Transport of molecular motors into cilia


News

The picture at the top shows a sperm cell with the head (cell body) and tail (also known as flagellum or cilium) that propels the sperm cell forward. The schematic in the middle shows how dynein motors (yellow stars) are transported via intraflagelar transport (IFT) and periodically distributed. The picture at the bottom illustrates how the ODA16 structure functions as an adaptor between the transport system and the dynein motors.

2017.03.27 | Research

Transport of molecular motors into cilia

Molecular motors produce the force that powers the beat of sperm cell tails to generate movement toward the egg cell for fertilization. New research now shows how the molecular motors that power the movement of sperm cells are recognized and specifically transported into the tail region of the cell. This knowledge can pave the way for a better…

The RedHill team assembled in Denmark. From left to right: Terry F. Plasse (MD, Medical Director, ReHill Biopharma), Danielle T. Abramson (Ph.D., Director, Intellectual Property and Research, RedHill Biopharma), Mark L. Levitt, (MD, Ph.D., Medical Director, Oncology, RedHill Biopharma), Emil Oldenburg (M.Sc., Scientific Assistant, Aarhus University), Christine R. Schar (Ph.D., Postdoctoral Fellow, Aarhus University) and Jan K. Jensen (Ph.D., Project Manager, Aarhus University).

2017.03.23 | Grant

Danish researchers and Israeli biopharmaceutical company collaborate to develop anti-cancer drugs

The Israeli Biopharmaceutical company RedHill Biopharma Ltd. (NASDAQ: RDHL) (Tel-Aviv Stock Exchange: RDHL) has extended its collaboration with researchers at Aarhus University in order to develop a potentially promising drug candidate for cancer treatment. The drug candidate is based on a protease inhibitor molecule - an area the Danish…

Model for monitoring and repairing damaged DNA (left figure). The crystal structure of the DNA control protein Rad26 that is responsible for bringing the Rad3 kinase to damaged DNA and starting repair signalling (right figure).

2017.03.20 | Research

Structural knowledge of the DNA repair complex

New Danish research provides mechanistic insight into how DNA is monitored and repaired if damage occurs. The results may eventually help to improve the treatment of certain types of cancer, as the DNA repair complex provides a mechanism for cancer cells to resist chemotherapy.

Model for RNA fate decisions: Early during its production by PolII, the CBC-bound cap of the emerging RNA is contacted by ‘productive’ (PHAX) and ‘destructive’ (ZC3H18) factors. These proteins form mutually exclusive complexes with the CBC until a ‘decision point’ (e.g. a terminator) is encountered by PolII, after which RNA fate is determined by stable interaction with either PHAX or ZC3H18.

2017.03.15 | Research

Sorting RNA for production or decay

Our genomes are promiscuously transcribed into RNA. How cells manage to sort this massive genomic output into functional and non-functional material has remained enigmatic. New research describes protein interactions involved in such RNA fate determination.

Events

Thu 30 Mar
13:00-15:00 | Universitetshospital Skejby: AUH lokale 33, indgang D3
MSc exam ("specialeforsvar"): Mitochondrial Dysfunction in Chronic Fatigue Syndrome
Ulla Heltborg Kristensen
Thu 30 Mar
13:15-15:15 | 1590-213, iNano House, Gustav Wieds Vej 14
Qualifying exam: Molecular basis of parkinson's disease: The fate of cytotoxic oligomers under cell-like conditions
Anne Louise Hemdrup
Thu 06 Apr
13:00-15:00 | 5510-103, Big Lecture Theatre, INCUBA Science Park, Kathrinebjerg, Aarhus University, Åbogade 15, 8200 Aarhus V
Qualifying exam: Characterization of a zebrafish model for MBP mRNA regulation & identification of novel factors involved in the regulation of myelination
Jes Steengaard
Tue 11 Apr
13:00-15:00 | 1170-440, Library, Aarhus University, Ole Worms Allé 3
Qualifying exam: Analysis of dynamic choice behavior in mice
Juliane Martin

PhD defences

Jens Kvist Madsen

2017.02.24 | Talent development

Jens Kvist Madsen: Protein-surfactant interactions in industrial applications

PhD defence, Friday, 24 February 2017. Jens Kvist Madsen.

Hans Christian Høiberg

2017.02.21 | Talent development

Hans Christian Høiberg: Nucleic acids nanodrugs - are we there yet?

PhD defence, Tuesday, 21 February 2017, Hans Christian Høiberg

The Festival of Research 2017

Thursday 27 April 2017 at 14-18

See the programme for Aarhus University

Career day for students at MBG

The Department of Molecular Biology and Genetics invites all students at the department to a career day on

Friday 5 May 2017 at 14:00-ca. 16:30

at the Department of Mathematics, 1533-103, Aud. E

The speakers are all former Master students from the department representing different career paths. The event will include descriptions of the path their jobs, examples of everyday job situations and tasks, and how they use their education in their respective jobs.

More information - and registration (in Danish)

Project day for Bachelor and Master student

The Department of Molecular Biology and Genetics holds a "Project Day" where researchers from the department will present projects for Bachelor and Master students on:

  • Wednesday 24 May 2017 at 14-16

in the old canteen at pavillion by the Science Park, Gustav Wieds Vej 10 (building 3140).

Seminar series at MBG