During his PhD studies, Md Mesbah Uddin investigated large-scale genomics data on Nordic Holstein, Danish Jersey, Nordic Red and French Normande dairy cattle to identify fertility associated causal variants. His analyses involved both small and large sequence variants. His research outputs included a catalog of large chromosomal deletions with imputed genotypes on thousands of animals from the three Nordic dairy breeds, and the identification of a candidate lethal mutation in Normande cattle.

Md Mesbah Uddin also performed association mapping and genomic prediction for female fertility using imputed sequence variants. His studies highlighted the importance of large deletions, beside small sequence variants, as predictor for female fertility in dairy cattle.

The new research findings can be used to make mating-decision (to avoid at-risk mating) and to improve accuracy of genomic estimated breeding values in dairy cattle.

The PhD degree was completed at Center for Quantitative Genetics and Genomics (QGG), Department of Molecular Biology and Genetics, Aarhus University, DK, and Animal Genetics and Integrative Biology, AgroParisTech/INRA, France.  

This résumé was prepared by the PhD student.

Time: Tuesday 17 September 2019 at 10.00
Place: Aarhus University, 8814-3050 M2, Blichers Allé 20, Foulum, 8830 Tjele, DK
Title of PhD thesis: Identification of causal factors for recessive lethals in dairy cattle with special focus on large chromosomal deletions
Contact information: Md Mesbah Uddin, e-mail: mesbah@mbg.au.dk, mobile number: +45 91612457
Members of the assessment committee:
Professor Göran Andersson, Department of Livestock Genetics, Swedish University of Agricultural Sciences, Sweden
Professor MSO Claus Bøttcher Jørgensen, Department of Veterinary and Animal Sciences, University of Copenhagen, DK
Professor Just Jensen (chair), Department of Molecular Biology and Genetics, Aarhus University, DK
Main supervisor:
Senior Researcher Dr. Goutam Sahana, Department of Molecular Biology and Genetics, Aarhus University, DK
Senior Researcher Dr. Didier Boichard, Animal Genetics and Integrative Biology, AgroParisTech/INRA, France
Co-supervisor:
Professor Mogens Sandø Lund, Department of Molecular Biology and Genetics, Aarhus University, DK
Associate Professor Bernt Guldbrandtsen, Department of Molecular Biology and Genetics, Aarhus University, DK
Dr. Aurélien Capitan, Animal Genetics and Integrative Biology, AgroParisTech/INRA, France; Allice, France
Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, 8000 Aarhus C.