New nuclear RNA retention activity discovered



News

Figure. A functional competition between RNA export factor AlyREF and the RNA exosome adaptor protein ZFC3H1 determines the fate of polyadenylated RNA. Shortly after RNA transcription starts, the nascent RNA is bound by the cap-binding proteins, CBP20 and CBP80. ARS2 directly interacts with CBP20/CBP80 to bridge interactions with several different complexes that determine RNA fate. (Left panel of the figure). Polyadenylated RNAs, like most mRNAs, are exported from the nucleus to the cytoplasm in a process involving the export factor AlyREF, which interacts with CBP20/CBP80 to recruit the export machinery. (Right panel of the figure). ZFC3H1 acts as a central factor in retention and degradation of polyadenylated RNA. This prevents unwanted RNAs from entering the cytoplasm where they could potentially cause a global translation collapse. Figure: Toomas Silla.

2018.05.16 | Research

New nuclear RNA retention activity discovered

Gene expression involves mRNA transport from its place of synthesis to the cytoplasm where protein translation occurs. However, many non-coding RNA species do not follow this flow and new data now demonstrate how cells prevent the unwanted export of RNA and instead ensure nuclear degradation.

The long non-coding RNA called A-ROD functions as a lasso to recruit proteins to the DKK1 gene. Figure Figure: Evgenia Ntini

2018.04.24 | Research

A non-coding RNA lasso catches proteins in breast cancer cells

A Danish-German research team has shown that not only the where and when of long non-coding RNA expression is important for their function but also the how. The results can have a big impact on our understanding of dynamic regulation of gene expression in biological processes.

Ditlev E. Brodersen receives DKK 10 mio. from the Novo Nordisk Foundation to study how microorganisms defend themselves. The research will be of great importance for the treatment of infectious diseases in the future. Photo: Lars Kruse, AU-foto.

2018.04.04 | Grant

Ditlev E. Brodersen is among the first to be appointed Novo Nordisk Foundation Hallas-Møller Ascending Investigator

As one of the first researchers in the country, Associate Professor Ditlev E. Brodersen receives the Hallas-Møller Ascending Investigator grant as part of the Novo Nordisk Foundation Research Leader Programme. The 10 mio DKK (ca. Euro 1,342,320) grant will provide Ditlev Brodersen's research lab with opportunities to explore the survival…

Postdoc Peter Refsing Andersen has been awarded a Hallas-Møller Emerging Investigator grant of DKK 10 mio. over the next five years to establish a research group at the Department of Molecular Biology and Genetics, AU, to study genetic parasites. Photo: Ernst Tobisch.

2018.04.04 | Grant

Peter Refsing Andersen awarded the Hallas-Møller Emerging Investigator grant

Postdoc Peter Refsing Andersen from the Institute of Molecular Biotechnology (IMBA) at Vienna BioCenter in Austria has been awarded a Hallas-Møller Emerging Investigator grant of DKK 10 mio. (ca. Euro 1,342,320) over the next five years to establish a research group at the Department of Molecular Biology and Genetics, AU, to study genetic…

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PhD defences

Cecilie Kirkeby Skeby

2018.06.13 | Talent development

Cecilie Kirkeby Skeby: Understanding Diabetes Mellitus through circular RNAs

PhD defence, Wednesday 13 June 2018, Cecilie Kirkeby Skeby.

Ewa Molska

2018.04.10 | PhD defense

Ewa Molska: Diverse RNA classes use common maturation pathways

PhD defense, Tuesday 10 April 2018 Ewa Molska