Generation of complex gene architectures in the human genome

News

2016.08.23 | People

Poul Nissen awarded the Order of Dannebrog

Her Majesty the Queen has awarded Professor Poul Nissen the Order of Dannebrog as of 23 August 2016.

A variant of the FUT1 gene has been shown to be able to protect pigs' intestines against E. coli. This knowledge may be used proactively in the efforts to cut back on antibiotics. Photo: Janne Hansen.

2016.08.18 | Research

Gene variant in pigs may open up for less use of antibiotics

A variant of the FUT1 gene has been shown to be able to protect pigs' intestines against E. coli. This knowledge may be used proactively in the efforts to cut back on antibiotics.

1) Gene promoters that are far away from other genes typically produce transcripts on both strands. The PROMoter uPstream Transcript (PROMPT) is short and rapidly degraded due to special DNA sequence patterns around the PROMPT and which are not present at the gene start site. Thus, the gene product is typically a stable mRNA.   2) If two gene start sites share a common promoter, no PROMPTs are produced. Both genes start sites produce stable RNAs.  3) If two gene promoters are closely positioned, PROMPTs are produced, but are stabilized because the DNA signals necessary for their degradation cannot form because the gene promoters are too close. Instead, the PROMPTs grow longer and are stable, which in effect creates longer mRNA variants from the two gene start sites.  4) If gene promoters are sufficiently separated, their DNA patterns do not influence their neighboring PROMPTs, which remain short and unstable, much like in the first case above.

2016.08.15 | Research

Generation of complex gene architectures in the human genome

Intense investigations during the past 10-15 years have revealed that the human genome is transcribed in a manner that is much more complicated than previously appreciated. A collaboration between researchers from Aarhus and Copenhagen now reveals some underlying principles leading to such promiscuous genome activity.

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PhD defences

[Translate to English:] Janus Asbjørn Schatz-Jakobsen

2016.09.16 | Talent development

Janus Asbjørn Schatz-Jakobsen: Structural insight into the inhibition of the terminal pathway of the complement system

PhD defence, Friday 16 September 2016. Janus Asbjørn Schatz-Jakobsen.

Kinga Winczura

2016.09.01 | Talent development

Kinga Winczura: The role of zinc finger protein ZC3H18 and its interacting proteins in RNA fate decisions

PhD defence, Thursday 1 September 2016. Kinga Winczura.

Iben Boutrup Kongsfelt

2016.08.31 | Talent development

Iben Boutrup Kongsfelt: Bone formation and cell proliferation are affected by the expression of phosphate transporters PiT1 and PiT2

PhD defence, Wednesday 31 August 2016. Iben Boutrup Kongsfelt.

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