatment currently available. New research shows that the response to medical treatment depends on genetic factors.

Bjørn Panyella Pedersen. Photo: Lisbeth Heilesen

2014.12.16 | Grant

ERC Starting Grant awarded to Bjørn Panyella Pedersen

Bjørn Panyella Pedersen, Department of Molecular Biology and Genetics, has been awarded a prestigious ERC Starting Grant from the European Research Council (ERC) valued at EUR 1.5 million to start a research group within structural biology at Aarhus University.

Ian Max Møller

2014.12.16 | Grant

Control of protein degradation in biology and medicine

Protein aggregation in cells is a symptom of many diseases. Ian Max Møller, Department of Molecular Biology and Genetics, will try to solve this problem during the next three years with a grant amounting to more than DKK 6.4 million from the Danish Council for Independent Research | Technology and Production Sciences.

Peter Refsing Andersen (left) and Torben Heick Jensen. Photo: Lisbeth Heilesen.

2014.11.20 | Research

A novel strategy to sort functional from non-functional RNA

The human genome is promiscuously transcribed yielding RNA from >75% of its DNA. It is presently intensely debated how much of this material is functional. Danish researchers have devised a method to help address this problem.

The strange plant Welwitschia mirabilis, which grows in the deserts of Namibia, is a veritable Methuselah with leaves that are 2-3 meters long. Now, researchers from Aarhus University will use the long-lived plant as a model for aging in humans. Photo: Janne Hansen.

2014.11.19 | Grant

Unlocking the secrets of Methuselah?

Some organisms can live for thousands of years, while we humans may achieve at the most 100-120 years. Researchers are delving into the cells of plants and humans to explore what it is that makes the difference.

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Revised 2015.02.25

How to find the Department of Molecular Biology and Genetics

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Addresses

The Department of Molecular Biology and Genetics (MBG)
is located at five different addresses:

  • The Science Park - Gustav Wieds Vej 10, 8000 Aarhus C, Denmark
  • Biokæden (Campus) - C.F. Møllers Allé 3, 8000 Aarhus C, Denmark
  • iNANO - Gustav Wieds Vej 14, 8000 Aarhus C, Denmark
  • Foulum - Blichers Allé 20, 8830 Tjele, Denmark
  • Flakkebjerg - Forsøgsvej 1, 4200 Slagelse, Denmark

More information on how to find these places and who works where


Contact information

at the Department of Molecular Biology and Genetics

E-mail: mbg@au.dk
Tel.: +45 8715 0000
CVR-no.: 31119103
VAT ("moms") number: 31 11 91 03
EAN-no. 5798000419964
"Stedkode" (departmental id number): 2802


Internal information

For staff and students at
the Department of Molecular Biology and Genetics

Aarhus University
Nordre Ringgade 1
DK-8000 Aarhus C

Email: au@au.dk
Tel: +45 8715 0000
Fax: +45 8715 0201

CVR no: 31119103

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