During the course of his PhD studies, Emil Dedic studied the mechanisms involved in processing stable RNA in the yeast Saccharomyces cerevisiae. Proper processing generates stable RNA, responsible for the modulation and guidance of a wide range of essential processes in the cell.

The RNA nuclease Rrp6p is a key factor in RNA processing. Emil Dedic investigated its role in processing RNA, together with its putative cofactor Rrp47p. By using a biochemical approach to study the yeast genes, he found how the cofactor Rrp47p modulates the activity of the processing protein Rrp6p. A combined structural biology and biophysics approach provides a better understanding of the structural interactions and functions of these proteins.

The PhD degree was completed at the Section for Structural Biology, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.

Time: Monday 28 April 2014 at 14.15
Place: Lecture Theatre, iNANO, Aarhus University, Gustav Wieds Vej, Aarhus C
Title of dissertation: Structural basis for maturation of stable RNA in yeast nucleus
Contact information: Emil Dedic, emd@mb.au.dk
Members of the assessment committee:
Group Leader Andrew Carter, MRC Laboratory of Molecular Biology, Cambridge, UK
Associate Professor Bente Vestergaard, Department of Drug Design and Pharmacology, Biostructural Research, University of Copenhagen
Associate Professor Charlotte Rohde Knudsen (chair), Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Associate Professor Ditlev Egeskov Brodersen, Department of Molecular Biology and Genetics, Aarhus University
Language: The dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.