A Channel in the Heart of the Matter



News

Figure caption: Left: Unsharpened (transparent light blue) and sharpened (solid) cryo-EM density maps of human TRPM4 in nanodiscs as viewed from the side. The ion channel is composed by four domains which are colored in each their solid color. Middle: Ribbon diagram of human TRPM4. A calcium binding site belonging to one of the monomers is marked with a box. Right: A zoom-in on the calcium binding site with the coordinating residues represented by sticks and their helices in ribbons. The ribbon diagram is overlaid with the densities of the calcium structure (gray mesh) and the difference density (blue mesh) between the calcium-bound structure and the calcium-free structure. Figure: Henriette Autzen.
Henriette Elisabeth Autzen, who is employed as a postdoc at the Department of Molecular Biology and Genetics at Aarhus University in Denmark, is stationed at the University of California, San Francisco, USA, where she and her American colleagues have published their determination of two structures of the human calcium-activated cation channel, TRPM4, in <em>Science</em>. Photo: University of California, San Francisco.

2017.12.15 | Research

A Channel in the Heart of the Matter

How cells control the movement of ions, electrically charged species, in and out of the cell is a grand puzzle, whose completion will allow a thorough fundamental understanding of human physiology. A Danish-American team of researchers has found a piece of the puzzle with their determination of two structures of the human calcium-activated cation…

Bill Gates (on the right side of the table, in the middle) listening to the researcher’s plans for their research. The head of the project from Aarhus University, Professor Jens Stougaard, is seen on the left side of the table, 2nd from the left. Photo: ©Bill & Melinda Gates Foundation/Alain Brin.

2017.12.11 | Research

Bill Gates met with researchers from Aarhus University

Bill Gates recently met with researchers from the Department of Molecular Biology and Genetics at Aarhus University to discuss the sustainable use of biological nitrogen fixation that allows legumes to use atmospheric dinitrogen as a nitrogen source.

Suresh Rattan

2017.11.30 | People

Suresh Rattan conferred an honorary professorship in Poland

Suresh Rattan Ph.D., Dr.scient. has been awarded an honorary professorship at the University of Rzeszów in Poland.

Adult fish in the zebrafish facility at the Department of Molecular Biology and Genetics, AU. Photo: Lisbeth Heilesen.
Comparison of ECG traces from humans and from two-day old zebrafish. The zebrafish ECG shows the same characteristics as the human ECG, making it possible to measure the QT interval. The blue trace represents a normal zebrafish ECG, the red trace displays short QT. Figure: Vladimir Matchkov and Christian Aalkjær.

2017.11.26 | Research

Zebrafish used to identify disease mechanism for heart disease

In a large collaborative study between the Department of Clinical Medicine, the Department of Biomedicine, and the Department of Molecular Biology and Genetics, among others, the researchers have succeeded in identifying and characterising the consequences of a newly discovered mutation associated with cardiac arrhythmia.

Events

Mon 18 Dec
14:15-15:00 | iNANO AUD (1593-012), Gustav Wieds Vej 14
Inaugural Lecture: Duncan Sutherland
Tue 19 Dec
09:00-11:00 | Auditorium, Aarhus University Foulum, Blichers Allé 20, 8830 Tjele
PhD defence: Qianqian Zhang: Towards Cattle Precision Breeding Using Next Generation Sequencing
Qianqian Zhang.
Tue 19 Dec
13:00-15:00 | Building 1421, Meeting Room 2, AU Conference Centre, Aarhus University Fredrik Nielsens Vej 4, Aarhus C
PhD defence: Estrella Elvira-Ramirez: The Role of Lotus Japonicus Ethylene Receptors During Root Nodule Symbiosis – Identifying New Symbiotic Regulators
Estrella Elvira-Ramirez
Tue 16 Jan
13:00-15:00 | Nobel Auditorium, Building 1482–105 i Nobelparken
Information meeting about the calls from "Innovationsfonden" 2018
At the meeting you will be able to hear about the foundation's support schemes and receive the latest news about the proposals in 2018. There will also be an opportunity to ask questions to representatives from the Innovation Fund. The meeting is in English. Registration is not required. From 13-14:

PhD defences

Jeryl Cheng

2018.01.18 | Talent development

Jeryl Cheng: The role of LysM Receptor-like kinases in Lotus japonicus: Are you my Friend or Foe?

PhD defence, Thursday 18 January 2018. Jeryl Cheng.

Estrella Elvira-Ramirez

2017.12.19 | Talent development

Estrella Elvira-Ramirez: The Role of Lotus Japonicus Ethylene Receptors During Root Nodule Symbiosis – Identifying New Symbiotic Regulators

PhD defence, Tuesday 19 December 2017, Estrella Elvira-Ramirez.

Qianqian Zhang

2017.12.19 | Talent development

Qianqian Zhang: Towards Cattle Precision Breeding Using Next Generation Sequencing

PhD defence, Tuesday 19 December 2017, Qianqian Zhang.