Chuanxu Yang: Design of Nanoscale Delivery System for RNAi therapeutics
PhD defence, Monday, 3 November, Chuanxu Yang
During his PhD studies, Chuanxu Yang researched nanoscale vesicles for delivery of RNA interference (RNAi) therapeutics. RNAi, a post-transcriptional gene silencing process triggered by double-strand DNA, including synthetic short interfering RNA (siRNA) and endogenous microRNA (miRNA). RNAi has attracted great attention for developing new therapeutics, due to its capability to specifically inhibit the expression of any gene with high efficiency, including the “undruggable” diseases-associated targets.
A key challenge to achieve the therapeutic potential of RNAi therapy is the development of safe and effective delivery system to protect these short interfering RNA (siRNA) and transport them to the action site in the target cells. Chuanxu Yang designed various nanocarriers including polyplex, liposomes and theranostics and investigated their potential biomedical applications.
The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.
Time: Monday, 3 November 2014 at 13.15
Place: 1532-116, Lecture Theatre G1, Department of Mathematics, Aarhus University
Title of dissertation: Nanoparticle-Based Delivery System for Biomedical Applications of RNAi
Contact information: Chuanxu Yang, e-mail: chuanxuyang@inano.au.dk, tel.: +45 5261 8813
Members of the assessment committee:
Associate Professor, Dr. R. M. (Ray) Schiffelers, University Medical Center Utrecht, Department of Clinical Chemistry and Haematology, Utrecht, the Netherlands
Associate Professor Camilla Foged, Biomacromolecular Drug Delivery, Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen
Senior Researcher Morten Foss (chair), iNANO, Aarhus University
Main supervisor:
Professor Jørgen Kjems, iNANO and Department of Molecular Biology and Genetics, Aarhus University
Language: The PhD dissertation will be defended in English.
The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.