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Latest peer-reviewed publications at MBG

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Astono, J., Jørgensen, A. G., Bus, C., Nielsen, S. D. H., Kjems, J. & Sundekilde, U. K. (2026). Global protein profiling of human milk using pre-enriched RNA-sequence libraries. Scientific Reports, 16(1), Article 11827. https://doi.org/10.1038/s41598-026-41374-w

Aagaard, J. B., Gandini, R., Ballegaard, A.-S. R., Krogstrup Jensen, B., Dorn, B., Verner, A., Lenstrup, A., Sønderholm, M., Miehe, M., Pfützner, W., Jakob, T., Andersen, G. R., Möbs, C. & Spillner, E. (2026). Nanobody-based IgG simultaneously inhibit the allergenic and enzymatic activity of the dominant honeybee venom allergen. Nature Communications, 17(1), Article 1814. https://doi.org/10.1038/s41467-026-69572-0

Bicer, D., Matsuoka, R., Moumbock, A. F. A., Sukumar, P., Suades, A., Cheruvara, H., Quigley, A., Drew, D., Pardon, E., Steyaert, J., Henderson, P. J. F., Caffrey, M., Griese, J. J. & Nji, E. (2026). Structural basis of specific lysine transport by Pseudomonas aeruginosa permease LysP. Nature Communications, 17(1), Article 37. https://doi.org/10.1038/s41467-025-66618-7

Şen, A., Karaman, E., Heegaard, C. W., Poulsen, N. A. & Buitenhuis, A. J. (2026). Predicting riboflavin (vitamin B₂) and cobalamin (vitamin B₁₂) concentrations in Danish cow milk using Fourier transform mid infrared spectra. International Dairy Journal, 179, Article 106656. https://doi.org/10.1016/j.idairyj.2026.106656

Lopez-Aguileta, L., Martín-Encinas, E., Knudsen, B. R., Tesauro, C., Schirizzi, A., Montanaro, R., D'Alessandro, R., Perrone, M. G., Stefanachi, A., Contino, M. & Alonso, C. (2026). Synthesis and biological evaluation of novel fused pyridopyrimidine derivatives as topoisomerase I inhibitors and as potential antitumor agents: promising results in lung, ovary and gastric cancer. European Journal of Medicinal Chemistry, 310, Article 118782. https://doi.org/10.1016/j.ejmech.2026.118782

De Dios Andres, P., Garg, A., Alam, R., Westensee, I. N., Kjaergaard, M. & Städler, B. (2026). Transmembrane Condensation in Albumin-Loaded Giant Vesicles Induced by an Intrinsically Disordered Protein. ChemSystemsChem, 8(3), Article e00076. https://doi.org/10.1002/syst.202500076

Vinther, S. C., Resag, A., Le, K. T. T., Zelle-Rieser, C. C., Strandt, H., Malle, M. G., Christiansen, S. H., Del Frari, B., Stigger, T., Schilling, B., Wohlfarth, J., Thiel, S., Valero, J., Stoitzner, P. & Kjems, J. (2026). Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform. Journal of Controlled Release, 392, 114741. Article 114741. https://doi.org/10.1016/j.jconrel.2026.114741

Vasilevsky, N. A., Toro, S., Matentzoglu, N., Flack, J. E., Mullen, K. R., Hegde, H., Gehrke, S., Whetzel, P. L., Shwetar, Y., Harris, N. L., Ngu, M. S., Alyea, G. L., Kane, M. S., Roncaglia, P., Sid, E., Thaxton, C. L., Wood, V., Abraham, R. S., Achatz, M. I. ... Haendel, M. A. (2026). Mondo: integrating disease terminology across communities. Genetics, 232(4). https://doi.org/10.1093/genetics/iyaf215

Lildballe, D. L., Huno, M. R., Ridder, L. O. R., Balle, C. M., Drue, S. O., Berglund, A., Dunø, M., Bak, E. N., Viuff, M. H., Rasmussen, L. S. & Gravholt, C. H. (2026). Genetic diagnosis of CYP21A2-related CAH: adaptive sampling long-read sequencing is an accurate and scalable solution. European Journal of Human Genetics, 34(4), 535-542. https://doi.org/10.1038/s41431-026-02019-8

Rattan, S. (2026). Lifespan stops at death, but when does healthspan stop? Biogerontology, 27(2), 78. Article 78. https://doi.org/10.1007/s10522-026-10424-1

Czyżewski, S., Søndergaard, S. A., Molnár, Á. P., Kerr, M. R., Kristensen, J. A., Atkinson, J., Trepel, J., Sykut, M., Radzikowski, P., Termansen, S. S., Wałach, K., Pearce, E. A., Pang, S. E. H., Zając, B., Bergman, J., Thomassen, E. S., Mungi, N., Fløjgaard, C., Ejrnæs, R. ... Svenning, J. C. (2026). Revisiting Europe's temperate forests: Palaeoecological evidence for an herbivory-driven woodland-grassland mosaic biome. Biological Conservation, 316, Article 111749. https://doi.org/10.1016/j.biocon.2026.111749

Neis, K., Civit Pitarch, L., Pedersen, K., Schachtner, M., Wengel, J., Wagner, R., Thiel, S., Kjems, J. & Valero Moreno, J. (2026). Lock, Protect, and Bind: In Vitro Selection of Locked Nucleic Acid-Modified Aptamers Using a Mutant T7 RNA Polymerase. Small Structures, 7(3), Article e202500677. https://doi.org/10.1002/sstr.202500677

Gázquez-Gutiérrez, A., Chin, P., Peris, G., Gordon, K., Marchante, P. G., Witteveldt, J., Tristán-Ramos, P., Rouvière, J. O., Knol, L. I., Ivens, A., López-Onieva, L., Estévez, A. M., Garland, W., Jensen, T. H., Heras, S. R. & Macias, S. (2026). Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8. Nucleic Acids Research, 54(5), Article gkag190. https://doi.org/10.1093/nar/gkag190

Møhlenberg, M., Jørgensen, S. E., Marije van der Sluis, R., Zillinger, T., Hinke, D. M., Hollensen, A. K., Hansen, A. L., Hausfater, P., Gorochov, G., Tubach, F., Ghosn, J., Laouenan, C., Storgaard, M., Holm, C. K., Su, H., Pérez de Diego, R., Pujol, A., Zhang, S.-Y., Zhang, Q. ... COVID Human Genetic Effort (2026). Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America, 123(12), Article e2522111123. https://doi.org/10.1073/pnas.2522111123

Mishra, A., Zubia-Aranburu, J., Zuzic, L., Saeed, K., Nielsen, J., Schio̷tt, B., Dong, M., Otzen, D. E. & Weidner, T. (2026). Structure of α-Synuclein Bound to Polystyrene Surfaces Probed by Experimental and Theoretical Sum Frequency Generation Spectroscopy. Langmuir : the ACS journal of surfaces and colloids, 42(11), 7653-7659. https://doi.org/10.1021/acs.langmuir.5c05658

Zhang, X., Hitt, P., Wanunu, M. & Kjems, J. (2026). Scalable Production of DNA-Probe-Functionalized Heteromeric MspA Nanopores for Biosensing. ACS Applied Materials and Interfaces, 18(10), 14531-14539. https://doi.org/10.1021/acsami.5c21011

Fischer, C. M., Edu, I. A., Šneideris, T., Baronaite, I., Toprakcioglu, Z., Deck, L.-T., Qian, D., Scrutton, R., Dreyer, L., Wen, J., Otzen, D. E., Wu, S., Perrett, S. & Knowles, T. P. J. (2026). Reversibility and β-sheet formation are decoupled in tau condensate aging. Proceedings of the National Academy of Sciences of the United States of America, 123(11), Article e2522993123. https://doi.org/10.1073/pnas.2522993123

Riedelbauch, S., Masser, S., Fasching, S., Lin, S. Y., Salgania, H. K., Aarup, M., Ebert, A., Jeske, M., Levine, M. T., Stelzl, U. & Andersen, P. (2026). Recurrent innovation of protein-protein interactions in the Drosophila piRNA pathway. EMBO Journal, 45(6), 1909-1932. Article 98. https://doi.org/10.1038/s44318-025-00439-8

Rodriguez, A., Formoso, E., Knudsen, B. R., Tesauro, C., Fuertes, M. & Alonso, C. (2026). Synthesis, Biological Evaluation, and Theoretical Study of Indenoquinolinylphosphine Oxide Derivatives as Topoisomerase 1 Inhibitors and Antiproliferative Agents. ChemMedChem, 21(5), Article e202500751. https://doi.org/10.1002/cmdc.202500751

Song, P., Su, J., Kristine Vraa, C. L., Gockert, M., Fjelstrup, S., Hager, H. & Kjems, J. (2026). Optimizing C14120-based LNPs for in vitro and in vivo mRNA delivery. Molecular Therapy Nucleic Acids, 37(1), Article 102866. https://doi.org/10.1016/j.omtn.2026.102866

Rast, J. E., Rosso, A. L., James, B. D., Underwood, J. F. G., Bergstedt, J., Ahlqvist, V. H., Grove, J., Fang, F., Goldstein, N. D., Vivanti, G., Levine, S. Z., Nordström, A., Schendel, D., Lyall, K., Nordström, P., Ballin, M., Stafford, J., Naj, A. C., Lee, B. K. & LEGENNDS Consortium (2026). Association of neurodevelopmental conditions with Alzheimer's disease and related dementias and Parkinson's disease. The Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 81(4), Article glaf281. https://doi.org/10.1093/gerona/glaf281

Juhl, A. D., Sprenger, R. R., Modzel, M., Halder, S., Szomek, M., Akkerman, V., Xu, Y., Heegaard, C. W., Ejsing, C. S., Covey, D. F. & Wüstner, D. (2026). Live-Cell Imaging and Lipidomics of Low-Density Lipoprotein Containing Intrinsically Fluorescent Cholesteryl Esters. Analytical Chemistry, 98(9), 7069-7083. https://doi.org/10.1021/acs.analchem.5c05064

Tedeschi, F., Quilbé, J., Fechete, L. I., Vistisen Christiansen, S. J. & Andersen, S. U. (2026). RHD6LA regulates root hair responses to both symbionts and commensals. Nature Communications. Advance online publication. https://doi.org/10.1038/s41467-026-70504-1

Zhang, H., Windhorst, A., Bornhofen, E., Tulpova, Z., Novak, P., Macas, J., Simkova, H., Nadzieja, M., Kim, J. M., Cram, D., Cao, Y., Konkin, D. J. F., Sass, O., Welna, G., Himmelbach, A., Mascher, M., Link, W., Kwon, S.-J., Yang, T.-J. ... Jayakodi, M. (2026). Allelic variation at a single locus distinguishes spring and winter faba beans. Nature Genetics, 58(3), 655-663. https://doi.org/10.1038/s41588-026-02524-y

Kaas, M., Dinesen, S. B., Ahlgreen, O., Madsen, P., Mølgaard, S., Dalby, A., Gustafsen, C., Olsen, D., Duan, J., Vilstrup, J., Lende, J., Nordestgaard, S., Zayats, T., Knappskog, P. M., Johansson, S., Neckelmann, G., Franke, B., Thirup, S., Børglum, A. ... Skeldal, S. (2026). A low frequency damaging SORCS2 variant identified in a family with ADHD compromises receptor stability and quenches activity. Molecular Psychiatry, 31(3), 1311-1324. https://doi.org/10.1038/s41380-025-03242-3

Jensen, K. T., Viana de Almeida, A. C., Rönning, S., Karlander, M., Nielsen, N. S., Thøgersen, I., Malm, M., Andersen, G. R., Enghild, J. J., Rockberg, J. & Harwood, S. L. (2026). Antagonist nanobodies prevent protease inhibition by CD109. Journal of Biological Chemistry, 302(3), Article 111187. https://doi.org/10.1016/j.jbc.2026.111187

Kjær, M. B., Jørgensen, A. G., Fjelstrup, S., Dupont, D. M., Bus, C., Oversoe, S. K., Kelsen, J., Kjems, J. & Grønbæk, H. (2026). Biomarker-directed aptamer panels for diagnosis and differentiation of neuroendocrine tumors. Journal of Neuroendocrinology, 38(3), Article e70146. https://doi.org/10.1111/jne.70146

AlZaim, I., Hassan, M. N., Schröter, M., Mannino, L., Dragicevic, K., Sjogaard, M. B., Festa, J., Dokshokova, L., Weinbrenner, S., Tardajos Ayllon, B., Hansen, B., Rasmussen, R. K., Christensen, J. N., Wagman, O., Schipper, R., Cai, M., Dheedene, W., Bohn, A. B., Farup, J. ... Kalucka, J. (2026). Defining the vascular niche of human adipose tissue across metabolic states. Nature Metabolism, 8(3), 722-740. https://doi.org/10.1038/s42255-026-01475-2

Georgaki, D., Canibe, N., van der Heide, M. E., Foldager, L., Poulsen, C. H., Mejldal, R., Velayudhan, D., Nørgaard, J. V. & Højberg, O. (2026). Impact of 1,2-α-L-fucosidase on pig enteric methane production and growth performance. Animal Microbiome, 8(1), Article 30. https://doi.org/10.1186/s42523-025-00487-9

Bergman, J., Bakarić, R. & Brčić-Kostić, K. (2026). Measures of gene indispensability reveal the parallelism between phylogeny and ontogeny. BioSystems, 261, Article 105710. https://doi.org/10.1016/j.biosystems.2026.105710

Kofod Petersen, A., Bindslev, D. A., Forgie, A., Villesen, P. & Staun Larsen, L. (2026). Objective comparison of 3D dental scans in forensic odontology identification. Forensic Imaging, 44, Article 200672. https://doi.org/10.1016/j.fri.2026.200672

Madsen, P. N., Jørgensen, P. B., Clausen, M. V. & Knudsen, C. R. (2026). Optimized purification workflow for advanced eEF1A studies: Impact of His-tagging on stability, functionality, and yield. Analytical Biochemistry, 710, Article 116017. https://doi.org/10.1016/j.ab.2025.116017

Amsinck, B. L., Benhammouche, I., Chrenková, A., Snow, A. J. D. & Pedersen, B. P. (2026). Tailored for swift recognition: A structural perspective on secondary active plant hormone transporters. Plant Journal, 125(5), Article e70762. https://doi.org/10.1111/tpj.70762

Otzen, D. E., Minero, G. A. S., Røder, H. L., Torp, A. M., Herschend, J., Nielsen, L. G., Moshynets, O., Nielsen, J., Meyer, R. L., Dueholm, M. K. D. & Burmølle, M. (2026). The house that Kocuria built: A potential role for functional amyloid in the unique cube-based structure of K. varians biofilms. Microbe (Netherlands), 10, Article 100676. https://doi.org/10.1016/j.microb.2026.100676

Rasmussen, A. M., Bouchard-Côté, A. & Pedersen, J. S. (2026). bayesReact: expression-coupled regulatory motif analysis detects microRNA activity across cancers, tissues, and at the single-cell level. Nucleic Acids Research, 54(4), Article gkag072. https://doi.org/10.1093/nar/gkag072

Kuhn, C. C., Chand, M. K., Todesca, S., Williams, K., Keidel, A., Garland, W., Jensen, T. H. & Conti, E. (2026). Direct coupling of the human nuclear exosome adaptors NEXT and PAXT with transcription termination and processing machineries. Nucleic Acids Research, 54(4), Article gkag088. https://doi.org/10.1093/nar/gkag088

Harvey, A. C., Bølcho, U., Main, B., Nykjær, A., Holm, M. M., Nissen, P., Kjærgaard, M. & Poulsen, H. (2026). Grin2b 3’UTR is necessary for synaptic plasticity and spatial learning. PNAS, 123(8), Article e2518282123. https://doi.org/10.1073/pnas.2518282123

Gordon, M., Akyol, T. Y., Amos, B., Andersen, S. U. & Williams, C. (2026). KeySDL: sparse dictionary learning for keystone microbe identification from steady-state observations using a dynamical-systems model. BioData Mining, 19(1), 18. https://doi.org/10.1186/s13040-026-00527-3

Samanta, A., Malle, M. G., Tsang, E., Omer, M., Skaanning, M. K., Youssef, S., Kjems, J. & Gothelf, K. V. (2026). Bacteriophage-Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery. Advanced Science, 13(10), Article e12844. https://doi.org/10.1002/advs.202512844

Zhang, Z.-P., Chatwin, H., Larsen, J. T., Clausen, L., Agerbo, E., Munk-Olsen, T., Bang Madsen, K., Vilhjálmsson, B. J., Petersen, L. V. & Yilmaz, Z. (2026). Medication use in severe anorexia nervosa: a Danish register-based study. BMJ Mental Health, 29(1), Article e302047. https://doi.org/10.1136/bmjment-2025-302047

Garg, A., Brasnett, C., Marrink, S. J., Koren, K. & Kjaergaard, M. (2026). Oxygen depletion in biomolecular condensates is dominated by macromolecular density. Nature Communications, 17(1), Article 2603. Advance online publication. https://doi.org/10.1038/s41467-026-69376-2

Myrup Holst, C., Esperon-Abril, I., Bryske Juhl, F., Jakobsgaard, J. E., Kristiansen, J. B., Vissing, K. & Stevnsner, T. (2026). Effect of prolonged voluntary wheel running on oxidative stress and defence mechanisms in cortex and hippocampus of healthy female rats. Experimental Physiology, 111(2), 449-463. https://doi.org/10.1113/EP092815

Otzen, D. E., Gamon, L. F., Hägglund, P., Nielsen, J., Pedersen, J. N., Nybo, T., Nowak, J. S., Amstrup, S. K., Pirhaghi, M. & Davies, M. J. (2026). Nitrated products formed on α-synuclein are preferentially incorporated into oligomers but excluded from fibrils: A mechanism for accumulation of neurotoxic species. Biochimica et Biophysica Acta - Proteins and Proteomics, 1874(2), Article 141118. https://doi.org/10.1016/j.bbapap.2025.141118

D'Alessio, A. M., Yuan, H., Soria, L. R., Hansen, S. B., Boffa, I., Arena, P., Attianese, B., O'Sullivan, M., Cullinan, N., Pang, L., van Aalten, D. M. F., Brunetti-Pierri, N. & Lynch, S. A. (2026). An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma. American Journal of Medical Genetics, Part A, 200(2), 502-510. https://doi.org/10.1002/ajmg.a.64275

Pedersen, K., Green, K., Kristoffersen, E. L., Schinkel, T., Hansen, A. G., Palarasah, Y., Rovsing, A. B., Andersen, E. S., Valero, J., Civit, L., Laursen, N. S., Troldborg, A., Degn, S. E. & Thiel, S. (2026). Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation. European Journal of Immunology, 56(2), Article e70158. https://doi.org/10.1002/eji.70158

Chrenková, A., Nashier, P., Madsen, C. L., Singh, M., Nielsen, J., Otzen, D. E., Enghild, J. J., Macek, B., Skjerning, R. B. & Brodersen, D. E. (2026). Homologous HipA-like kinases are controlled by internal translational initiation and genetic organisation. FEBS Letters, 600(3), 356-369. https://doi.org/10.1002/1873-3468.70234

Svraka, L., Andersen, A. S., Touborg, T., Emmanuel, T., GK, U., Kadarmideen, H., Bertelsen, T., Vestergaard, C. & Johansen, C. (2026). IL-17 Cytokines Induce IκBζ in Dermal Fibroblasts to Promote Pro-Inflammatory Gene Expression in Psoriasis. International Journal of Molecular Sciences , 27(3), Article 1297. https://doi.org/10.3390/ijms27031297

Demontis, D., Duan, J., Hsu, Y.-H. H., Pintacuda, G., Grove, J., Nielsen, T. T., Thirstrup, J., Martorana, M., Botts, T., Satterstrom, F. K., Bybjerg-Grauholm, J., Tsai, J. H. Y., Glerup, S., Hoogman, M., Buitelaar, J., Klein, M., Ziegler, G. C., Jacob, C., Grimm, O. ... Børglum, A. D. (2026). Rare genetic variants confer a high risk of ADHD and implicate neuronal biology. Nature, 649(8098), 909-917. https://doi.org/10.1038/s41586-025-09702-8

Wang, X., Aninta, S. G., Garcia-Erill, G., Li, Z., Khan, A., Liu, X., Bertola, L. D., Dharmayanthi, A. B., Yulianto, Yonathan, Rossi, C., Cauble-Sims, R., Rosen, B. D., Hagen, D. E., Heaton, M. P., Smith, T. P. L., Lenstra, J. A., Martins, N. F. G., Sinding, M. H. S. ... Heller, R. (2026). Population structure and domestication history of the Javan banteng. Current Biology, 36(2), 458-473.e8. https://doi.org/10.1016/j.cub.2025.11.076