Michal Lubas: Distinct RNA degradation pathways in humans
PhD defence, Monday 28 January 2013. Michal Lubas.
RNA synthesis and degradation are key steps regulating gene expression in all living organisms. During the course of his PhD studies, Michal Lubas centered his research around nuclear and cytoplasmic RNA turnover of both noncoding and coding RNAs in human cells. His proteomic studies revealed the interaction network of the main 3’-5’ RNA degradation machinery – the RNA exosome complex. One of the key findings was the identification and characterization of the Nuclear Exosome Targeting (NEXT) complex, important for nuclear functions of the exosome.
Michal also studied the role of the cytoplasmic 3’-5’ exoribonuclease hDIS3L2. Using both in vivo and in vitro, low- and high-throughput techniques, he characterized the nuclease and disclosed an impact of hDIS3L2 on cytoplasmic mRNA metabolism.
The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.
Time: Monday 28 January 2013 at 15.00
Place: Aud. G2, Department of Mathematics, Aarhus University
Title of dissertation: 3'-5' RNA degradation pathways in human cells
Contact information: Michal Lubas, e-mail: mic@mb.au.dk, tel.: +45 52802302
Members of the assessment committee:
Professor Bertrand Séraphin, Research Director at the CNRS, IGBMC, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France
Professor Anders Henrik Lund, BRIC, Københavns Universitet
Associate Professor Ernst-Martin Füchtbauer (chair), Department of Molecular Biology and Genetics, Aarhus University
Main supervisor:
Professor Torben Heick Jensen, Department of Molecular Biology and Genetics, Aarhus University
Co-supervisor:
Associate Professor Andrzej Dziembowski, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
Language: The PhD dissertation will be defended in English.
The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, room 112, 8000 Aarhus C.