Jamal Momeni: Detailed analysis of the relationship between DNA methylation and gene expression

Methylation of DNA cytosine residues is an important epigenetic modification that plays important roles in differentiation and development, as well as in several diseases. Moreover, methylation has been observed to have important implications in modulating gene expression. Recent advances in genomic technologies using next-generation sequencing make it possible to carry out detailed analysis of methylation and transcriptomics data using BS-seq and RNA-seq technologies.

During his PhD studies, Jamal Momeni researched the relationship between DNA methylation and gene expression. In summary, he used high-throughput technologies to study global methylation variation and transcription profiles at genome level. High-resolution DNA methylation maps for two porcine tissues – liver and brain – and the integrated analysis of transcriptome and methylome data have expanded the understanding of DNA methylation patterns at different genomic regions, as well as revealing new features of the complicated association between DNA methylation and gene expression.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.

Time: Thursday 12 September 2013 at 13.00
Place: Lecture Theatre, AU Foulum, Blichers Allé 30, 8830 Tjele
Title of dissertation: Detailed Analysis of the relationship between DNA Methylation and Gene Expression
Contact information: Jamal Momeni, jamal.momeni@agrsci.dk
Members of the assessment committee:
Associate Professor Yungui Yang, Beijing Institute of Genomics, Chinese Academy of Sciences
Associate Professor Kåre Lehmann Nielsen, Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University
Associate Professor Bernt Guldbrandtsen (chair), Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Research Professor Christian Bendixen, Department of Molecular Biology and Genetics, Aarhus University
Co-supervisor:
Associate Professor Frank Panitz, Department of Molecular Biology and Genetics, Aarhus University
Language: The dissertation will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.