Wednesday 6 May @ 13:15 – 14:00
Followed by PhD-session at 14:30-15:00
(Coffee and cake will be served between lecture and PhD-session)
1871-120 (Nucleus)
Hosted by: Taro Kitazawa

Measuring, modeling, and reprogramming tissue organization

Tissues are not simply collections of cell types, but organized multicellular communities whose structure across space and time helps determine function in development, homeostasis, aging, and disease. In this lecture, I will describe my lab’s efforts to define the principles by which molecularly distinct cells assemble into tissue architectures, communicate with one another, and change state in response to both local environment and cellular history. To address these questions, we develop and apply genomic technologies that preserve spatial organization, record aspects of cellular history, and connect molecular state to multicellular function. Using these approaches, we have mapped tissue architecture at single-cell resolution, identified how spatial context shapes cell state and cell-cell interactions, and begun to uncover signaling dependencies within diseased tissues. I will conclude by discussing our broader goal of moving from descriptive tissue maps toward predictive models and experimental strategies to measure, understand, and ultimately engineer tissue organization in vivo.