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RNA regulation is crucial for embryonic stem cell differentiation



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With a grant from the Independent Research Fund Denmark’s Sapere Aude programme, Peter Refsing Andersen from the Department of Molecular Biology and Genetics and AIAS, Aarhus University, will uncover the strategies used by DNA parasites to evade the genomic defence mechanisms. Photo: Lisbeth Heilesen

2019.11.19 | Grant

Revealing how genes fight each other for space in the genome

Spread of DNA parasites can destroy important genes, so all forms of life have evolved genome defence mechanisms to keep the parasites in check. With a grant of DKK 6.2 mio. from the Independent Research Fund Denmark’s Sapere Aude programme, Peter Refsing Andersen from the Department of Molecular Biology and Genetics and AIAS, Aarhus University,…

A functional link between nuclear RNA decay and transcriptional control by the Polycomb Repressive Complex 2. In the absence of PAXT-mediated RNA decay, nuclear pA+ transcripts are stabilised. Excess RNA binds and out-titrates PRC2 from chromatin, and the interaction between complex subunits is disrupted. Normal PRC2-repressed loci show decreased H3K27me3 levels and correlates with increased an increase in transcription. Figure: Will Garland/AU

2019.11.15 | Research

RNA regulation is crucial for embryonic stem cell differentiation

Nuclear RNA levels are kept in check by RNA decay factors. Now, researchers at Aarhus and Copenhagen Universities show that an excess of RNA in the nucleus can have negative effects on a crucial regulator of stem cell differentiation.

Bjørn Panyella Pedersen. Photo: AU Photo

2019.11.13 | People

Bjørn Panyella Pedersen selected as EMBO Young Investigator

MBG Group Leader Bjørn Panyella Pedersen is one of 27 researchers that have been selected to join the Young Investigators Programme of the European Molecular Biology Organization (EMBO) in 2019. For the coming four years, he will join this prestigious network of young scientists.