Peer-reviewed articles

Publications from the department

Journal covers made by researchers from our department

Villa-Rodriguez, E., Lugo-Enríquez, C., Ferguson, S., Parra-Cota, F. I., Cira-Chávez, L. A. & de los Santos-Villalobos, S. (2022). Trichoderma harzianum sensu lato TSM39: A wheat microbiome fungus that mitigates spot blotch disease of wheat (Triticum turgidum L. subsp. durum) caused by Bipolaris sorokiniana. Biological Control, 175, [105055]. https://doi.org/10.1016/j.biocontrol.2022.105055

Quilbé, J., Montiel, J., Arrighi, J. F. & Stougaard, J. (2022). Molecular Mechanisms of Intercellular Rhizobial Infection: Novel Findings of an Ancient Process. Frontiers in Plant Science, 13, [922982]. https://doi.org/10.3389/fpls.2022.922982

Cortleven, A., Roeber, V. M., Frank, M., Bertels, J., Lortzing, V., Beemster, G. T. S. & Schmülling, T. (2022). Photoperiod Stress in Arabidopsis thaliana Induces a Transcriptional Response Resembling That of Pathogen Infection. Frontiers in Plant Science, 13, [838284]. https://doi.org/10.3389/fpls.2022.838284

Sønderby, T. V., Najarzadeh, Z. & Otzen, D. E. (2022). Functional Bacterial Amyloids: Understanding Fibrillation, Regulating Biofilm Fibril Formation and Organizing Surface Assemblies. Molecules, 27(13), [4080]. https://doi.org/10.3390/molecules27134080

Kristensen, M. F., Sorensen, E. S., Del Rey, Y. C. & Schlafer, S. (2022). Prevention of Initial Bacterial Attachment by Osteopontin and Other Bioactive Milk Proteins. Biomedicines, 10(8), [1922]. https://doi.org/10.3390/biomedicines10081922

Stevnsner, T. & Sanchez-Roman, I. (2022). Molecular markers associated with cognitive impairment in centenarians. Aging, 14(10), 4191-4192. https://doi.org/10.18632/aging.204094

Fjelstrup, S., Dupont, D. M., Bus, C., Enghild, J. J., Jensen, J. B., Birkenkamp-Demtröder, K., Dyrskjøt, L. & Kjems, J. (2022). Differential RNA aptamer affinity profiling on plasma as a potential diagnostic tool for bladder cancer. NAR cancer, 4(3), [zcac025]. https://doi.org/10.1093/narcan/zcac025

Pedersen, H., Jensen, R. K., Hansen, A. G., Petersen, S. V., Thiel, S., Laursen, N. S. & Andersen, G. R. (2022). Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity. Frontiers in Immunology, 13, 872536. https://doi.org/10.3389/fimmu.2022.872536

Mitchell, C. W., Czajewski, I. & van Aalten, D. M. F. (2022). Bioinformatic prediction of putative conveyers of O-GlcNAc Transferase intellectual disability. The Journal of Biological Chemistry, 298(9), [102276]. https://doi.org/10.1016/j.jbc.2022.102276

Dijkman, R., Verma, A. K., Selvaraj, M., Ghimire, R., Gad, H. H., Hartmann, R., More, S., Perlman, S., Thiel, V. & Channappanavar, R. (2022). Effective Interferon Lambda Treatment Regimen To Control Lethal MERS-CoV Infection in Mice. Journal of Virology, 96(11), [e00364-22]. https://doi.org/10.1128/jvi.00364-22

Gultom, M., Kratzel, A., Portmann, J., Stalder, H., Chanfon Bätzner, A., Gantenbein, H., Gurtner, C., Ebert, N., Gad, H. H., Hartmann, R., Posthaus, H., Zanolari, P., Pfaender, S., Thiel, V. & Dijkman, R. (2022). Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus. Scientific Reports, 12(1), [10340]. https://doi.org/10.1038/s41598-022-13777-y

Meyer, F., Fritz, A., Deng, Z. L., Koslicki, D., Lesker, T. R., Gurevich, A., Robertson, G., Alser, M., Antipov, D., Beghini, F., Bertrand, D., Brito, J. J., Brown, C. T., Buchmann, J., Buluç, A., Chen, B., Chikhi, R., Clausen, P. T. L. C., Cristian, A. ... McHardy, A. C. (2022). Critical Assessment of Metagenome Interpretation: the second round of challenges. Nature Methods, 19(4), 429-440. https://doi.org/10.1038/s41592-022-01431-4

Sahin, C., Østerlund, E. C., Österlund, N., Costeira-Paulo, J., Pedersen, J. N., Christiansen, G., Nielsen, J., Grønnemose, A. L., Amstrup, S. K., Tiwari, M. K., Rao, R. S. P., Bjerrum, M. J., Ilag, L. L., Davies, M. J., Marklund, E. G., Pedersen, J. S., Landreh, M., Møller, I. M., Jørgensen, T. J. D. & Otzen, D. E. (2022). Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization. Journal of the American Chemical Society, 144(27), 11949-11954. https://doi.org/10.1021/jacs.2c03607

Fruergaard, M. U., Dach, I., Andersen, J. L., Ozol, M., Shasavar, A., Quistgaard, E. M. H., Poulsen, H., Fedosova, N. & Nissen, P. (2022). The Na,K-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state. Journal of Biological Chemistry, 298(9), [102317]. https://doi.org/10.1016/j.jbc.2022.102317

Gerlach, P., Garland, W., Lingaraju, M., Salerno-Kochan, A., Bonneau, F., Basquin, J., Jensen, T. H. & Conti, E. (2022). Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Molecular Cell, 82(13), 2505-2518.e7. https://doi.org/10.1016/j.molcel.2022.04.011

Jensen, R. K., Pedersen, H., Lorentzen, J., Laursen, N. S., Vorup-Jensen, T. & Andersen, G. R. (2022). Structural insights into the function-modulating effects of nanobody binding to the integrin receptor α_Mβ₂. Journal of Biological Chemistry, 298(8), [102168]. https://doi.org/10.1016/j.jbc.2022.102168

Bisiak, F., Chrenková, A., Zhang, S. D., Pedersen, J. N., Otzen, D. E., Zhang, Y. E. & Brodersen, D. E. (2022). Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response. Journal of Biological Chemistry, 298(7), [102142]. https://doi.org/10.1016/j.jbc.2022.102142

Jiang, M., Dai, S., Zheng, Y. C., Li, R. Q., Tan, Y. Y., Pan, G., Møller, I. M., Song, S. Y., Huang, J. Z. & Shu, Q. Y. (2022). An alanine to valine mutation of glutamyl-tRNA reductase enhances 5-aminolevulinic acid synthesis in rice. Theoretical and Applied Genetics, 135(8), 2817-2831. https://doi.org/10.1007/s00122-022-04151-7

Pupak, A., Singh, A., Sancho-Balsells, A., Alcalá-Vida, R., Espina, M., Giralt, A., Martí, E., Ørom, U. A. V., Ginés, S. & Brito, V. (2022). Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington’s disease mice. Cellular and Molecular Life Sciences, 79(8), [416]. https://doi.org/10.1007/s00018-022-04444-6

Alsarraf, H. M. A. B., Ung, K. L., Johansen, M. D., Dimon, J., Olieric, V., Kremer, L. & Blaise, M. (2022). Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N-acetyltransferase. FEBS Letters, 596(12), 1516-1532. https://doi.org/10.1002/1873-3468.14360

Cai, Z., Wu, X., Thomsen, B. & Sahana, G. (2022). Fine-mapping young-stock survival QTL on chromosome 6 in Nordic Red Dairy Cattle. In WCGALP 2022 Programme book Wageningen Academic Publishers.

Schröder, S. K., Schüler, H. M., Petersen, K. V., Tesauro, C., Knudsen, B. R., Pedersen, F. S., Krus, F., Buhl, E. M., Roeb, E., Roderfeld, M., Borojevic, R., Almeida, J. L. & Weiskirchen, R. (2022). Genetic and Molecular Characterization of the Immortalized Murine Hepatic Stellate Cell Line GRX. Cells, 11(9), [1504]. https://doi.org/10.3390/cells11091504

Fukai, E., Yoshikawa, M., Shah, N., Sandal, N., Miyao, A., Ono, S., Hirakawa, H., Akyol, T. Y., Umehara, Y., Nonomura, K-I., Stougaard, J., Hirochika, H., Hayashi, M., Sato, S., Andersen, S. U. & Okazaki, K. (2022). Widespread and transgenerational retrotransposon activation in inter- and intra-species recombinant inbred populations of Lotus japonicus. The Plant Journal, 111(5), 1397-1410. https://doi.org/10.1111/tpj.15896

Møhlenberg, M., Eriksen, P. L., Laursen, T. L., Nielsen, M. B., Hamilton-Dutoit, S. J., Grønbæk, H., Hartmann, R. & Thomsen, K. L. (2022). The presence of interferon affects the progression of non-alcoholic fatty liver disease. Genes and Immunity, 23(5), 157–165. https://doi.org/10.1038/s41435-022-00176-6

Aminzadeh, A., Larsen, C. E., Boesen, T. & Jørgensen, R. (2022). High-resolution structure of native toxin A from Clostridioides difficile. EMBO Reports, 23(1), [e53597]. https://doi.org/10.15252/embr.202153597

Jepsen, M. R., Østergaard, J. A., Conover, C. A., Wogensen, L., Birn, H., Krag, S. P., Fenton, R. A. & Oxvig, C. (2022). Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy. Metabolism: Clinical and Experimental, 132, [155218]. https://doi.org/10.1016/j.metabol.2022.155218

Rafiq, M., Ernst, H. A., Aduri, N. G., Prabhala, B. K., Tufail, S., Rahman, M., Bloch, M. B., Mirza, N., Taylor, N. M. I., Boesen, T., Gajhede, M. & Mirza, O. (2022). Expression, purification and characterization of human proton-coupled oligopeptide transporter 1 hPEPT1. Protein Expression and Purification, 190, [105990]. https://doi.org/10.1016/j.pep.2021.105990

Jakobsen, A. K., Yuusufi, S., Madsen, L. B., Meldgaard, P., Knudsen, B. R. & Stougaard, M. (2022). TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data. Lung Cancer, 164, 23-32. https://doi.org/10.1016/j.lungcan.2021.12.010

Fuertes, M., Selas, A., Trejo, A., Knudsen, B. R., Palacios, F. & Alonso, C. (2022). Synthesis of hybrid phosphorated indenoquinolines and biological evaluation as topoisomerase I inhibitors and antiproliferative agents. Bioorganic and Medicinal Chemistry Letters, 57, [128517]. https://doi.org/10.1016/j.bmcl.2021.128517

Dyla, M., González Foutel, N. S., Otzen, D. E. & Kjaergaard, M. (2022). The optimal docking strength for reversibly tethered kinases. Proceedings of the National Academy of Sciences of the United States of America, 119(25), [e2203098119]. https://doi.org/10.1073/pnas.2203098119

Tapia-Galisteo, A., Sánchez Rodríguez, Í., Aguilar-Sopeña, O., Harwood, S. L., Narbona, J., Ferreras Gutierrez, M., Navarro, R., Martín-García, L., Corbacho, C., Compte, M., Lacadena, J., Blanco, F. J., Chames, P., Roda-Navarro, P., Álvarez-Vallina, L. & Sanz, L. (2022). Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer. OncoImmunology, 11(1), [2034355]. https://doi.org/10.1080/2162402X.2022.2034355

Hansen, S. B. & Andersen, K. R. (2022). Introducing Cysteines into Nanobodies for Site-Specific Labeling. In G. Hussack & K. A. Henry (Eds.), Single-Domain Antibodies: Methods and Protocols (pp. 327-343). Humana Press. Methods in Molecular Biology Vol. 2446 https://doi.org/10.1007/978-1-0716-2075-5_16

Nielsen, N. S., Zarantonello, A., Harwood, S. L., Jensen, K. T., Kjøge, K., Thøgersen, I. B., Schauser, L., Karlsen, J. L., Andersen, G. R. & Enghild, J. J. (2022). Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nature Communications, 13(1), [3033]. https://doi.org/10.1038/s41467-022-30758-x

Kjaergaard, M. (2022). Estimation of Effective Concentrations Enforced by Complex Linker Architectures from Conformational Ensembles. Biochemistry, 61(3), 171-182. https://doi.org/10.1021/acs.biochem.1c00737

Märcher, A., Kumar, V., Andersen, V. L., El-Chami, K., Nguyen, T. J. D., Skaanning, M. K., Rudnik-Jansen, I., Nielsen, J. S., Howard, K. A., Kjems, J. & Gothelf, K. V. (2022). Functionalized Acyclic (l)-Threoninol Nucleic Acid Four-Way Junction with High Stability In Vitro and In Vivo. Angewandte Chemie - International Edition, 61(24), [202115275]. https://doi.org/10.1002/anie.202115275

Pothoulakis, G., Nguyen, M. T. A. & Andersen, E. S. (2022). Utilizing RNA origami scaffolds in Saccharomyces cerevisiae for dCas9-mediated transcriptional control. Nucleic Acids Research, 50(12), 7176-7187. https://doi.org/10.1093/nar/gkac470

Møhlenberg, M., O’Brien, T. R. & Hartmann, R. (2022). The role of IFNL4 in liver inflammation and progression of fibrosis. Genes and Immunity, 23(3-4), 111-117. https://doi.org/10.1038/s41435-022-00173-9

Alam, P., Holst, M. R., Lauritsen, L., Nielsen, J., Nielsen, S. S. E., Jensen, P. H., Brewer, J. R., Otzen, D. E. & Nielsen, M. S. (2022). Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers. Fluids and Barriers of the CNS, 19(1), [37]. https://doi.org/10.1186/s12987-022-00334-y

Gómez-Cuadrado, L., Bullock, E., Mabruk, Z., Zhao, H., Souleimanova, M., Noer, P. R., Turnbull, A. K., Oxvig, C., Bertos, N., Byron, A., Dixon, J. M., Park, M., Haider, S., Natrajan, R., Sims, A. H. & Brunton, V. G. (2022). Characterisation of the Stromal Microenvironment in Lobular Breast Cancer. Cancers, 14(4), [904]. https://doi.org/10.3390/cancers14040904

Selnihhin, D., Mortensen, K. I., Larsen, J. B., Simonsen, J. B. & Pedersen, F. S. (2022). DNA Origami Calibrators for Counting Fluorophores on Single Particles by Flow Cytometry. Small Methods, 6(3), [2101364]. https://doi.org/10.1002/smtd.202101364

Rouvière, J. O., Lykke-Andersen, S. & Jensen, T. H. (2022). Control of non-productive RNA polymerase II transcription via its early termination in metazoans. Biochemical Society Transactions, 50(1), 283-295. https://doi.org/10.1042/BST20201140

Dieudonné, T., Herrera, S. A., Laursen, M. J., Lejeune, M., Stock, C., Slimani, K., Jaxel, C., Lyons, J. A., Montigny, C., Pomorski, T. G., Nissen, P. & Lenoir, G. (2022). Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders. eLife, 11, [e75272]. https://doi.org/10.7554/eLife.75272

Gomes-Duarte, A., Venø, M. T., de Wit, M., Senthilkumar, K., Broekhoven, M. H., van den Herik, J., Heeres, F. R., van Rossum, D., Rybiczka-Tesulov, M., Legnini, I., van Rijen, P. C., van Eijsden, P., Gosselaar, P. H., Rajewsky, N., Kjems, J., Vangoor, V. R. & Pasterkamp, R. J. (2022). Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology. Frontiers in Molecular Neuroscience, 15, [832133]. https://doi.org/10.3389/fnmol.2022.832133

Winkler, M. B. L., Nel, L., Frain, K. M., Dedic, E., Olesen, E. & Pedersen, B. P. (2022). Sterol uptake by the NPC system in eukaryotes: a Saccharomyces cerevisiae perspective. FEBS Letters, 596(2), 160-179. https://doi.org/10.1002/1873-3468.14253

Ommen, P., Hansen, L., Hansen, B. K., Vu-Quang, H., Kjems, J. & Meyer, R. L. (2022). Aptamer-Targeted Drug Delivery for Staphylococcus aureus Biofilm. Frontiers in cellular and infection microbiology, 12, [814340]. https://doi.org/10.3389/fcimb.2022.814340

Garland, W., Müller, I., Wu, M., Schmid, M., Imamura, K., Rib, L., Sandelin, A., Helin, K. & Jensen, T. H. (2022). Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression. Molecular Cell, 82(9), 1691-1707.e8. https://doi.org/10.1016/j.molcel.2022.03.004

Gupta, K. J., Kaladhar, V. C., Fitzpatrick, T. B., Fernie, A. R., Møller, I. M. & Loake, G. J. (2022). Nitric oxide regulation of plant metabolism. Molecular Plant, 15(2), 228-242. https://doi.org/10.1016/j.molp.2021.12.012

Gockert, M., Schmid, M., Jakobsen, L., Jens, M., Andersen, J. S. & Jensen, T. H. (2022). Rapid factor depletion highlights intricacies of nucleoplasmic RNA degradation. Nucleic Acids Research, 50(3), 1583-1600. https://doi.org/10.1093/nar/gkac001

Mogensen, E. H., Poulsen, E. T., Thøgersen, I. B., Yamamoto, K., Brüel, A. & Enghild, J. J. (2022). The low-density lipoprotein receptor-related protein 1 (LRP1) interactome in the human cornea. Experimental Eye Research, 219, [109081]. https://doi.org/10.1016/j.exer.2022.109081

Ung, K. L., Alsarraf, H., Kremer, L. & Blaise, M. (2022). Corrigendum to “MmpL3, the trehalose monomycolate transporter, is stable in solution in several detergents and can be reconstituted into peptidiscs” [Protein Expr. Purif. 191 (March 2022) 106014]. Protein Expression and Purification, 195-196, [106088]. https://doi.org/10.1016/j.pep.2022.106088

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Revised 27.09.2022

Lisbeth Heilesen

Department of Molecular Biology and Genetics

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